Prevalence, predictors, and outcomes of major congenital anomalies: A population-based register study

Al‐Dewik, Nader; Samara, Muthanna; Younes, Salma; Al-Jurf, Rana; Nasrallah, Gheyath K.; Al-Obaidly, Sawsan; Salama, Husam; Olukade, Tawa; Hammuda, Sara; Marlow, Neil; Ismail, Mohamed A.; Nada, Taghreed Abu; Qoronfleh, M. Walid; Thomas, Binny; Abdoh, Ghassan; Abdulrouf, Palli Valapila; Farrell, Thomas S. C.; Qubaisi, Mai Al; Rifai, Hilal Al

doi:10.1038/s41598-023-27935-3

Cited by 18 publications

(14 citation statements)

References 22 publications

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“…In this study, a proportion of 2.2% of malformed neonates from consanguineous marriages was noted, this figure being significantly lower than the rate of consanguinity of 8% reported in India [30] 37.5% in Qatar [31] This difference is attributable to the impact of social-cultural practices specific to different populations. Consanguinity is thought to play a significant role in increasing the prevalence of genetic disorders, mainly autosomal recessive disorders [32] According to World Health Organization (WHO) [3] data, consanguinity contributes to an increase in the prevalence of genetically rare congenital malformations by doubling the risk of such malformations in children born to first cousins.…”

Section: Etiological Factorscontrasting

confidence: 66%

Visible Congenital Malformations in Ouagadougou (Burkina Faso)

Nagalo,

Konaté,

Douamba

et al. 2023

AJPR

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Objective: To gain a better understanding of congenital malformations and to help reduce neonatal morbidity and mortality, particularly in a context of resource-limited countries. Methods: This descriptive cross-sectional study with retrospective and prospective data collection over the period from November 2019 to January 2022 was conducted in the Neonatology Unit of the Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle of Ouagadougou, Burkina Faso (West Africa). Records of neonates with a visible malformation, neonates whose parents were accessible by telephone were included. Results: The frequency of congenital malformations was 8.4%. They affected females (51.1%), first-born siblings (25%) and full-term babies (69.6%). Osteoarticular malformations (38%), those of the eye, ear, face and neck (22.81%), followed by those of the digestive system (21.64%) were the most frequent. The case-fatality rate was 51.5%. Conclusion: Visible congenital malformations are a major cause of morbidity and mortality among neonates in our unit. To help reduce the morbidity and mortality associated with malformations, awareness-raising, early detection, prevention and improved medical care for affected neonates are needed. This is all the more true in countries where medical resources may be limited and surveillance systems need to be put in place.

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Section: Etiological Factorscontrasting

confidence: 66%

Visible Congenital Malformations in Ouagadougou (Burkina Faso)

Nagalo,

Konaté,

Douamba

et al. 2023

AJPR

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“…Moreover, neonates of obese pregnant women face a higher risk of pre-and post-term birth complications for example small and large for gestational (SGA/LGA), congenital anomalies [17], and perinatal mortality [3,4,18]. Offspring of these obese women may also experience health complications later in life, for instance, hypertension, diabetes or cardiovascular diseases [19].…”

Section: Introductionmentioning

confidence: 99%

Maternal and Neonatal Outcomes of Post-Bariatric Surgery: A Population-Based Study

