Prevalence of vitamin B12 deficiency in Indian type 2 diabetes subjects on metformin therapy

Kumar, Raj; Shetty, Surekha B.; Lalitha, R.

doi:10.17511/ijmrr.2017.i09.03

Cited by 5 publications

(8 citation statements)

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“…In the present study, we also observed the lack of association between the vitamin B 12 level and the duration of therapy with metformin. This result is consistent with those reported in other studies [4,19]. In contrast, some authors have shown that the reduction of serum vitamin B 12 concentration is associated with duration of metformin therapy and is induced in a dose-dependent manner [16,18,20,38] The complex interaction between the oxidative stress and inflammation in T2DM patients contribute to the alteration of erythrocyte homeostasis and cause an increase in RDW values [1,23,26].…”

Section: Resultssupporting

confidence: 90%

The Frequency of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus Treated With Metformin for at Least Five Years

Craciun¹

2021

FARMACIA

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Section: Resultssupporting

confidence: 90%

The Frequency of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus Treated With Metformin for at Least Five Years

Craciun¹

2021

FARMACIA

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“…The prevalence of vitamin B12 deficiency as reported Anil Kumar R.et al was 27.33% in T2DM subjects on metformin therapy and the percentage of deficiency increased with increase in dosage of metformin with no correlation to duration of metformin therapy. 6 Our study showed a clear relationship between the dosage or length of metformin use and vitamin B12 deficiency in patients with type 2 diabetes though comparing the obtained prevalence with the results of previous studies is not straightforward and should consider several factors. The prevalence rates of vitamin B12 deficiency (<191 ng/L) were 27% and 12% in Europeans and Indians respectively, and higher in metformin treated type 2 diabetes patients.…”

Section: Discussionmentioning

confidence: 57%

Haematological Parameters and Vitamin B12 Levels in Type Ii Diabetic Patients on Metformin- A Prospective Case Control Study

Koduri¹,

Nori²,

K³

et al. 2018

jebmh

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BACKGROUND Metformin is the cornerstone medication in the management of type 2 diabetes mellitus (T2DM) with estimates that it is routinely prescribed to 120 million type 2 diabetes patients around the world. Preceding studies say long term use of metformin in T2DM lowers vitamin-B12 levels and its clinical manifestations can be misdiagnosed as diabetic peripheral neuropathy. The aim of this study is to correlate haematological parameters with estimated serum Vit. B12 levels in T2DM patients on long term metformin in patient subjects and healthy volunteers. MATERIALS AND METHODS A total of 34 T2DM patients (cases) and 34 healthy volunteers (controls) were enrolled in the study from the outpatient department and in-patient wards of RVM Hospital, for over a period of 6 months. Serum vitamin-B12, HbA1c and haematological parameters were measured. RESULTS The clinical characteristics and serum vitamin-B12 levels of the study population were compared using chi-square cross tabulation. Vitamin-B12 deficiency was higher in T2DM patients taking daily dose of metformin >1000 mg/day. Hematological parameters estimation and peripheral smear study was done in all cases to identify macrocytic anaemia and hyper segmented polymorphs.

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“…The average duration of diabetes mellitus and metformin therapy were reported as 10.92±8.95 years and 8.66±7.24 years respectively. The average duration of Diabetes mellitus and metformin therapy in the study done by 12 Kumar A at al. were reported as 9.93±6.82 years and 9.60±6.15 years respectively and the average age was reported as 58.89±13.12 years.…”

Section: Discussionmentioning

confidence: 99%

“…The mean value of vitamin B12 was less with increased duration of diabetes. 12 Kumar A et al , it was found that 29.3% of the 215 patients had vitamin B12 deficiencies. A statistically significant difference (p <0.05) was observed in the metformin treatment of about 55 patients with vitamin B12 deficiency over a period of more than 4 years.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Vitamin B12 Amongdiabetic Patients Under Treatment With Metformin in a Tertiary Care Centre

Premkumar,

Annie Philip,

Chettiyar

2024

Global Journal for Research Analysis

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Background: Type 2 diabetes mellitus (DM) is a widespread metabolic health disease. The oral hypoglycemic drug metformin is prescribed to type 2 diabetic patients worldwide as a first line treatment along with lifestyle changes.The risk of vitamin B12 deficiency and its medical repercussions in diabetic patients increases with ongoing metformin medication.Aim:To assess the vitaminB12 levels in type 2 diabetes mellitus patients on metformin and to determine the association with duration and dose metformin. Materials and Method: The present study was a Cross Sectional Observational Study conducted for a period of 6 months in department of General Medicine,Sree Mookambika Institute of Medical Sciences.There were 120 consecutive cases of Type 2 DM receiving metformin medication in the study group. Each patient's medical history was reviewed to identify the length of their metformin therapy and past dosages, and these dosages were vocally confirmed by the patients.Results were analyzed using SPSS 20.0 version and the association was tested using Chi square test. Results: The mean age group of patients included in the present study was 56.52 ± 11.3 years and the age group ranged from 32 to 76 years. The average duration of diabetes mellitus and metformin therapy were reported as 10.92±8.95 years and 8.66±7.24 years respectively. Vitamin B12 deficiency was seen in 49(40.83%)of the patients.When compared to other patients in the study population,patients with age greater than 50, duration of diabetes greater than 10 years, duration of metformin therapy greater than 5 years, and dose of metformin greater than 1000 mg/day had vitamin B12 deficiency.The association was found to be statistically significant (p0.05) with p values of 0.048,0.012,0.026,and 0.002, respectively.With diabetes for less than 10 years and more than 10 years, the mean serum levels of vitamin B12 were 183.518±94.75 and 152.384±36.26, respectively, and there was a significant correlation between the duration of diabetes exposure (p Value 0.004). Conclusion: Patients on metformin therapy frequently have vitamin B12 deficiency,especially those over the age of 50 years,with diabetes for longer than ten years, taking metformin for longer than five years, and receiving doses of more than 1000 mg/day. This strongly suggests routine screening for vitamin B12 in diabetic patients taking metformin.Before starting metformin,and afterwards on an annual basis,it is critical to screen for vitamin B12 insufficiency

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Prevalence of vitamin B12 deficiency in Indian type 2 diabetes subjects on metformin therapy

Cited by 5 publications

References 0 publications

The Frequency of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus Treated With Metformin for at Least Five Years

The Frequency of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus Treated With Metformin for at Least Five Years

Haematological Parameters and Vitamin B12 Levels in Type Ii Diabetic Patients on Metformin- A Prospective Case Control Study

Assessment of Serum Vitamin B12 Amongdiabetic Patients Under Treatment With Metformin in a Tertiary Care Centre

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