Prevalence Rates of Personality Disorder and Its Association With Methamphetamine Dependence in Compulsory Treatment Facilities in China

Zhang, Chenxi; Luo, Tao; Liu, Liang; Dong, Huixi; Hao, Wei

doi:10.3389/fpsyt.2018.00698

Cited by 13 publications

(15 citation statements)

References 73 publications

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“…Another study reported an association between psychiatric disorders caused by chronic and heavy MA abuse and ASPD 16 . In similar research in China, the occurrence rate of ASPD in MA dependent was 75.5%, significantly higher than the nondependent group (59.9%) 17 . Taken together, these results show a high prevalence rate of ASPD in MA patients.…”

Section: Introductionsupporting

confidence: 54%

“…16 In similar research in China, the occurrence rate of ASPD in MA dependent was 75.5%, significantly higher than the nondependent group (59.9%). 17 Taken together, these results show a high prevalence rate of ASPD in MA patients.…”

Section: Introductionmentioning

confidence: 52%

“…34 However, our prevalence of ASPD in MA patients was significantly lower than 71.4% in another study in China, which was diagnosed by the Structured Clinical Interview for DSM-IV (SCID). 17 It appears that there is a remarkable difference in the prevalence rate of ASPD in MA patients across studies, which may be due to the different diagnostic criteria used in these studies. Taken together, the rate of ASPD in MA patients is significantly higher than that in the general population.…”

Section: Prevalence Demographic and Clinical Characteristics Of Aspd ...mentioning

confidence: 89%

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Prevalence, demographics, and clinical correlates of antisocial personality disorder in Chinese methamphetamine patients

Tian

Fan³

et al. 2022

American J Addict

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Background and Objectives: Antisocial personality disorder (ASPD) is very common among methamphetamine (MA) patients, but very few studies have been conducted in China. This study aimed to investigate the prevalence and clinical correlates of ASPD among Chinese MA patients. Methods: We recruited 627 MA patients and collected demographic and MA use data through one-on-one semi-structured interviews. ASPD was measured by the Mini International Neuropsychiatric Interview (M.I.N.I.). The Desires for Drug Questionnaire (DDQ) and visual analog scale (VAS) were used to assess drug cravings.Results: The prevalence rate of ASPD among MA patients was 27.59% (173/627).Patients with ASPD had greater age at the first onset, duration of MA use, length of abstinence, VAS, DDQ desire and intention, negative reinforcement, and total DDQ scores than patients without ASPD. Stepwise binary logistic regression analysis revealed that age, age at the first onset, length of abstinence, and DDQ-negative reinforcement were independently associated with ASPD in MA patients.Discussion and Conclusions: Our findings suggest that the prevalence of ASPD is high among Chinese MA patients. Furthermore, some demographic and clinical variables are associated with ASPD in MA patients.Scientific Significance: We focused our study on the clinical profile of ASPD and the reasons for its high prevalence in Chinese methamphetamine patients. We identified several demographic and clinical variables as correlates of the occurrence of ASPD in methamphetamine patients, which provides evidence for ASPD comorbidity in methamphetamine patients.

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Section: Introductionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 52%

Section: Prevalence Demographic and Clinical Characteristics Of Aspd ...mentioning

confidence: 89%

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Prevalence, demographics, and clinical correlates of antisocial personality disorder in Chinese methamphetamine patients

Tian

Fan³

et al. 2022

American J Addict

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“…Approximately one in five people with bipolar disorder is also diagnosed with borderline or emotionally unstable PD [13], affective and anxiety disorders are strongly associated with schizotypal PD [14], and the prevalence rate of PDs in individuals at high risk for psychosis has been found to be as high as 39% [15]. There is also a well-known relationship between PDs and substance use disorder (SUD) [16][17][18][19][20][21][22][23][24]. A clinical study from Denmark found comorbid SUD in 39% of patients with PDs [16], and a systematic review from 2000 estimates that 38-57% of patients with borderline PD have at least one SUD diagnosis [24].…”

Section: Introductionmentioning

confidence: 99%

Total and cause-specific mortality in patients with personality disorders: the association between comorbid severe mental illness and substance use disorders

