Prevalence of Zinc Deficiency in Japanese Patients on Peritoneal Dialysis: Comparative Study in Patients on Hemodialysis

Shimizu, Satoshi; Tei, Ritsukou; Okamura, Mitsu; Takao, Nobuteru; Nakamura, Yoshihiro; Oguma, Hidetaka; Maruyama, Takashi; Takashima, Hiroyuki; Abe, Masanori

doi:10.3390/nu12030764

Cited by 20 publications

(10 citation statements)

References 41 publications

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“…Some clinic investigations also showed that zinc supplements ameliorates TNFα,IL-1beta and Hs-CRP in hemodialysis patients [39]. However, in those studies, no signi cant correlation was found of serum zinc levels with peritoneal dialysis adequacy [9,40]. In this study we found that zinc levels in whole blood are signi cantly different between patients with high tKt/V patients and those with low tKt/V patients.…”

contrasting

confidence: 49%

“…Peritoneal dialysis (PD) patients are in poorer nutrition situation compared to patients on hemodialysis (HD) due to the loss of albumin in the PD e uent [7,8]. Zinc de ciency is common and prevalent in PD patients due to inadequate dietary intake, tubular reabsorption impairment, hypo-proteinemia, reduced gastrointestinal zinc absorption and remove from the PD e uent [9]. There are several cross-section studies revealing the prevalence of zinc in peritoneal dialysis patients worldwide including Japan, Mexico, United states and European countries [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Zinc de ciency is common and prevalent in PD patients due to inadequate dietary intake, tubular reabsorption impairment, hypo-proteinemia, reduced gastrointestinal zinc absorption and remove from the PD e uent [9]. There are several cross-section studies revealing the prevalence of zinc in peritoneal dialysis patients worldwide including Japan, Mexico, United states and European countries [9][10][11]. In contrast, there are few reports on dietary zinc intake and zinc concentration in patients on PD in China.…”

Section: Introductionmentioning

confidence: 99%

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Zinc Status is Related To Dialysis Adequacy In Peritoneal Dialysis Patients: A Cross-Sectional Study In Central China

Zhang

Zhao

et al. 2022

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Background: Zinc displays an essential role in regulation of inflammation and redox oxidative stress and patients on peritoneal dialysis (PD) are prone to develop zinc deficiency due to decreased dietary intake and losses via PD effluent and urinate. This study was aimed to evaluate the prevalence rate of zinc level in Chinese patients on PD and the relationship between zinc level and total Kt/V (tKt/V) on PD; Methods: A cross-sectional study of a cohort of 116 patients with end-stage kidney disease (ESKD) receiving PD was conducted. Peritoneal dialysis Kt/V were identified and patients were grouped as high tKt/V (＞1.7) ( n=78) group and low tKt/V（＜1.7）(n=38) group. The zinc level in whole blood were measured using atomic absorption spectroscopy（AAS）; Results: The zinc level in whole blood showed significantly higher values in patients with high tKt/V than those with low tKt/V (5.47±0.47 and 5.02±0.35, p=0.031, respectively). Age, zinc, albumin and cholesterol level were identified as independent predictors of Kt/V in PD patients by multivariate analysis. The prognostic value of zinc of high tKt/V was revealed as an area under the curve (AUC) of 0.799 (95% CI :0.717-0.881, p＜0.001) with a sensitivity of 80.8% and specificity of 73.7%. Compared with albumin and cholesterol, Delong’test was empolyed and the results showed that zinc in whole can predict the better adequacy of PD significantly (p＜0.05); Conclusions: Zinc level in whole blood are low in patient undergoing peritoneal dialysis. Low zinc concentration is associated with low tKt/V in PD patients, suggesting that zinc level in whole blood may serve as an independent factor of dialysis quality of PD patients.

