Prevalence of Vitamin D Deficiency in Adults With Sickle Cell Disease

Goodman, Benjamin; Artz, Nicole; Radford, Barbera; Chen, Ian A.

doi:10.1016/s0027-9684(15)30605-2

Cited by 39 publications

(45 citation statements)

References 22 publications

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“…The remaining studies were conducted in Turkey [50], Curaco [51], Saudi Arabia [52,53], Spain [26] or France[25,54]. In 10 studies, the primary aim of the paper was to assess the vitamin D status of the participants[2,25,26,44,45,49–53]. The primary aim in the remaining studies was to explore the association between vitamin D status and clinical outcomes such as bone mineral density (BMD) [43,46,54] and chronic pain [47,48].…”

Section: Resultsmentioning

confidence: 99%

“…Most of the articles included in this review (n = 11/15) studied pediatric/adolescent populations [2,26,45–52,54] and only four included a non-sickle cell comparison group [2,49,52,53]. Four studies assessed seasonal variation[2,25,44,45] and three studied dietary intake of vitamin D [2,49,52]. Definitions of vitamin D deficiency and insufficiency varied greatly in these studies.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies, whose primary aim was to assess vitamin D status in patients with SCD, included only adults; one was conducted in the United States [44], one in France[25], and Saudi Arabia [53]. Goodman et al enrolled 142 adults with SCD at two clinical centers in the US—Eastern Virginia Medical School (EVMS; n = 84) and University of Chicago (UC; n = 58).…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review

et al. 2015

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Vitamin D deficiency has emerged as a public health focus in recent years and patients with sickle cell disease (SCD) reportedly have a high prevalence of the condition. Our objectives were to summarize definitions of vitamin D deficiency and insufficiency used in the literature, and to determine the prevalence and magnitude of each in patients with SCD through a systematic review conducted according to PRISMA guidelines. From a PubMed search, 34 potential articles were identified and 15 met eligibility criteria for inclusion. Definitions of deficiency and insufficiency varied greatly across studies making direct comparisons difficult. This review provides evidence to suggest that suboptimal vitamin D levels are highly prevalent among those with SCD, far more so than in comparable non-SCD patients or matched control populations. Defining deficiency as vitamin D <20ng/mL, prevalence estimates in SCD populations range from 56.4% to 96.4%. When compared with results from the population-based National Health and Nutrition Examination Survey, however, the general African American population appeared to have a similarly high prevalence of vitamin D deficiency. African American patients with and without SCD were both substantially higher than that of Caucasians. What remains to be determined is whether there are adverse health effects for patients with SCD because of concurrent vitamin D deficiency.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review

et al. 2015

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“…This finding is in keeping with two recent reports about VDD in patients with SCD. First report by Goodman et al, [13] studied 148 patients with SCD and found 98% of patients had low (suboptimal) serum level (<30 ng/ml) and 60% had severe VD deficiency of <10 ng/ml. The second study by Arlet et al [14] was conducted on 56 patients with SCD found that VDD was detected in 26 (46%) patients with severe deficiency and another 26 (46%) with insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D deficiency in patients with sickle cell disease in Bahrain

Bakri

Garadah²,

Jaradat

et al. 2013

IJM

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Background: Patients with sickle cell disease (SCD) had a low serum level of vitamin D. The prevalence and the impact of this observation in SCD patient's in Bahrain is not clear. Aim: To assess the prevalence of vitamin D deficiency (VDD) in homozygous patients with SCD, and to evaluate the clinical and biochemical predictors of occurrence of VDD in such patients. Methods: We evaluated the vitamin D status in 70 patients with confirmed diagnosis of SCD and compared them with an age matched control group. Serum level of vitamin D, parathormone (PTH), calcium, phosphate, alkaline phosphatase, haemoglobin (Hb), and uric acid were measured. Linear regression analysis was performed to assess the relation between PTH and vitamin D level. Multiple regression analysis was performed to assess the predictive value of gender, body mass index (BMI) >24, serum level of uric acid>400 umol/Land estimated glomerular filtration rate (eGFR) <60, for occurrence of vitamin D deficiency in patients with SCD. Results: The mean age of the study group was 28.85 ±7.21 years compared with the control of 29.91 ±4.3 years, p=0.23. There were 40 (57%) female SCD patients compared with 39 (55%) in the control. In patients with SCD, the serum level of vitamin D was sufficient, >50 nmol/L in 4 (5%) patients, insufficient > 27.5 -≤50 nmol/L in 21 (30%) patients, deficient >12.5 -≤27.5 nmol/L 35 (50%) and profoundly deficient ≤12.5 nmol/L in 10(15%). In the control group, those with sufficient level of vitamin D were 53 (75%), insufficient 21(30%) deficient of 10 (15%) and none with profound deficiency, respectively. The serum level of PTH and alkaline phospahtase were significantly higher in the SCD group compared with control group. The eGFR, Hb and were significantly lower, serum level of uric acid was significantly higher (p < 0.05 but no significant difference between serum level of calcium or phosphate. Linear regression analysis showed inverse relation between VDD (<25 nmol/L) and PTH (r = -0.34, P<0.001). Multiple regression analysis showed female gender, BMI>24, hyperurecemia and low eGFR were positive predictor of VDD in patients with SCD. Conclusion:The risk of vitamin D deficiency among subjects with SCD-SS was 3.8 folds greater than control subjects; the prevalence of VDD in SCD was 95% and 25% in the control patients without SCD. On linear regression analysis, there is a significant inverse relation between serum levels of vitamin D and PTH in SCD patients. The female gender, BMI>24, hyperurecemia>400 umol/L and low eGFR<60 were positive predictor of VDD in patients with SCD.

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“…Other than its role in bone-mineral metabolism, clear evidence that variation in vitamin D measured as 25-hydroxyvitamin D (25(OH)D) influences health outcomes has been difficult to obtain [1]. Several reports from North America have documented lower 25(OH)D levels in patients with sickle cell disease (SCD) compared to age-matched controls [2–6]. A correlation between low 25(OH)D and severity of the course of SCD has also been observed and a recent case report described dramatic improvement in pain symptoms after vitamin D supplementation in a SCD patient with severe osteoporosis and profound vitamin D deficiency [2].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West Africa

et al. 2014

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BackgroundPatients with sickle cell disease in the USA have been noted to have lower levels of vitamin D – measured as 25-hydroxyvitamin D (25(OH)D) – compared to controls. Average serum 25(OH)D levels are also substantially lower in African Americans than whites, while population distributions of 25(OH)D among Jamaicans of African descent and West Africans are the same as among USA whites. The purpose of this study was to examine whether adult patients with sickle cell disease living in tropical regions had reduced 25(OH)D relative to the general population.MethodsWe analyzed serum 25(OH)D in stored samples collected from studies in Jamaica and West Africa of adult patients with sickle cell disease and adult population controls.ResultsIn samples of 20 Jamaicans and 50 West Africans with sickle cell disease mean values of 25(OH)D were 37% and 39% lower than controls, respectively. Metabolic abnormalities in the absorption and conversion pathways are possible causes for the consistent relative deficiency of 25(OH)D in sickle cell disease.ConclusionsLow 25(OH)D levels in tropical Africa where the burden of sickle cell disease is highest, deserve further investigation, and a randomized trial is warranted to address efficacy of supplementation.

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Prevalence of Vitamin D Deficiency in Adults With Sickle Cell Disease

Cited by 39 publications

References 22 publications

Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review

Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review

Prevalence of vitamin D deficiency in patients with sickle cell disease in Bahrain

Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West Africa

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