Høye

Jacobsen

Bramness

et al. 2021

Soc Psychiatry Psychiatr Epidemiol

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Purpose To investigate the mortality in both in- and outpatients with personality disorders (PD), and to explore the association between mortality and comorbid substance use disorder (SUD) or severe mental illness (SMI). Methods All residents admitted to Norwegian in- and outpatient specialist health care services during 2009–2015 with a PD diagnosis were included. Standardized mortality ratios (SMRs) with 95% confidence intervals (CI) were estimated in patients with PD only and in patients with PD and comorbid SMI or SUD. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) with 95% CIs in patients with PD and comorbid SMI or SUD compared to patients with PD only. Results Mortality was increased in both in- and outpatients with PD. The overall SMR was 3.8 (95% CI 3.6–4.0). The highest SMR was estimated for unnatural causes of death (11.0, 95% CI 10.0–12.0), but increased also for natural causes of death (2.2, 95% CI 2.0–2.5). Comorbidity was associated with higher SMRs, particularly due to poisoning and suicide. Patients with comorbid PD & SUD had almost four times higher all-cause mortality HR than patients with PD only; young women had the highest HR. Conclusion The SMR was high in both in- and outpatients with PD, and particularly high in patients with comorbid PD & SUD. Young female patients with PD & SUD were at highest risk. The higher mortality in patients with PD cannot, however, fully be accounted for by comorbidity.

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“…Two hundred and seven male MA abusers, with an MA abuse frequency of ≥10 times and an MA abuse duration of ≥1 year from 577 volunteer participants of Xinkaipu Compulsory Rehabilitation Institute (Changsha, Hunan) and White Mud Lake Compulsory Rehabilitation Institute (Xiangyin, Hunan), underwent a Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I/P) from March 2013 to January 2014. Compulsory rehabilitation is the primary form of treatment for illegal drug dependence (61.6% drug users received compulsory treatment by 2012) in China (21). The residential MA users were admitted in the treatment facilities after confirmed MA use by urine or hair test.…”

Section: Participantsmentioning

confidence: 99%

Genome-Wide DNA Methylation Analysis in Male Methamphetamine Users With Different Addiction Qualities

Liu

Luo²,

Dong³

et al. 2020

Front. Psychiatry

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This paper aimed to explore the genome-wide DNA methylation status of methamphetamine (MA) abusers with different qualities to addiction and to identify differentially methylated candidate genes. A total of 207 male MA abusers with an MA abuse frequency of ≥10 times and an MA abuse duration of ≥1 year were assigned to the high MA addiction quality group (HMAQ group; 168 subjects who met the diagnostic criteria for MA dependence according to the DSM-IV) or to the low MA addictive quality group (LMAQ group; 39 subjects who did not meet the criteria for MA dependence). In addition 105 healthy controls were recruited. Eight HMAQ subjects, eight LMAQ subjects, and eight healthy controls underwent genome-wide DNA methylation scans with an Infinium Human Methylation 450 array (Illumina). The differentially methylated region (DMR) data were entered into pathway analysis, and the differentially methylated position (DMP) data were screened for candidate genes and verified by MethyLight qPCR with all samples. Seven specific pathways with an abnormal methylation status were identified, including the circadian entrainment, cholinergic synapse, glutamatergic synapse, retrograde endocannabinoid signaling, GABAergic synapse, morphine addiction and PI3K-Akt signaling pathways. SLC1A6, BHLHB9, LYNX1, CAV2, and PCSK9 showed differences in their methylation levels in the three groups. Only the number of methylated copies of CAV2 was significantly higher in the LMAQ group than in the HMAQ group. Our findings suggest that the circadian entrainment pathway and the caveolin-2 gene may play key roles in MA addiction quality. Further studies on their functions and mechanisms will help us to better understand the pathogenesis of MA addiction and to explore new targets for drug intervention.

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Prevalence Rates of Personality Disorder and Its Association With Methamphetamine Dependence in Compulsory Treatment Facilities in China

Cited by 13 publications

References 73 publications

Prevalence, demographics, and clinical correlates of antisocial personality disorder in Chinese methamphetamine patients

Prevalence, demographics, and clinical correlates of antisocial personality disorder in Chinese methamphetamine patients

Total and cause-specific mortality in patients with personality disorders: the association between comorbid severe mental illness and substance use disorders

Genome-Wide DNA Methylation Analysis in Male Methamphetamine Users With Different Addiction Qualities

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