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confidence: 49%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Zinc Status is Related To Dialysis Adequacy In Peritoneal Dialysis Patients: A Cross-Sectional Study In Central China

Zhang

Zhao

et al. 2022

Preprint

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“…Zinc is reported to play a crucial role in the immune According to a study by Satoshi Shimizu and colleagues, the prevalence of clinical zinc deficiency in the hemodialysis population was about 46.4%. They indicated that even patients who have undergone hemodialysis for a short duration showed signs of zinc deficiency and immune disorders (9). We found a higher prevalence of zinc deficiency among hemodialysis patients (57.83%).…”

Section: Discussionmentioning

confidence: 42%

Zinc deficiency may play a crucial role in dialysis-associated bacterial infections

et al. 2020

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Introduction: Systemic bacterial infections are a common cause of mortality and morbidity in hemodialysis patients. Zinc has a critical role in several immune system functions. Patients who have enough amounts of zinc are able to better face infections caused by various pathogens in comparison to those with zinc insufficiency Objective We sought to assess the role of zinc deficiency in dialysis-associated bacterial infections. Patients and Methods: Eighty-Three adult patients with end-stage renal disease (ESRD) on hemodialysis including 43 patients with bacterial infectious complications and 40 non-infected patients as well as 41 healthy individuals were enrolled. Clinical data, laboratory values including serum zinc level and imaging findings were collected. SPSS was utilized to analyze the data with a significance cutoff set at P < 0.05. Results: Out of 124 participants, 80 (64.51%) were males and 44 (35.49%) were females. The mean age of infected hemodialysis group, non-infected hemodialysis group, and healthy controls were 50.8 ± 16.25, 49.1 ± 18.1, and 56.3 ± 18.2 years, respectively. Catheter site infection (37.3%) and urinary tract infection (30.2%) were the most common infections. The mean serum zinc concentration was significantly lower in the infected patients, compared to non-infected patients and healthy individuals (P < 0.001). Conclusion: The ESRD patients on hemodialysis have lower serum zinc levels which are associated with increased risk of bacterial infection. The role of screening for zinc deficiency and use of supplemental zinc in these patients need to be studied.

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“…Serum Zn levels tend to be low in patients undergoing hemodialysis because these patients are often undernourished owing to chronic inflammation, uremia, and food restrictions. Shimizu et al reported that the mean serum Zn level in Japanese patients undergoing hemodialysis was 61 ± 10.5 μg/dL, and half of all patients had serum Zn levels < 60 μg/dL [11]. In our hospital,4 0% of all patients had serum zinc levels < 60 μg/dL (data not shown).…”

Section: Discussionmentioning

confidence: 44%

The association between hypozincemia and aortic stenosis prevalence in hemodialysis patients: a single-center cross-sectional study

et al. 2020

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Background Hypozincemia contributes to phosphate-induced vascular calcification in model animals of renal failure, but the association between hypozincemia and aortic stenosis (AS) prevalence in patients with end-stage kidney disease remains unreported in clinical settings. Methods To investigate the association between hypozincemia and AS prevalence in patients undergoing hemodialysis, we designed a single-center cross-sectional study. Our outcome “AS” was defined as prevalence of moderate or severe AS or surgical history for AS. Depending on serum zinc levels, we divided patients undergoing hemodialysis into deciles. The association between hypozincemia and AS prevalence was analyzed via logistic regression adjusted for age, sex, dialysis vintage, diabetes history, serum albumin, and history of taking calcium-containing phosphate binder. Results Ninety-three patients undergoing hemodialysis were eligible. The mean serum zinc level was 61.3 ± 13.9 μg/dL. Twelve patients who belonged to 1st decile had serum zinc levels ≤ 48 μg/dL. Of these twelve patients, six patients (50 %) had AS. On the other hand, of eighty one patients who belonged to 2nd–10th deciles (serum zinc levels > 48 μg/dL), thirteen patients (16 %) had AS. Hypozincemia (serum zinc levels ≤ 48 μg/dL) was associated with AS prevalence (P = 0.038; odds ratio 4.43; 95% confidence interval 1.09–18.0). Conclusions AS was more prevalent in patients undergoing hemodialysis with severe hypozincemia in our cross-sectional study, although interventional studies are required to elucidate the benefit of zinc supplementation for AS progression.

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Prevalence of Zinc Deficiency in Japanese Patients on Peritoneal Dialysis: Comparative Study in Patients on Hemodialysis

Cited by 20 publications

References 41 publications

Zinc Status is Related To Dialysis Adequacy In Peritoneal Dialysis Patients: A Cross-Sectional Study In Central China

Zinc Status is Related To Dialysis Adequacy In Peritoneal Dialysis Patients: A Cross-Sectional Study In Central China

Zinc deficiency may play a crucial role in dialysis-associated bacterial infections

The association between hypozincemia and aortic stenosis prevalence in hemodialysis patients: a single-center cross-sectional study

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