Prevalence of vitamin D deficiency and impact on clinical outcomes after kidney transplantation: a systematic review and meta-analysis

Yin, Saifu; Wang, Xianding; Li, Linde; Huang, Zhongli; Fan, Yu; Song, Ting; Lin, Tao

doi:10.1093/nutrit/nuab058

Cited by 9 publications

(8 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the best of our knowledge this is the first systematic review that summarizes the evidence of the long-term influence of vitamin D deficiency on the outcomes of kidney transplantation. A recent meta-analysis of 28 studies on the same subject by Yin et al [ 32 ] showed that vitamin D deficiency is common following KT and is associated with a high risk of mortality and adverse outcomes including infection and acute rejection. However, this study focused only on early vitamin D deficiency and assessed kidney graft function only one year post-operatively.…”

Section: Discussionmentioning

confidence: 99%

The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review

Koimtzis

Stefanopoulos

Brooker

et al. 2022

Life

View full text Add to dashboard Cite

The aim of this systematic review is to assess the impact of vitamin D on the outcomes of kidney transplantation and investigate whether its deficiency is associated with a negative impact. Methods: We conducted a systematic literature search in PubMed, Scopus and Cochrane databases, as well as gray literature. Ultimately, 16 articles with an average of 255.75 patients were included in this review. These articles compared the long-term outcomes of vitamin D deficiency and/or vitamin D supplementation therapy on kidney transplant recipients by assessing various parameters. Results: Most of the included studies showed a negative effect of vitamin D deficiency on kidney transplantation by being associated with a worse graft function, higher incidence of acute rejection episodes, higher incidence of proteinuria and lower overall graft and patient survival rate. Conclusions: We suggest that patients awaiting kidney transplantation have a careful evaluation in order to assess their vitamin D status and the optimal supplementation therapy. Regular follow-up of vitamin D levels post-transplant is also suggested. Prospective studies will be needed to establish the positive effects of vitamin D supplementation therapy on kidney transplant outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review

Koimtzis

Stefanopoulos

Brooker

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…As the liver and the kidney play crucial roles in the maintenance of the active vitamin D level, liver and kidney transplant recipients more frequently develop vitamin D deficiency [ 163 , 164 ]. Additionally, these patients have a higher ratio of vitamin D deficiency-associated comorbidities, such as fractures, diabetes, and infections [ 165 , 166 ].…”

Section: Vitamin D and Sirt1 In Relation To Non-communicable Diseases...mentioning

confidence: 99%

Interplay of Vitamin D and SIRT1 in Tissue-Specific Metabolism—Potential Roles in Prevention and Treatment of Non-Communicable Diseases Including Cancer

Németh

Patonai

Simon-Szabó

et al. 2023

IJMS

View full text Add to dashboard Cite

The importance of the prevention and control of non-communicable diseases, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer, is increasing as a requirement of the aging population in developed countries and the sustainability of healthcare. Similarly, the 2013–2030 action plan of the WHO for the prevention and control of non-communicable diseases seeks these achievements. Adequate lifestyle changes, alone or with the necessary treatments, could reduce the risk of mortality or the deterioration of quality of life. In our recent work, we summarized the role of two central factors, i.e., appropriate levels of vitamin D and SIRT1, which are connected to adequate lifestyles with beneficial effects on the prevention and control of non-communicable diseases. Both of these factors have received increased attention in relation to the COVID-19 pandemic as they both take part in regulation of the main metabolic processes, i.e., lipid/glucose/energy homeostasis, oxidative stress, redox balance, and cell fate, as well as in the healthy regulation of the immune system. Vitamin D and SIRT1 have direct and indirect influence of the regulation of transcription and epigenetic changes and are related to cytoplasmic signaling pathways such as PLC/DAG/IP3/PKC/MAPK, MEK/Erk, insulin/mTOR/cell growth, proliferation; leptin/PI3K-Akt-mTORC1, Akt/NFĸB/COX-2, NFĸB/TNFα, IL-6, IL-8, IL-1β, and AMPK/PGC-1α/GLUT4, among others. Through their proper regulation, they maintain normal body weight, lipid profile, insulin secretion and sensitivity, balance between the pro- and anti-inflammatory processes under normal conditions and infections, maintain endothelial health; balance cell differentiation, proliferation, and fate; and balance the circadian rhythm of the cellular metabolism. The role of these two molecules is interconnected in the molecular network, and they regulate each other in several layers of the homeostasis of energy and the cellular metabolism. Both have a central role in the maintenance of healthy and balanced immune regulation and redox reactions; therefore, they could constitute promising targets either for prevention or as complementary therapies to achieve a better quality of life, at any age, for healthy people and patients under chronic conditions.

show abstract

“…Following kidney transplantation, the levels of 25(OH)D was decreased especially in early postoperative period. [104][105][106][107][108] Low level of 25(OH)D was associated with increased rate and decreased time to infection of postoperative infection from bacteria, virus (cytomegalovirus and polyomavirus), and fungus. 104,106,108,109 Despite this, in some studies, there was no correlation between infection and levels of 25(OH)D when compared among group of population that separates into groups based on level of 25(OH)D. 85,110 This might be because different cut point of low and high level of 25(OH)D, the infectious prophylaxis strategy and incidence of infection among studies leading to different statistic outcomes.…”

Section: Vitamin D Air Pollution and Effects On Organ Transplantationmentioning

confidence: 99%

Impact of air pollution on postoperative outcomes following organ transplantation: Evidence from clinical investigations

Supphapipat,

Leurcharusmee,

Chattipakorn

et al. 2023

Clinical Transplantation

View full text Add to dashboard Cite

IntroductionAir pollution is a worldwide problem affecting human health via various body systems, resulting in numerous significant adverse events. Air pollutants, including particulate matter < or = 2.5 microns (PM2.5), particulate matter < or = 10 microns (PM10), ozone (O3), nitrogen dioxide (NO2), and traffic‐related air pollution (TRAP), have demonstrated the negative effects on human health (e.g., increased cerebrovascular, cardiovascular, and respiratory diseases, malignancy, and mortality). Organ transplant patients, who are taking immunosuppressive agents, are especially vulnerable to the adverse effects of air pollutants. The evidence from clinical investigation has shown that exposure to air pollution after organ transplantation is associated with organ rejection, cardiovascular disease, coronary heart disease, cerebrovascular disease, infection‐related mortality, and vitamin D deficiency.Objectives and methodThis review aims to summarize and discuss the association of exposure to air pollutants and serum 25‐hydroxyvitamin D level and outcomes after transplantation. Controversial findings are also included and discussed.ConclusionAll of the findings suggest that air pollution results in a hazardous environment, which not only impacts human health worldwide but also affects post‐transplant outcomes.

show abstract

Prevalence of vitamin D deficiency and impact on clinical outcomes after kidney transplantation: a systematic review and meta-analysis

Cited by 9 publications

References 57 publications

The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review

The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review

Interplay of Vitamin D and SIRT1 in Tissue-Specific Metabolism—Potential Roles in Prevention and Treatment of Non-Communicable Diseases Including Cancer

Impact of air pollution on postoperative outcomes following organ transplantation: Evidence from clinical investigations

Contact Info

Product

Resources

About