Prevalence, risk factors and clinical correlates of glucose disturbances in a large sample of Han Chinese patients with first-episode drug-naïve major depressive disorder

Chen, Shi Wang; Wu, Yan; Shen, Li; Li, Jie; Lang, Xiao E; Zhang, Xiangyang

doi:10.1007/s00406-023-01581-2

Cited by 3 publications

(2 citation statements)

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“…For example, previous studies have found that women report signi cantly more COVID-19 distress than men [35] , and large-scale epidemiological studies have found a higher prevalence of anxiety in female than male MDD patients [14,36]. Furthermore, in a sample of Chinese patients with rstepisode depression, women had signi cantly more comorbid anxiety and sleep problems than men [37]. The differences may be due to different sampling frames or cultural backgrounds.…”

Section: Discussionmentioning

confidence: 98%

Sex Differences in the Prevalence of Suicide Attempts and Associated Risk Factors among Young, First-Episode and Drug-Naive Major Depressive Disorder Patients with Anxiety Symptoms

Jiang,

Lang,

Wang

et al. 2023

Preprint

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Background Suicide attempts and anxiety are common commodities in patients with major depressive disorder (MDD), and suicide attempts are often associated with anxiety symptoms. Studies have found gender differences in several aspects of MDD; however, gender differences in suicide attempts in young first-episode and drug-naive (FEDN) MDD patients with anxiety remain unknown. This study aimed to investigate potential gender differences in the prevalence of suicide attempts and associated risk factors among young FEDN MDD patients with anxiety in a Chinese Han population. Method A cross-sectional study was conducted on 1289 young patients with FEDN MDD. Demographics, clinical characteristics, and biochemical parameters of patients were collected. Results Suicide attempters accounted for 23.80% and 26.12% of male and female FEDN MDD patients with anxiety, respectively, with no significant sex differences. Binary logistic regression analyses showed that anxiety, clinical global impression severity, and thyroid peroxidase antibody significantly predicted suicide attempts in both male and female FEDN MDD patients with anxiety, while body mass index significantly predicted suicide attempts only in males, and psychotic symptoms predicted suicide attempts only in females. Conclusions Our study is the first large survey on the sex differences in the prevalence of suicide attempts and associated risk factors among young FEDN MDD patients with anxiety in a Chinese Han population.Our findings suggest that risk factors associated with suicide attempts differ by gender in young FEND MDD patients with anxiety, despite of a similar rate of suicide attempts in female and male patients.

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Section: Discussionmentioning

confidence: 98%

Sex Differences in the Prevalence of Suicide Attempts and Associated Risk Factors among Young, First-Episode and Drug-Naive Major Depressive Disorder Patients with Anxiety Symptoms

Jiang,

Lang,

Wang

et al. 2023

Preprint

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“…[9] It is a state of abnormal glucose tests but not up to the diagnostic criteria for diabetes, including impaired fasting glucose (IFG) (fasting plasma glucose 5.6-6.9 mmol/L), impaired glucose tolerance (IGT; 2 h glucose 7.8-11.0 mmol/L) during a 75 g oral glucose tolerance test (OGTT), and hemoglobin A1c (HbA1c) in the range of 5.7-6.4%. [10,11] Based on the previous de nition, [12][13][14][15] this study refers to NDR and prediabetes collectively as abnormal glucose metabolism (AGM), in contrast with NGM.…”

Section: Introductionmentioning

confidence: 99%

Reduced macular thickness and vascular density in abnormal glucose metabolism patients: A meta-analysis of optical coherence tomography (OCT) and OCT angiography studies

Fu,

Ren,

Chen

et al. 2024

Chinese Medical Journal

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Background: Alterations in macular thickness and vascular density before clinically visible diabetic retinopathy (DR) remain inconclusive. This study aimed to determine whether retinal manifestations in abnormal glucose metabolism (AGM) patients differ from those in the healthy individuals. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 Statement was followed as our guideline for this meta-analysis. PubMed, Embase, and Web of Science were searched between 2000 and 2021. The eligibility criteria were AGM patients without DR. Primary and secondary outcomes measured by optical coherence tomography (OCT) and OCT angiography (OCTA) were analyzed and expressed as standardized mean differences (SMDs) with 95% confidence intervals (CIs). A random-effects model was used in the data synthesis. The meta-analysis was conducted using Stata (version 13.1). Results: A total of 86 observational studies involving 13,773 participants and 15,416 eyes were included. OCT revealed that compared to healthy controls, the total macular thickness of AGM patients was thinner, including the thickness of fovea (–0.24, 95% CI [–0.39, –0.08]; P = 0.002, I 2 = 87.7%), all regions of parafovea (–0.32, 95% CI [–0.54, –0.11]; P = 0.003; I 2 = 71.7%) and the four quadrants of perifovea; the thickness of peripapillary retinal nerve fiber layer (pRNFL), macular retinal nerve fiber layer (mRNFL), and ganglion cell layer (GCL) also decreased. OCTA indicated that the superficial and deep vascular density decreased, the foveal avascular zone (FAZ) area enlarged, and the acircularity index (AI) reduced in AGM individuals. Conclusions: Retinal thinning and microvascular lesions have occurred before the advent of clinically detectable DR; OCT and OCTA may have the potential to detect these preclinical changes. Registration: PROSPERO; http://www.crd.york.ac.uk/prospero/; No. CRD42021269885.

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From pathogenesis of stress-related mental disorders to treatment: beyond the brain

Liu,

2024

Eur Arch Psychiatry Clin Neurosci

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Prevalence, risk factors and clinical correlates of glucose disturbances in a large sample of Han Chinese patients with first-episode drug-naïve major depressive disorder

Cited by 3 publications

References 44 publications

Sex Differences in the Prevalence of Suicide Attempts and Associated Risk Factors among Young, First-Episode and Drug-Naive Major Depressive Disorder Patients with Anxiety Symptoms

Sex Differences in the Prevalence of Suicide Attempts and Associated Risk Factors among Young, First-Episode and Drug-Naive Major Depressive Disorder Patients with Anxiety Symptoms

Reduced macular thickness and vascular density in abnormal glucose metabolism patients: A meta-analysis of optical coherence tomography (OCT) and OCT angiography studies

From pathogenesis of stress-related mental disorders to treatment: beyond the brain

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