Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study

Kiguen, Ana Ximena; Marramá, Marcela; Ruiz, Susana; Estofán, Patricia; Venezuela, Raúl Fernando; Mosmann, Jessica Paola; Monetti, Marina; Rivero, Virginia; Cuffini, Cecilia

doi:10.1371/journal.pone.0217245

Cited by 18 publications

(14 citation statements)

References 27 publications

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“…These results are in concordance with a study from India, which detected more prevalence of C.trachomatis in patients with abnormal cytology (31.5%) in comparison with normal cytology (5.8%) in women with complaints of vaginal discharge attending STI clinic in a tertiary care hospital in New Delhi [ 30 ]. On the other hand, other studies showed different results, such as local studies: Jordá, detected 8.5% C.trachomatis prevalence in symptomatic (vaginal discharge, pruritus, pelvis pain) and asymptomatic women with a request for a vaginal exudate study [ 31 ] and Kiguen, 6.9% in pregnant women, older than 14 years having 35 weeks of gestation [ 32 ], all results lower than our prevalence detected. Other studies, conducted by Ji, detected similar prevalence of C.trachomatis in women with normal and abnormal cytology, 7.1 and 7.2%, respectively, in China [ 5 ] and Costa Lira, detected to genital C.trachomatis in 9.02% in women who used public health services with abnormal cytology [ 25 ].…”

Section: Discussioncontrasting

confidence: 93%

Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology

et al. 2021

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Background HPV and C.trachomatis are the most prevalent, viral and bacterial STI worldwide. Both commonly have an asymptomatic development and can evolve into a persistent infection which, added to coinfections, may be important cofactors for the oncogenic transformation. Objective Evaluate the prevalence of oral and genital HPV and C.trachomatis infection in women with normal and abnormal cervical cytology. Study design The cross-sectional study included 200 swabs, 100 oral and 100 cervical from 50 women with normal and 50 with abnormal cervical cytology. HPV and C.trachomatis infections were detected using PCR with specific primers. Results HPV DNA was detected in 27% (n = 27/100) of women with normal and abnormal cytology. Out of 100 genital samples we detected HPV DNA in 18% (n = 18/100) and 14% (n = 14/100) out of 100 oral samples. HPV genotypes detected were genotype 6 of low-risk and 16, 31, 52, 58 and 16–31 coinfection of high-risk. C.trachomatis DNA was detected in 49% (n = 49/100) of patients. Out of 100 genital samples we detected C.trachomatis in 35% (n = 35/100) and 31% (n = 31) out of 100 oral samples. There is statistically significant (p < 0.05) between cytology and HPV and C.trachomatis infection but there is no statistically significant between cytology and the other characteristics. Conclusions Since the histology of oral mucosa resembles that of the uterine cervix, we can anticipate the presence of HPV and other STI which are detected in different lesions of genital areas and the oral mucosa. Therefore, is important C.trachomatis detection and specific treatment in asymptomatic women because this infection may increase the risk of HPV persistence and coinfection induces a pro-inflammatory environment that may promote the carcinogenesis.

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Section: Discussioncontrasting

confidence: 93%

Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology

et al. 2021

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“…These results are in concordance with a study from India, which detected more prevalence of C.trachomatis in patients with abnormal cytology (31.5%) in comparison with normal cytology (5.8%) [28]. On the other hand, other studies showed different results, such as local studies: Jordá, detected 8.5% C.trachomatis prevalence in symptomatic and asymptomatic women [29] and Kiguen, 6.9% in pregnant women [30], all results lower than our prevalence detected. Other studies, conducted by Ji, detected similar prevalence of C.trachomatis in women with normal and abnormal cytology, 7.1% and 7.2%, respectively [5] and Costa Lira, detected to genital C.trachomatis in 9.02% [24].…”

Section: Discussionsupporting

confidence: 90%

Human Papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology

Mosmann

Zayas

Kiguen

et al. 2021

Preprint

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Background. STI such as HPV and C.trachomatis are important to public health, because of the high risk of asymptomatic genital or oral infections could lead to complications and coinfections may be an important cofactor for the oncogenic transformation.Objective. Evaluate the prevalence of oral and genital HPV and C.trachomatis infection in women with normal and abnormal cervical cytology.Study design. The cross-sectional study included 200 oral and cervical swabs from 50 women with normal and 50 with abnormal cervical cytology. HPV and C.trachomatis infections were detected using PCR with specific primers. Results. HPV DNA was detected in 27% of women with normal and abnormal cytology. Out of 27 we detected HPV DNA in 18% of genital samples and 14% of oral samples. HPV genotypes detected were genotype 6 of low-risk and 16, 31, 52, 58 and 16-31 coinfection of high-risk. C.trachomatis DNA was detected in 49% of patients, out of 49 we detected C.trachomatis in 35% of genital samples and 31% of oral samples. There is statistically significant (p<0.05) between cytology and HPV and C.trachomatis infection but there is no statistically significant between cytology and the other characteristics.Conclusions. The morphological similarity between oropharyngeal and genital epithelia would allowed us to infer that the infection in one of this mucosa could occur in the other. Therefore, is important C.trachomatis detection and specific treatment in asymptomatic women because it is known that may increase the risk of HPV persistence and coinfection induces a pro-inflammatory environment that may promote the carcinogenesis. This study highlight the importance of identified possible cofactors for oncogenesis.

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“…Chlamydia trachomatis (CT) causes the most prevalent bacterial sexual transmitted infection (STI) in the world [1]. Based on the 2018 global STI surveillance from World Health Organization (WHO), global estimation of new CT cases in 2016 was 127 million [2].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis

Huai

Chu

et al. 2020

BMC Infect Dis

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Background: Estimating prevalence of Chlamydia trachomatis (CT) worldwide is necessary in designing control programs and allocating health resources. We performed a meta-analysis to calculate the prevalence of CT in the general population. Methods: The Pubmed and Embase databases were searched for eligible population-based studies from its inception through June 5, 2019. Q test and I 2 statistic were used to calculate the heterogeneity between studies. Random effects models were used to pool the prevalence of CT. Meta regression was performed to explore the possible sources of heterogeneity. Publication bias was evaluated using a funnel plot and "trim and fill" method. Results: Twenty nine studies that reported prevalence of CT infection from 24 countries were identified, including a total population of 89,886 persons. The pooled prevalence of CT among the general population was 2.9% (95% CI, 2.4-3.5%), and females had a higher CT prevalence (3.1, 95% CI, 2.5-3.8%) than males (2.6, 95% CI, 2.0-3.2%) (χ 2 = 10.38, P < 0.01). Prevalence of CT was highest in region of America (4.5, 95% CI, 3.1-5.9%), especially in Latin America (6.7, 95% CI, 5.0-8.4%), followed by females in region of Africa (3.8, 95% CI, 0.7-6.9%), while SouthEast Asia had a lowest CT prevalence 0.8% (95% CI, 0.3-1.3%). Conclusions: This study provided the updated prevalence of CT among general population worldwide. General population from Latin America, especially females, and women in Africa should be given priority by WHO when design and delivery CT control programs.

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Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study

Cited by 18 publications

References 27 publications

Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology

Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology

Human Papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology

Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis

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