Prevalence, Predictors and Treatment Outcome of Type 2 Diabetes among Newly Diagnosed Sputum Positive Pulmonary Tuberculosis Patients in Western Cameroon

Fonkeng, Leonard Sama

doi:10.23937/2474-3658/1510031

Cited by 8 publications

(14 citation statements)

References 22 publications

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“…In this meta-analysis, nine SSA countries were represented. Three of the studies were from Ethiopia [ 16 , 26 , 28 ]; four from Nigeria [ 19 – 22 ], two from Tanzania [ 9 , 23 ], one each from Guinea-Bissau [ 25 ], Cotonou-Benin [ 30 ], Uganda [ 24 ], Guinea [ 29 ], Madagascar [ 17 ], Kenya [ 18 ], and Cameroon [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…The quality score of each original study ranged from four to eight (see Additional file 1 ). Regarding the sampling techniques used, majority ( n = 15, 93.8%) of the included studies used consecutive sampling technique to select study participants [ 9 , 16 , 17 , 20 , 21 , 23 – 25 , 27 – 30 , 82 ]. Concerning the laboratory methods used to diagnose DM, seven studies used FBG [ 17 , 19 , 21 , 28 – 30 ], four used RBS [ 16 , 24 , 25 , 27 ], one each used OGT [ 23 ], HbA1c [ 18 ], and FBG and OGT [ 9 ], two studies did not report the methods used [ 20 , 82 ].…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the sampling techniques used, majority ( n = 15, 93.8%) of the included studies used consecutive sampling technique to select study participants [ 9 , 16 , 17 , 20 , 21 , 23 – 25 , 27 – 30 , 82 ]. Concerning the laboratory methods used to diagnose DM, seven studies used FBG [ 17 , 19 , 21 , 28 – 30 ], four used RBS [ 16 , 24 , 25 , 27 ], one each used OGT [ 23 ], HbA1c [ 18 ], and FBG and OGT [ 9 ], two studies did not report the methods used [ 20 , 82 ]. Regarding study settings, seven out of sixteen studies conducted in hospitals [ 19 , 23 , 24 , 26 – 29 ] and five in health centers [ 16 , 18 , 20 , 30 , 82 ].…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies

et al. 2019

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BackgroundTuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta-analysis estimates the overall prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa.MethodsFour international databases (PubMed, Google Scholar, Science Direct and Cochrane Library) were systematically searched. We included all observational studies reporting the prevalence of DM among TB patients in Sub-Saharan Africa. All necessary data for this review were extracted using a standardized data extraction format by two authors (CT and AA1). STATA Version 14 statistical software was employed to conduct meta-analysis. The Cochrane Q test statistics and I2 test were used to assess the heterogeneity of the studies. Finally, a random effects meta-analysis model was computed to estimate the pooled prevalence of diabetes mellitus in TB patients. Besides, subgroup analysis was done based on different factors.ResultsIn the meta-analysis, sixteen studies fulfilled the inclusion criteria and were included. The findings of these 16 studies revealed that the pooled prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was 9.0% (95% CI: 6.0, 12.0%). The highest prevalence of diabetes mellitus among tuberculosis patients was found in Nigeria (15%), followed by Tanzania (11%), and then Ethiopia (10%). Besides, the prevalence of diabetes mellitus among HIV infected TB patients was (8.9%) which is slightly higher than HIV uninfected (7.7%) TB patients.ConclusionDiabetes mellitus among tuberculosis patients in Sub-Saharan Africa was significantly high. Moreover, this study found that there was a high prevalence of DM among HIV infected than uninfected TB patients. It is strongly recommended to screen for DM among TB patients and special emphasis should be given for early screening of DM among TB/HIV co-infected patients.Electronic supplementary materialThe online version of this article (10.1186/s12879-019-3892-8) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies

et al. 2019

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“…After dividing the prevalence of latent tuberculosis by age groups, the pubertal age group [age in median(IQR)][14 (12– 15 )] had slightly higher prevalence of latent TB 10 (19.6%) than pre-pubertal age group [Age in Median (IQR)] 8 [ 6 – 9 ] 3 (8.1%) and post-pubertal 29 (15%) age group [Median (IQR)]. The findings in the pubertal age group (median(IQR)][14 (12– 15 )]) were similar to the findings shown by Muro et al and Kidola et al that had the prevalence of latent tuberculosis at 18% and 19.2% respectively [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Latent tuberculosis in children and youth with type 1 diabetes mellitus in Dar es Salaam, Tanzania: a cross section survey

