Prevalence ofCryptococcus neoformans in clinical specimens

Dorko, Erik; Kmeťová, M; Dorko, F; I, Bracoková; Danko, Ján; Švický, E.; Tkáčiková, Ľudmila

doi:10.1007/bf02817564

Cited by 14 publications

(2 citation statements)

References 22 publications

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“…Of these, 143 studies were included in the data analysis (Tables, references, Supplemental Digital Contents 1, http://links.lww.com/INF/F353; 2, http://links.lww.com/INF/F354) and 25 did not meet the inclusion criteria. 8,13,15,17–38 A total of 1048 children were included in the data analysis. The 103 case reports of pediatric cryptococcal disease are summarized in Table, Supplemental Digital Content 1, http://links.lww.com/INF/F353.…”

Section: Resultsmentioning

confidence: 99%

Pediatric Cryptococcosis

Gifford,

Jayawardena,

Carlesse

et al. 2024

Pediatric Infectious Disease Journal

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Background: Seroprevalence studies have shown that 70% of children are exposed to Cryptococcus, the most common cause of meningitis in people living with human immunodeficiency virus (HIV), but reported pediatric disease prevalence is much lower than in adults. Methods: PubMed and Ovid Global Health databases were searched with the terms “cryptococcosis,” “cryptococcal meningitis,” “Cryptococcus neoformans” or “Cryptococcus gattii.” All studies reporting pediatric specific data in the English language from 1980 up until December 2022 were included. Results: One hundred sixty-eight publications were reviewed totaling 1469 children, with the majority reported from Africa (54.2%). Sixty-five percent (961) were HIV positive, 10% (147) were non-HIV immunocompromised and 19% (281) were immunocompetent. Clinical signs and symptoms were only reported for 458 children, with fever (64%), headache (55%) and vomiting (39%) being the most common. Most children (80%) suffered from meningoencephalitis. Lung involvement was rarely described in HIV-positive children (1%), but significantly more common in the non-HIV immunocompromised (36%) and immunocompetent (40%) groups (P < 0.0001). Only 22% received the recommended antifungal combination therapy, which was significantly higher in immunocompetent children than those with HIV (39% vs. 6.8%; P < 0.0001). Overall mortality was 23%. A significant higher mortality was observed in children with HIV compared with immunocompetent children (32% vs. 16%; P < 0.001), but not compared with children with non-HIV immunosuppression (25). Conclusions: This is the largest review of pediatric cryptococcosis with new observations on differences in clinical presentation and outcome depending on the underlying condition. The lack of granular clinical data urges prospective clinical epidemiological studies for improved insight in the epidemiology, management and outcome of cryptococcosis in children.

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Section: Resultsmentioning

confidence: 99%

Pediatric Cryptococcosis

Gifford,

Jayawardena,

Carlesse

et al. 2024

Pediatric Infectious Disease Journal

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“…The bacterial isolates were further studied for their morphological and biochemical characteristics. Dorko et al, (2000) reported that Cryptococcus neoformans are white, grey in colour, smooth in texture and had raised colony.…”

Section: Characterization Of Bacterial Isolatesmentioning

confidence: 99%

Assessing the Plant Growth Promoting Activity of Phylloplane Associated Plant Bacteria of Rice

Devi¹,

Gomathy²,

Sabarinathan³

et al. 2020

Int.J.Curr.Microbiol.App.Sci

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Candida-associated denture stomatitis

et al. 2001

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Candida-associated denture stomatitis was demonstrated by its cultivation in 171 out of 240 patients examined with partial or total dentures. After taking smears from lesions of the oral mucosa (tongue, cheeks, palate) and the contiguous denture surface by cotton wool swabs and inoculating them onto Sabouraud glucose agar and CHROMagar Candida, individual yeast species were identified by a germ tube, filamentous, and assimilation tests employing the commercial kit AuxaColor. Seven Candida species were identified in smears from the oral mucosa lesions and the contiguous denture surface: C. albicans (95 patients), C. tropicalis (26), C. parapsilosis (20), C. krusei (14), C. guilliermondii (12), C. lusitaniae (1) and C. freyschusii (1). Diabetes mellitus, neoplastic diseases, chemotherapy, radiotherapy, and broad-spectrum antibiotic therapy were identified as some of the large number of factors predisposing patients to stomatitis prothetica.

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Prevalence ofCryptococcus neoformans in clinical specimens

Cited by 14 publications

References 22 publications

Pediatric Cryptococcosis

Pediatric Cryptococcosis

Assessing the Plant Growth Promoting Activity of Phylloplane Associated Plant Bacteria of Rice

Candida-associated denture stomatitis

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