Medical students represent a vulnerable group for primary headache disorders, as they are exposed to various physical and psychological stressors. Methods: We carried an observational, crosssectional study, and collected data during February, 2017 using electronic questionnaires. The international classification of headache disorders, third edition)ICHD-3(beta edition was used to classify headache into 10 types. Results: A total of 623 responses)82.2%(were received out of 758 participants. The one-year headache prevalence was 558)89.6%(. The most common diagnosis among both genders was frequent tension-type headache)TTH()n=173, 31.0%(, followed by probable infrequent TTH)n=114, 20.4%(and probable frequent TTH)n=63, 11.3%(. The greatest proportions of students who reported an impact of their academic level were found among the chronic TTH, migraine without and with aura)n=2, 40.0%; n=14, 34.4%; n=11, 33.3%(. Migraine without aura was more prevalent among females)n=29, 10.5%(than males)n=10, 3.5%(. Selfmedication was common)62.5%-100.0%(. Simple analgesics)67.4%-80.0%(, sleeping)54.3%-80.0%(and caffeine intake)28.3%-60.0%(were the top 3 therapies that were practiced. Conclusion: The prevalence of headache among Umm Al-Qura university)UQU(, Makkah, Kingdom of Saudi Arabia's medical students appears higher than the prevalence among the general population. This may have a significant impact on academic performance and necessitates special attention. We recommend further studies on interventions to reduce the prevalence and impact of this prevalent problem.