Prevalence, predictors and outcomes of cardiopulmonary resuscitation in hospitalized adult stem cell transplant recipients in the United States: not just opening the black box but exploring an opportunity to optimize!

Identification and profiling of microRNAs expressed in oral buccal mucosa squamous cell carcinoma of Chinese hamster

“…An ocean of researches depicted that miR-21 is widely high expression in many malignant tumors and plays a crucial regulatory role in their growth and apoptosis 28 . In the early study, Soga D et al .…”

Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21-cyclin E2-Bax/caspase-3 signaling pathway

“…Research has also shown that miR-21 plays an important role in a variety of malignant tumors (including tumors in solid organs and the blood system) (15,16). As the only miRNA overexpressed in almost all malignant solid tumors, it has been regarded as a proto-oncogene.…”

“…Generally, it is upregulated in a variety of tumor tissues and cells, such as glioma, cervical, ovarian, bladder, prostatic, lung, breast, thyroid, esophageal and liver cancer, and bile duct carcinoma, pancreatic, colorectal and gastric cancer, B cell lymphoma, leukemia and multiple myelomas. Owing to its participation in cell differentiation, proliferation and apoptosis (15)(16)(17)(18), it is closely related to genesis and development, as well as infiltration and metastasis (19). Moreover, the overexpression of miR-21 was found to increase cell proliferation, and inhibit apoptosis and caspase-3 activity in RCC A-498 cells.…”