Prevalence, pandemic, preventions and policies to overcome antimicrobial resistance

Alotaibi, Ghallab

doi:10.1016/j.sjbs.2024.104032

Saudi Journal of Biological Sciences

2024

DOI: 10.1016/j.sjbs.2024.104032

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Prevalence, pandemic, preventions and policies to overcome antimicrobial resistance

Ghallab Alotaibi

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2024

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Experimental Phage Evolution Results in Expanded Host Ranges Against MDR and XDRKlebsiella pneumoniaeIsolates

Ghatbale,

Blanc,

Leonard

et al. 2024

Preprint

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Bacterial pathogens are becoming greater threats given the rise in antibiotic resistance, where traditional therapies may no longer work to cure some infections. Chief amongst these multidrug resistant infections (MDR) and extensively drug-resistant infections (XDR) is Klebsiella pneumoniae, which is known to sometimes harbor genetic elements that render it incredibly difficult to treat with conventional antibiotics. Treatments like bacteriophages have not had much success against such pathogens because resistance to the phages used often develops rapidly. We adapted a co-evolutionary technique to develop K. pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates. In as few as 30 days, we were able to vastly expand the host ranges of K. pneumoniae phages against MDR and XDR clinical isolates and that maintain their infectivity over clinically relevant time periods. By adapting these established techniques to clinical MDR and XDR K. pneumoniae isolates, we believe we can establish similar techniques for expanding phage host ranges against most antibiotic-resistant bacteria. As such, phages can be viable alternatives to antibiotics when antibiotic resistance exists in hospitals and communities.

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Experimental Phage Evolution Results in Expanded Host Ranges Against MDR and XDRKlebsiella pneumoniaeIsolates

Ghatbale,

Blanc,

Leonard

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Prevalence, pandemic, preventions and policies to overcome antimicrobial resistance

Cited by 1 publication

References 73 publications

Experimental Phage Evolution Results in Expanded Host Ranges Against MDR and XDRKlebsiella pneumoniaeIsolates

Experimental Phage Evolution Results in Expanded Host Ranges Against MDR and XDRKlebsiella pneumoniaeIsolates

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