Prevalence, Presentation and Outcomes of Silent Hypoxemia in COVID-19

Ribeiro, Amélia Galdino; Mendonca, M I; Sousa, Cláudia S.; Barbosa, Miguel T.; Morais‐Almeida, Mário

doi:10.1177/11795484221082761

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…In a recent 2022 literature review conducted by Ribeiro et al, silent hypoxemia was found to have a highly variable prevalence ranging from 3 to 56.5% according to a review of eight prospective and retrospective single-site and multicenter mixed studies. Clinically, the appearance of the subjects of this study also showed a stable condition during surveillance, but after the observation period, their condition worsened and they eventually died, which is in stark contrast to the clinical appearance [20]. This study was conducted during the third wave of the pandemic which was most feared by far because of the delta variant of the SARS-CoV-2 virus.…”

Section: Discussionmentioning

confidence: 72%

Contributing Factors to Increased Left Ventricular End-Diastolic Volume in COVID-19 ICU Patients in Sanglah Hospital: A Study on Galectin-3

Lolobali

Widnyana

Wulansari

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Coronavirus disease 2019 (COVID-19) is a respiratory disease that has become the largest pandemic and also could put the heart at risk of dysfunction. Galectin-3 is involved in the inflammatory process that continues with remodeling and eventually fibrosis. Using galectin-3 examination, we could predict the possible worsening of heart function and evaluate data on influencing factors for increased left ventricular end-diastolic volume (LVEDV) which could later progress to heart failure. METHODS: This is an observational prospective analytic study in the COVID-19 ICU of Sanglah Hospital, Bali, Indonesia. The study was conducted from June to October 2021. All research subjects had their blood samples taken for galectin-3 levels examination using enzyme-linked immunosorbent assay (ELISA). Subjects were also evaluated for left ventricular end-diastolic volume (LVEDV) with echocardiography, SOFA scores, and troponin I levels. Subjects were treated with COVID-19 standard protocol established by the Ministry of Health. After 72 h post-admission, subjects were re-examined for galectin-3 levels and LVEDV. Data were analyzed using STATA™. RESULTS: A total of 45 research subjects were analyzed. Bivariate analysis of the difference of galectin-3 and LVEDV was shown to be insignificant (r = 0.08), no correlation was found between galectin-3 level and LVEDV on ICU admission (r = 0.191), and no correlation found between galectin-3 level and LVEDV after 72 h of hospitalization (r=0.197). Multivariate analysis also showed that none of the variables, namely, difference of galectin-3 level, age, gender, troponin I, SOFA, and Charlson scores had statistically significant correlation with LVEDV (p < 0.05). CONCLUSION: No significant correlation was found between galectin-3 level and an increase in LVEDV.

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Section: Discussionmentioning

confidence: 72%

Contributing Factors to Increased Left Ventricular End-Diastolic Volume in COVID-19 ICU Patients in Sanglah Hospital: A Study on Galectin-3

Lolobali

Widnyana

Wulansari

et al. 2022

Open Access Maced J Med Sci

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“…Additionally, patients with NRS could develop profound hypoxemia without dyspnoea, called “silent or happy hypoxemia”, which may deteriorate rapidly without warning and has been associated with increased mortality [ 35 ]. However, this association remains controversial [ [36] , [37] , [38] ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Citarella,

Kartsonaki,

Ibáñez-Prada

et al. 2024

Heliyon

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“…In particular, we found a significant increase in the levels of branched-chain, aromatic, and sulfur-containing amino acids in lung tissue from fatal COVID-19 cases. Many of these have been recognized as sepsis and inflammatory markers and are associated with lung injury, a condition that commonly leads to severe refractory hypoxemia and is one of the main causes of mortality in COVID-19 patients ( Dhont et al, 2020 ; Donina, 2022 ; Ribeiro et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

A comparative NMR-based metabolomics study of lung parenchyma of severe COVID-19 patients

Hurtado,

López-Radcenco,

Izquierdo-García

et al. 2023

Front. Mol. Biosci.

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COVID-19 was the most significant infectious-agent-related cause of death in the 2020-2021 period. On average, over 60% of those admitted to ICU facilities with this disease died across the globe. In severe cases, COVID-19 leads to respiratory and systemic compromise, including pneumonia-like symptoms, acute respiratory distress syndrome, and multiorgan failure. While the upper respiratory tract and lungs are the principal sites of infection and injury, most studies on the metabolic signatures in COVID-19 patients have been carried out on serum and plasma samples. In this report we attempt to characterize the metabolome of lung parenchyma extracts from fatal COVID-19 cases and compare them with that from other respiratory diseases. Our findings indicate that the metabolomic profiles from fatal COVID-19 and non-COVID-19 cases are markedly different, with the former being the result of increased lactate and amino acid metabolism, altered energy pathways, oxidative stress, and inflammatory response. Overall, these findings provide additional insights into the pathophysiology of COVID-19 that could lead to the development of targeted therapies for the treatment of severe cases of the disease, and further highlight the potential of metabolomic approaches in COVID-19 research.

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Prevalence, Presentation and Outcomes of Silent Hypoxemia in COVID-19

Cited by 4 publications

References 30 publications

Contributing Factors to Increased Left Ventricular End-Diastolic Volume in COVID-19 ICU Patients in Sanglah Hospital: A Study on Galectin-3

Contributing Factors to Increased Left Ventricular End-Diastolic Volume in COVID-19 ICU Patients in Sanglah Hospital: A Study on Galectin-3

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

A comparative NMR-based metabolomics study of lung parenchyma of severe COVID-19 patients

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