Majaliwa,

Muze,

Godfrey

et al. 2023

BMC Infect Dis

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Background Data for latent tuberculosis in patients with type 1 Diabetes in Africa is limited. We assessed the prevalence of latent tuberculosis in youth and children with type 1 Diabetes in Dar es Salaam –Tanzania. Methods Our cross-sectional study recruited children and youth with T1DM by stage of puberty, glycaemic control, and age at diagnosis from January to December 2021 in Dar es Salaam. Participants were screened for the presence of latent Tuberculosis using the QuantiFERON test. A positive test was considered to have latent TB. Results Of the 281 participants, the mean age was 19 (± 6) years, 51.2% were female, and 80.8% had either a primary or secondary level of education at baseline. The prevalence of latent TB was 14.9% and was slightly higher in females (52.4%) than in males. This difference, however, was insignificant (p > 0.05). On the other hand, the proportion of latent TB was significantly higher in uncontrolled HbA1c levels (76.2%) than in those with controlled HbA1c (23.8%) [p = 0.046]. Duration of diabetes and age at diagnosis did not affect the occurrence of latent Tuberculosis [p > 0.05]. Meanwhile, in the regression model, participants with latent TB were more likely to have uncontrolled HbA1c. [p = 0.045] Conclusions Despite the methodological limitations, this survey highlights the high prevalence of latent TB among children and youth with diabetes; shouting for better control. These results clearly show the need to screen for Tuberculosis in children and youth with diabetes and start them on prevention as per protocol, especially in tuberculosis-endemic areas like Tanzania.

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“…Pada penelitian ini didapatkan angka keberhasilan pengobatan yang tinggi karena dilakukan pemantauan dalam pengobatan pada penelitian ini, untuk melihat perkembangan dari pengobatan dilakukan pemeriksaan dahak pada 2 bulan setelah pengobatan kemudian dilakukan pemantauan gula darah secara rutin untuk meminimalisir kegagalan dalam pengobatan. 25…”

Section: Komorbiditas Tuberkulosis Paru Dan Diabetes Melitusunclassified

Keberhasilan Pengobatan Tuberkulosis Paru dengan Komorbid Diabetes Mellitus Tipe 2

2021

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Tuberkulosis merupakan penyakit infeksi paru dan diabetes mellitus merupakan gangguan metabolisme karena terdapat kelainan pada insulin. Keduanya memiliki hubungan dua arah yang sudah banyak dibuktikan, risiko terjadinya TB pada penderita DM akibat adanya gangguan sistem imun. Pada diabetes imunitas seluler berkurang yang berdampak pada berkurang nya limfosit dan makrofag yang peranan penting dalam pertahanan terhadap kuman Mycobacterium tuberculosis. Pengobatan pada tuberkulosis paru dengan penyakit penyerta diabetes mellitus berpontesi menyebabkan kegagalan dalam pengobatan, oleh karena itu perlu dilakukannya pemantauan dalam pengobatan untuk mencapai sasaran dalam pengobatan, dan perlu diperhatikan ada nya interaksi antara OAT yang mempengaruhi konsentrasi obat antiadiabetik oral agar mendapatkan dosis yang tepat untuk mencapai keberhasilan pengobatan.

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Prevalence, Predictors and Treatment Outcome of Type 2 Diabetes among Newly Diagnosed Sputum Positive Pulmonary Tuberculosis Patients in Western Cameroon

Cited by 8 publications

References 22 publications

Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies

Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies

Latent tuberculosis in children and youth with type 1 diabetes mellitus in Dar es Salaam, Tanzania: a cross section survey

Keberhasilan Pengobatan Tuberkulosis Paru dengan Komorbid Diabetes Mellitus Tipe 2

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