Prevalence pattern of key polymorphisms in the Vitamin D receptor gene among patients of Type 2 diabetes mellitus in Northeast India

Sarma, Debajit; Chauhan, Vikram Singh; Saikia, Kandarpa Kumar; Sarma, Partha Pratim; Nath, Sukanta

doi:10.4103/ijem.ijem_213_17

Cited by 17 publications

(9 citation statements)

References 21 publications

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“…Contrary, Angel et al [39] did not support the hypothesis of a significant contribution of Bsml, Apal and Taql VDR polymorphisms in the etiology of T1DM of Chilean patients. Interestingly, the study of Sarma et al [25] in T2DM patients from north eastern India showed that body weight and BMI were significantly associated with BsmI and TaqI polymorphisms. BsmI was associated with HbA1C, and the frequency of the heterozygous genotype of the BsmI polymorphism was significantly higher in T2DM patients than in controls.…”

Section: Discussionmentioning

confidence: 99%

“…In spite of the existence of some studies examining the association between VitD levels, VDR polymorphisms, and T2DM in different populations, the results are not clear [13,14,15,16,17,18,19,20,21,22,23,24,25]. Therefore, in this study we aimed to evaluate the association between 25-hydroxy vitamin D [25(OH)D] levels and polymorphisms in the VDR gene (ApaI, BsmI, FokI, and TaqI) in a group of T2DM Brazilian patients, according to their body mass index (BMI).…”

Section: Introductionmentioning

confidence: 99%

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Lower Vitamin D Levels, but Not VDR Polymorphisms, Influence Type 2 Diabetes Mellitus in Brazilian Population Independently of Obesity

et al. 2019

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Background and Objectives: Vitamin D levels have been associated with a diversity of diseases, including obesity. Vitamin D presents a pleiotropic action, and can regulate insulin secretion and inflammatory responses. Vitamin D receptor (VDR) gene polymorphisms are involved in the gene expression regulation and have been associated with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between the polymorphisms ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810), and TaqI (rs731236) in the VDR gene in people diagnosed with T2DM, and plasma 25-hydroxivitamin D levels [25(OH)D]. Materials and Methods: A total of 101 T2DM patients and 62 gender, age, and body mass index (BMI) matched non-diabetic controls were included in this study. Molecular analyzes were performed by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The plasma 25(OH)D levels were measured by high performance liquid chromatography. Results: The plasma 25(OH)D levels were lower in T2DM patients (17.2 (16.6) ng/mL) when compared with the control subjects (30.8 (16.2) ng/mL, p < 0.0001), independently of obesity status. We found no difference between genotypic and allelic frequencies of the VDR polymorphisms when comparing the T2DM group and control group (p > 0.05 for all), and did not show any association with plasma 25(OH)D levels. Conclusions: These results suggest that T2DM is associated with lower plasma 25(OH)D levels, which are not related to BMI and VDR gene polymorphisms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lower Vitamin D Levels, but Not VDR Polymorphisms, Influence Type 2 Diabetes Mellitus in Brazilian Population Independently of Obesity

et al. 2019

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“…The current and previously published meta-analyses involving studies were shown in Table 2, Supplemental Digital Content, http://links.lww.com/MD/G216. 56 studies met our requirements, [26,27,28–34,19,35–80] of which 37 studies reported the VDR BsmI (5586 cases and 6484 controls), 31 studies examined the VDR FokI (6525 cases and 7464 controls), 19 studies investigated the VDR ApaI (2593 cases and 3557 controls), and 24 studies explored the VDR TaqI (3221 cases and 4027 controls) with T2DM risk, as shown in Figure 1 and Table 4, Supplemental Digital Content, http://links.lww.com/MD/G216. Among these studies, 25, 22, 6, and 4 of the studies were conducted to analyze Asians, Caucasians, Indians, and mixed populations, respectively.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of association studies and a systematic review and meta-analysis of VDR polymorphisms in type 2 diabetes mellitus risk