Al-Dewik,

Samara,

Mahmah

et al. 2024

Preprint

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Objectives: This study has two main goals. The first step is to assess the incidence, risk factors, and maternal and neonatal outcomes in pregnant women who have undergone Bariatric Surgery (BS). Second, to analyze these effects among pregnant women without a history of BS, these include women who are obese, overweight, and of normal weight (non-exposed groups). Methods: This population-based study was conducted using 12-month retrospective registry data from the PEARL-Peristat Study at the Women's Wellness and Research Center (WWRC) in Qatar. A total of 6,212 parturient women and their respective offspring were examined. Participants were categorized into two groups: those with a history of Bariatric Surgery (post-BS) as the exposed group (N=315), and those without such a history as the non-exposed group (N=5,897). Both univariate and multivariable regression analyses were employed to scrutinize risk factors and outcomes. Results: Qatari, advanced maternal age, parity >1, diabetes, and hypertension were found to be significant risk factors for women with post-BS. Also, women in the post-BS group were found to be more likely to have a cesarean delivery (37.5% vs. 24%, aOR=1.59, CI 1.18-2.14), preterm babies (10% vs. 7%, aOR=1.66, CI 1.06-2.59), and stillbirth (1.6% vs. 0.4%, aOR=4.53, CI 1.33-15.50) compared to the normal weight women group. Moreover, post-BS women had a higher risk of low-birth-weight neonates than obese (15% vs. 8%, aOR= 1.77, CI 1.153-2.73), overweight (15% vs. 7%, aOR=1.63, CI:1.09-2.43), and normal weight (15% vs. 8%, aOR=1.838, CI 1.23-2.75) women. Finally, women in the post-BS group were more likely to have low-birth-weight neonates amongst term babies than obese and overweight women. Conclusion: Pregnancies with post-BS should be considered a high-risk group for certain medical outcomes and should be monitored closely. These findings may guide the future clinical decisions of antenatal and postnatal follow-up for post-BS women.

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“…Congenital anomalies afflict approximately 6% of children worldwide each year, with gastrointestinal malformations being among the most prevalent. 1 2 These malformations often require highly complex surgical procedures and can be life-threatening without access to appropriate surgical care. 2 In Brazil, congenital anomalies represent the second leading cause of disability-adjusted life year (DALY) loss in children under 1 year of age.…”

Section: Introductionmentioning

confidence: 99%

Social determinants of gastrointestinal malformation mortality in Brazil: a national study

Gerk,

Rosendo,

Telles

et al. 2024

World Jnl Ped Surgery

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IntroductionIn Brazil, approximately 5% are born with a congenital disorder, potentially fatal without surgery. This study aims to evaluate the relationship between gastrointestinal congenital malformation (GICM) mortality, health indicators, and socioeconomic factors in Brazil.MethodsGICM admissions (Q39–Q45) between 2012 and 2019 were collected using national databases. Patient demographics, socioeconomic factors, clinical management, outcomes, and the healthcare workforce density were also accounted for. Pediatric Surgical Workforce density and the number of neonatal intensive care units in a region were extracted from national datasets and combined to create a clinical index termed‘NeoSurg’. Socioeconomic variables were combined to create a socioeconomic index termed‘SocEcon’. Simple linear regression was used to investigate if the temporal changes of both indexes were significant. The correlation between mortality and the different indicators in Brazil was evaluated using Pearson’s correlation coefficient.ResultsOver 8 years, Brazil recorded 12804 GICM admissions. The Southeast led with 6147 cases, followed by the Northeast (2660), South (1727), North (1427), and Midwest (843). The North and Northeast reported the highest mortality, lowest NeoSurg, and SocEcon Index rates. Nevertheless, mortality rates declined across regions from 7.7% (2012) to 3.9% (2019), a 51.7% drop. The North and Midwest experienced the most substantial reductions, at 63% and 75%, respectively. Mortality significantly correlated with the indexes in nearly all regions (p<0.05).ConclusionOur study highlights the correlation between social determinants of health and GICM mortality in Brazil, using two novel indexes in the pediatric population. These findings provide an opportunity to rethink and discuss new indicators that could enhance our understanding of our country and could lead to the development of necessary solutions to tackle existing challenges in Brazil and globally.

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Prevalence, predictors, and outcomes of major congenital anomalies: A population-based register study

Cited by 18 publications

References 22 publications

Visible Congenital Malformations in Ouagadougou (Burkina Faso)

Visible Congenital Malformations in Ouagadougou (Burkina Faso)

Maternal and Neonatal Outcomes of Post-Bariatric Surgery: A Population-Based Study

Social determinants of gastrointestinal malformation mortality in Brazil: a national study

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