Prevalence of Visual Symptoms Among Patients With Newly Diagnosed Cytomegalovirus Retinitis

Wei, Lisa L.; Park, Susanna Soon Chun; Skiest, Daniel J.

doi:10.1097/00006982-200206000-00004

Cited by 28 publications

(18 citation statements)

References 17 publications

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“…As in other studies, most of these patients have longstanding AIDS, had received HAART and are intolerant or non responsive to this therapy (4)(5)(6) . Visual symptoms were frequent at the time of diagnosis and blurring was the most common presenting symptom, as previously described (22) . Patients with more severe disease, including HAART-failure and extraocular CMV disease, had a worse prognosis, evolving with visual loss and CMV retinitis relapses.…”

Section: Discussionsupporting

confidence: 67%

Clinical features and outcomes of AIDS-related cytomegalovirus retinitis in the era of highly active antiretroviral therapy

Arantes¹,

Garcia²,

Saraceno³

et al. 2010

Arq. Bras. Oftalmol.

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Clinical features and outcomes of AIDS-related cytomegalovirus retinitis in the era of highly active antiretroviral therapy Keywords: Cytomegalovirus; Retinitis; Acquired immunodeficiency syndrome; Antiretroviral therapy, highly active; AIDS-related opportunistic infections; Uveitis, posterior; Eye infections/etiology; HIV infections Purpose: To describe the features and outcomes of patients with AIDS-related cytomegalovirus retinitis after highly active antiretroviral therapy availability. Methods: Retrospective chart review of 30 consecutive patients (44 eyes) with AIDS and newly diagnosed, active AIDS-related cytomegalovirus retinitis, examined from January 2005 to December 2007. Results: The mean age was 34.8 years, 18 patients (60.0%) were male and median duration of AIDS was 90 months. Nineteen patients (63.3%) had evidence of highly active antiretroviral therapy failure and median CD4+ lymphocyte count was 12.5 cells/µl. Visual acuity at presentation was 20/40 or better in 27 eyes (61.4%). Retinitis involved Zone 1 in 13 eyes (39.5%). Despite specific anti-AIDSrelated cytomegalovirus therapy, 16 eyes (36.4%) presented relapse of retinitis and 10 eyes (22.7%) lost at least three lines of vision. When compared to highly active antiretroviral therapy responsive patients, eyes of highly active antiretroviral therapy failure patients were more likely to develop relapse of retinitis (p=0.03) and loss of at least three lines of vision (p=0.03). Conclusion: The patients in this series are essentially young men with longstanding AIDS, non-responsive to highly active antiretroviral therapy and with a similar immunological profile as noted before highly active antiretroviral therapy era. These findings have implications for the management of the disease and confirm the magnitude of rational periodic screening after diagnosis of AIDS. ABSTRACT INTRODUCTION

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Section: Discussionsupporting

confidence: 67%

Clinical features and outcomes of AIDS-related cytomegalovirus retinitis in the era of highly active antiretroviral therapy

Arantes¹,

Garcia²,

Saraceno³

et al. 2010

Arq. Bras. Oftalmol.

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“…In a HCMV retinitis study by Wei et al [47] 12% of patients had an extraocular HCMV disease, while other studies showed only 10% of patients to have extraocular HCMV disease before the diagnosis of retinitis [43]. These data may suggest that the onset of HCMV retinitis in this population results from virus reactivation rather than from a fresh retinal infection by circulating virus.…”

Section: Discussionmentioning

confidence: 89%

“…In a recent study of HIV-infected patients with newly diagnosed HCMV retinitis the prevalence and type of visual symptoms was studied [47]. The mean age of 138 assessed patients was 36 years (range 22-55 years).…”

Section: Discussionmentioning

confidence: 99%

The human eye (retina): a site of persistent HCMV infection?

Vogel

Fleckenstein

Wagner

et al. 2005

Graefe's Arch Clin Exp Ophthalmol

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“…Nevertheless, in a recent retrospective analysis of HIV-positive patients, a higher percentage of those with documented CMV retinitis had visual symptoms at the time of diagnosis compared with matched control HIV-positive patients without CMV retinitis (88 Vs. 53%, respectively) (Wei et al, 2002). The most common presenting symptoms are decreased visual acuity (67), floaters (49), photopsia (16), eye pain (7) and scotomas (3%) (Hodge et al, 2004).…”

Section: Ocular Manifestationsmentioning

confidence: 99%

Herpetic Viral Retinitis

Noma¹

2013

American Journal of Virology

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Human Herpes Virus (HHV) is a DNA virus and is the most important viral pathogen causing intraocular inflammation. HHV is classified into types 1-8. Among these types, HHV-1, HHV-2, HHV-3 Varicella Zoster Virus (VZV) and HHV-5 Cytomegalovirus (CMV) are known to cause herpetic viral retinitis, including acute retinal necrosis and CMV retinitis. Herpes viral retinitis can be diagnosed from characteristic ocular findings and viral identification by PCR of the aqueous humor. Recently, therapy has become more effective than in the past. Herpes viral retinitis gradually progresses if appropriate treatment is not provided with regard to the patient's immune status. Further advances in diagnostic methods and treatment are required in the future.

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Prevalence of Visual Symptoms Among Patients With Newly Diagnosed Cytomegalovirus Retinitis

Abstract: Most HIV-infected patients with newly diagnosed CMV retinitis had visual symptoms at presentation regardless of the zone of retinal involvement. The incidence of visual symptoms correlated with the degree of retinal involvement.

Cited by 28 publications

References 17 publications

Clinical features and outcomes of AIDS-related cytomegalovirus retinitis in the era of highly active antiretroviral therapy

Clinical features and outcomes of AIDS-related cytomegalovirus retinitis in the era of highly active antiretroviral therapy

The human eye (retina): a site of persistent HCMV infection?

Herpetic Viral Retinitis

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