Prevalence of zinc deficiency and its clinical relevance among hospitalised elderly

Pepersack, Thierry; Rotsaert, Philippe; Benoit, Florence; Willems, Dominique; Fuss, Michel; Bourdoux, Pierre; Duchateau, Jean

doi:10.1016/s0167-4943(01)00186-8

Cited by 70 publications

(68 citation statements)

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“…Low circulating zinc (in plasma or white blood cells) is common among hospitalized elderly patients and has been associated with many diseases including DM and AD (Walter et al 1991;Prasad et al 1993;Singh et al 1998;Pepersack et al 2001;Kazi et al 2008;Brewer et al 2010). However, in some cases (e.g.…”

Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

“…As micronutrient deficiencies arise, decreased energy and motivation can further compromise dietary quality in a pathological cycle. For example, dietary zinc deficiency is known to decrease food intake in animal models and zinc supplementation improves taste acuity in elderly subjects (Pepersack et al 2001;Stewart-Knox et al 2008;Amani et al 2010). Inadequate zinc intake certainly contributes to deficiency in many elderly patients (Singh et al 1998;Pepersack et al 2001) but effects of chronic inflammation and age-related decline in zinc transport mechanisms may also contribute to a functional zinc deficiency (Turnlund et al 1986;Wong et al 2012).…”

Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

“…For example, dietary zinc deficiency is known to decrease food intake in animal models and zinc supplementation improves taste acuity in elderly subjects (Pepersack et al 2001;Stewart-Knox et al 2008;Amani et al 2010). Inadequate zinc intake certainly contributes to deficiency in many elderly patients (Singh et al 1998;Pepersack et al 2001) but effects of chronic inflammation and age-related decline in zinc transport mechanisms may also contribute to a functional zinc deficiency (Turnlund et al 1986;Wong et al 2012). For example, senescence of rat vascular smooth muscle cells involves decreased ZnT expression (Patrushev et al 2012) and an age-related decline in plasma zinc was associated with increased methylation of the ZIP6 promoter and an exaggerated inflammatory response in mice (Wong et al 2012).…”

Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

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Zinc and the aging brain

Nuttall

Oteiza

2013

Genes Nutr

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Alterations in trace element homeostasis could be involved in the pathology of dementia, and in particular of Alzheimer's disease (AD). Zinc is a structural or functional component of many proteins, being involved in numerous and relevant physiological functions. Zinc homeostasis is affected in the elderly, and current evidence points to alterations in the cellular and systemic distribution of zinc in AD. Although the association of zinc and other metals with AD pathology remains unclear, therapeutic approaches designed to restore trace element homeostasis are being tested in clinical trials. Not only could zinc supplementation potentially benefit individuals with AD, but zinc supplementation also improves glycemic control in the elderly suffering from diabetes mellitus. However, the findings that select genetic polymorphisms may alter an individual's zinc intake requirements should be taken into consideration when planning zinc supplementation. This review will focus on current knowledge regarding pathological and protective mechanisms involving brain zinc in AD to highlight areas where future research may enable development of new and improved therapies.

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Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

Section: Risk Of Zinc Deficiency In the Elderlymentioning

confidence: 99%

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Zinc and the aging brain

Nuttall

Oteiza

2013

Genes Nutr

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“…This prevalence of zinc deficiency was not detected in other studies carried out on hospitalized elderly, in which about one-third of subjects had plasma zinc below the cutoff value of deficiency (Schmuck et al, 1996;Pepersack et al, 2001).…”

Section: Discussionmentioning

confidence: 63%

“…Most of these studies have been performed among hospitalized or institutionalized elderly or focussed mainly on the relationship between zinc status and immune function (Pepersack et al, 2001;Mitchell et al, 2003;Chandra, 2004), while data in elderly free living people are scarce. Results are heterogeneous and conflicting but in agreement with the importance of zinc supplementation in case of deficiency or in case of altered metabolism associated with reduced immune response (Turnlund et al, 1986;Cousin, 1989;McClain and Stuart, 1990;Bales et al, 1994;Sturniolo et al, 1994;Fortes et al, 1998;Brown et al, 2001;Pepersack et al, 2001;Mitchell et al, 2003;Chandra, 2004).…”

Section: Discussionmentioning

confidence: 99%

Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study

et al. 2007

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Objective: To assess the effects of zinc supplementation on vitamin status in middle-aged and older volunteers. Subjects/Methods: Three hundred and eighty-seven healthy middle-aged (55-70 years) and older (70-85 years) men and women, randomly allocated to three groups to receive 15 or 30 mg Zn/day or placebo for 6 months. Dietary intake was assessed by means of a validated 4-day recall record. Fasting blood samples were simultaneously analysed for levels of plasma retinol and a-tocopherol by high-performance liquid chromatography. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatized immunoanalyser. Biochemical measurements were performed at baseline and after 3 and 6 months of zinc supplementation. Results: Plasma vitamin A levels were significantly increased proportionally with zinc dose and period of treatment, particularly at 6 months (for 15 mg Zn/day, Po0.05; for 30 mg Zn/day, Po0.0001); no significant changes were observed in the placebo group. There was no effect of zinc supplementation on vitamin E/cholesterol ratio and erythrocyte folates. Conclusions: Our results show that a long-term zinc supplementation increases plasma vitamin A levels in middle-aged and older people of similar characteristics to those involved in this study. Moreover, supplementation influences serum zinc levels but does not affect erythrocyte zinc concentration and both plasma vitamin E and erythrocyte folate status.

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Bioavailability, antioxidant and immune‐enhancing properties of zinc methionine

Chien¹,

Zafra-Stone²,

Bagchi³

et al. 2006

BioFactors

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Although a large number of transition metals and cations remarkably induce oxidative deterioration of biological macromolecules including lipids, proteins and DNA, the trace element zinc acts as a novel dietary supplement and an essential micronutrient, and serves a wide range of biological functions in human and animal health. Zinc promotes antioxidant and immune functions, stabilizes and maintains the structural integrity of biological membranes, and plays a pivotal role in skin and connective tissue metabolism and repair. Zinc is an integral constituent of a large number of enzymes including antioxidant enzymes, and hormones including glucagon, insulin, growth hormone, and sex hormones. High concentrations of zinc are found in the prostate gland and choroids of the eye. Zinc deficiency leads to biochemical abnormalities including the impairments of growth, dermal, gastrointestinal, neurologic and immunologic systems. Given its superior bioavailability, antioxidant and immune-enhancing properties, zinc methionine may serve as a novel dietary supplement to promote health benefits in humans and animals.

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Prevalence of zinc deficiency and its clinical relevance among hospitalised elderly

Cited by 70 publications

References 16 publications

Zinc and the aging brain

Zinc and the aging brain

Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study

Bioavailability, antioxidant and immune‐enhancing properties of zinc methionine

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