Prevalence profile of burning mouth syndrome in a sample of Egyptian population: A cross-sectional clinical based study

Ghalwash, Dalia; Abou-Bakr, Asmaa; Ammar, Ahmed; Hamdy, Ahmed; El-Gawish, Ayman

doi:10.37349/emed.2024.00244

Exploration of Medicine

2024

DOI: 10.37349/emed.2024.00244

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Prevalence profile of burning mouth syndrome in a sample of Egyptian population: A cross-sectional clinical based study

Dalia Ghalwash,

Asmaa Abou-Bakr,

Ahmed Ammar

et al.

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2024

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Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population

Ghalwash,

Ammar,

Abou-Bakr

et al. 2024

Future Science OA

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Purpose The present study evaluated the sensitivity and specificity of important proteomic salivary biomarkers; IL-6, IL-8, and sCD44 in the early detection of oral cancer, and any possible associations with risk factors of oral cancer in an Egyptian population. Methods The present investigation was conducted on 100 individuals; 25 healthy controls, 25 patients having oral potentially malignant disorders (OPMDs) with dysplasia; 25 patients having OPMDs without dysplasia, and 25 oral cancer patients. Demographic data modified gingival index, oral hygiene level, and salivary levels of the biomarkers were assessed. Results Salivary levels of IL-6, IL-8, and sCD44 progressively increased with increased disease severity. Salivary IL-8 and IL-6 levels possess a discriminating potential from normal tissue through different degrees of dysplasia to oral cancer, sCD44 levels had a discriminating power between normal and dysplastic tissues with high sensitivity and specificity. A positive correlation was found between the three biomarkers and the grade of oral squamous cell carcinoma (OSCC) and with different risk factors. Conclusion This is the first study that evaluated multiple salivary proteomic biomarkers in the Egyptian population, and the results validate the ability of IL-6, IL-8, and sCD44 to be used as sensitive diagnostic and prognostic biomarkers for screening and early detection of oral cancer.

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Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population

Ghalwash,

Ammar,

Abou-Bakr

et al. 2024

Future Science OA

View full text Add to dashboard Cite

show abstract

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Prevalence profile of burning mouth syndrome in a sample of Egyptian population: A cross-sectional clinical based study

Cited by 1 publication

References 38 publications

Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population

Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population

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