et al. 2021

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Numerous original studies and 4 published meta-analyses have reported the association between the Vitamin D receptor ( VDR ) BsmI, FokI, ApaI, and TaqI polymorphisms and type 2 diabetes mellitus (T2DM) risk. However, the results were inconsistent. Therefore, an updated meta-analysis was performed to further explore these issues. To further explore the association between the VDR BsmI, FokI, ApaI, and TaqI polymorphisms and T2DM risk. PubMed, EMBASE, Scopus, and Wanfang databases were searched. The following search strategy were used: ( VDR OR vitamin D receptor) AND (polymorphism OR variant OR mutation) AND (diabetes OR mellitus OR diabetes mellitus). Pooled crude odds ratios with 95% confidence intervals were applied to evaluate the strength of association in 5 genetic models. Statistical heterogeneity, the test of publication bias, and sensitivity analysis were carried out using the STATA software (Version 12.0). To evaluate the credibility of statistically significant associations, we applied the false-positive report probabilities (FPRP) and Bayesian false discovery probability (BFDP) test. Overall, the VDR BsmI polymorphism was associated with a significantly decreased T2DM risk in Asians; the VDR FokI polymorphism was associated with a significantly decreased T2DM risk in Asians, African countries, and Asian countries; the VDR ApaI polymorphism was associated with a significantly decreased T2DM risk in Caucasians and North American countries. On the VDR ApaI polymorphism, a significantly increased T2DM risk was found in a mixed population. However, when we further performed a sensitivity analysis, FPRP, and BFDP test, less-credible positive results were identified (all FPRP > 0.2 and BFDP > 0.8) in any significant association. In summary, this study strongly indicates that all significant associations were less credible positive results, rather than from true associations.

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“…The results of another study show that body weight and BMI were significantly associated with polymorphisms Bsm1 and Taq1, while Bsm1 strongly correlated with elevated HbA1c level. The frequency of the heterozygous genotype of the Bsm1 polymorphism was significantly greater in type 2 diabetics than in controls [70]. A study of this parameter in a group of patients with T2D from India revealed that it was Taq1 and Bsm1 polymorphisms that were closely associated with diabetes [71].…”

Section: Vitamin D Deficiency and Type 2 Diabetes Mellitusmentioning

confidence: 96%

Vitamin D Deficiency and Diabetes Mellitus

Shymanskyi¹,

Lisakovska²,

Mazanova³

et al. 2020

Vitamin D Deficiency

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Vitamin D (VD) is a molecule that can be synthesized directly in the humans' body or enter the organism with food in the form of inactive precursors. To exert its biological action, VD undergoes two-stage hydroxylation (at the 25th and 1st position) catalyzed by cytochromes P450, the presence of which has already been shown in almost all tissues of the human body. The product of hydroxylation is hormone-active form of vitamin D-1,25(OH) 2 D. 1,25(OH) 2 D binds to specific vitamin D receptor (VDR) and regulates the expression of genes involved in bone remodeling (classical function) and genes that control immune response, hormone secretion, cell proliferation, and differentiation (nonclassical functions). VD deficiency is prevalent around the globe and may be one of the key factors for diabetes development. The direct association between vitamin D deficiency and type 1 (T1D) and type 2 (T2D) diabetes has been proven. Detection of VDR in pancreas and adipose tissue, skeletal muscles, and immune cells allowed implying the antidiabetic role of vitamin D by enhancing insulin synthesis and exocytosis, increasing the expression of the insulin receptor, and modulating immune cells' functions. This chapter summarizes data about relationship between VD insufficiency/deficiency and development of T1D and T2D, and their complications.

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Prevalence pattern of key polymorphisms in the Vitamin D receptor gene among patients of Type 2 diabetes mellitus in Northeast India

Cited by 17 publications

References 21 publications

Lower Vitamin D Levels, but Not VDR Polymorphisms, Influence Type 2 Diabetes Mellitus in Brazilian Population Independently of Obesity

Lower Vitamin D Levels, but Not VDR Polymorphisms, Influence Type 2 Diabetes Mellitus in Brazilian Population Independently of Obesity

Evaluation of association studies and a systematic review and meta-analysis of VDR polymorphisms in type 2 diabetes mellitus risk

Vitamin D Deficiency and Diabetes Mellitus

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