Prevalence Patterns of Community-based and Nosocomial Urinary Tract Infection Caused by Escherichia coli

Rafique, Sobia; Mehmood, A; Qayyum, Mazhar; Qazilbash, Ali Abbas

doi:10.3923/pjbs.2002.494.496

Cited by 5 publications

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“…Patients are overcrowded in hospital units and are being looked after by busy physicians and surgeons thus further contributing to the increased incidence of hospital acquired infections. 2,3 We believe that resistance to cephalosporins is the main cause of failure in the treatment of hospital acquired infections due to E. Coli and K. pneumoniae. Because of wide spread use of this group of antibiotics, Entetrobacteriacea have evolved various mechanisms of resistance, the most important of them being Extended Spectrum Beta Lactamases (ESBL).…”

Section: Introductionmentioning

confidence: 99%

“…2 ESBLs have as much as 200 variants including TEM (Temoria) and SHV (Sulphydryl).⁴ These enzymes are called extended spectrum because they hydrolyse a wide variety of beta-lactam antibiotics including penicillins, cephalosporins and monobactam. 3 These enzymes are mostly plasmid mediated in E.coli and K.pneumoniae⁴. The hallmark of these enzymes is their inhibition by beta lactamase inhibitors like clavulanic acid, sulbactam and tazobactam.⁵ Hospital acquired infection rates are different in various parts of the world and depend upon many factors like severity of the disease, immune status of the patient and antibiotic administration in hospitals.⁵ , ⁶ Correct detection and timely surveillance of ESBL producing Enterobacteriaceae in the hospital can greatly influence emperical therapy of high risk patients with severe hospital acquired infection.⁵ , ⁷ , 12 The main aim of our study was to determine the frequency of ESBL producing E.coli and K.pneumoniae to reduce the antibiotic therapy failure and, therefore to minimise hospital stay, mortality, morbidity and economy burden.⁸ , ⁹…”

Section: Introductionmentioning

confidence: 99%

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E-Coli and Klebsiella Pneumoniae

Bari

Akram

Shah

et al. 2015

TPMJ

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Objectives: To evaluate extended spectrum betalactamase (ESBL) in E.coli andKlebsiella pneumoniae in bacterial cultures and its frequency at LRH. Study Design: Crosssectional analytical study. Setting: Lady Reading Hospital, Peshawar. Period: June 2013 toDecember 2013. Methodology: Total of 1037 bacterial isolates including 614 E.coli and 423 ofKlebsiellapneumoniae were evaluated. All cases were subjected to double disc diffusion methodfor ESBL detection using amoxacilln-clavulanic acid and a third generation cephalosporin asall ESBLs are hydrolysed by clavulanic acid. The data were analysed using SPSS-16. Results:Out of 1037 cases five ninety two (55%) were males and four fourty five (45%) were females. Ofthese, E. Coli were 614 (59.2%) and K. Pneumoniae were four twenty three (40.8%). Of these1037 isolates, four hundred & ninety five(47.7%) tested positive for ESBL enzyme. Frequencyof ESBL positivity in E.coli isolates was 264 (43%) and in Klebsiellapneumoniae isolates was231 (54.6%).Frequency of ESBL in pus was 34.3%(152/395),in urine, it was 31.8%(141/368),in blood it was 28.6%(127/233) and in sputum it was 5.1% (23/41). Unit wise frequency ofESBL was surgical & allied 24.6% (109/283), medical and allied 21.4%( 95/241), paediatrics18.5% (82/203), obstetrics & gynaecology 23.2%( 103/178) and outpatients 12.1 %(54/132).No significant correlation between ESBL positivity, gender, unit or specimen was found.Conclusion: ESBL positive isolates of E.coli and K.pneumoniaeshould be properly detected inroutine laboratory workflow to avoid unnecessary use of otherwise effective antibiotics.Theseresults indicate that such organisms are highly prevalent in our Hospital and need immediateinfection control measures to reduce their further spread.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

E-Coli and Klebsiella Pneumoniae

Bari

Akram

Shah

et al. 2015

TPMJ

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Urinary Tract Infection among Iranian Older Adults: a Systematic Review and Meta-Analysis

et al. 2020

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Antimicrobial Susceptibility Pattern of Escherichia coli Isolated from Uninary Tract Infected Patients Attending Bir Hospital

Sharma

Bhatta

Shrestha

et al. 2013

Nepal Journal of Science and Technology

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Antibiotic resistance among uropathogens is emerging public health problem. This study was done for assessing antibiotic and multidrug resistance (MDR) patterns of Escherichia coli at Bir Hospital, Kathmandu, among suspected urinary tract infection (UTI) patients from January to March, 2011. Altogether, 739 urine samples were analysed by semi-quantitative culture method and uropathogens were identified by conventional methods. E. coli was tested (109 samples) for antimicrobial susceptibility by Kirby Bauer disc diffusion method as per Clinical and Laboratory Standard Institute (CLSI) guidelines. Out of 739 samples, 27.3% gave significant growth while 3.1% and 29.2% samples gave mixed and non-significant growth respectively. E. coli was found to be most predominant isolate (54.0%) followed by coagulase negative Staphylococci (CoNS) (21.3%) and Enterococcus spp. (7.3%). Nitrofurantoin was found to be the most effective antibiotic followed by ciprofloxacin and ofloxacin while cephalexin was least effective. Out of 109 E. coli isolates, 90.8% were MDR strains and most of the isolates had a very high multiple antibiotic resistance (MAR) index, suggesting the origin of the isolates to be of high antibiotic usage. E. coli showed higher rate of resistance towards commonly used oral antibiotics. However, nitrofurantoin is still active against organisms. Thus, nitrofurantoin could be the choice for empirical therapy of UTI.

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Prevalence Patterns of Community-based and Nosocomial Urinary Tract Infection Caused by Escherichia coli

Cited by 5 publications

References 0 publications

E-Coli and Klebsiella Pneumoniae

E-Coli and Klebsiella Pneumoniae

Urinary Tract Infection among Iranian Older Adults: a Systematic Review and Meta-Analysis

Antimicrobial Susceptibility Pattern of Escherichia coli Isolated from Uninary Tract Infected Patients Attending Bir Hospital

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