Prevalence of Von Willebrand Disease in Women of Reproductive Age With Heavy Menstrual Bleeding in Kashan, Iran, During 2019

Abdoli, Tahereh; Samimi, Mansooreh; Atoof, Fatemeh; Shayestehpour, Mohammad; Ehsani, Majid

doi:10.34172/ijer.2020.29

Cited by 1 publication

(1 citation statement)

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“…Both our cases had the history of heavy menstrual bleeding episodes. As an example of another bleeding disorder, a study reported a prevalence of 30% for endometriosis among patients with Von Willebrand Disease compared to 13% in the control group [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Monozygotic twin cases of endometriosis with Glanzmann thrombasthenia: a case report and review of literature

Rokhgireh

Mehdizadehkashi

Chaichian

et al. 2023

Orphanet J Rare Dis

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Background Glanzmann thrombasthenia (GT) is a rare bleeding disorder with a high prevalence in communities where consanguineous marriages are mainstream. Endometriosis is a chronic inflammatory disease, and its risk increases in women with menstrual periods of longer than six days. The phenotypic expression of endometriosis is determined by the frequency and rate of the menstrual flow, as well as genetic and environmental factors. Result and case presentation 14-year-old monozygotic twin sisters with GT who developed ovarian endometriosis were referred to Hazrat Rasoul Hospital due to severe dysmenorrhea. In ultrasonic examination, endometrioma cysts were reported in both patients. They both went under endometrioma cystectomy, and the bleeding was managed using antifibrinolytic drugs, followed by recombinant activated coagulation factor VII. Both were discharged after 3 days. In the ultrasound examination performed one year after the surgery, ovaries were normal in the first twin, while the second twin had a 28 × 30 hemorrhagic cyst in the left ovary. Discussion and conclusion Menstrual bleeding and genetic factors are two theories that could be related to GT and endometriosis association, and GT could be considered a risk factor for endometriosis.

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Section: Discussionmentioning

confidence: 99%