Prevalence, risk factors and outcomes of neonatal hypothermia at admission at a tertiary neonatal unit, Kigali, Rwanda – a cross-sectional study

Urubuto, Fedine; Agaba, Faustine; Choi, Jaeseok; Dusabimana, Raban; Teteli, Raissa; Kumwami, Muzungu; Conard, Craig; O’Callahan, Cliff; Cartledge, Peter

doi:10.1080/14767058.2019.1671334

Cited by 10 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, it inhibits the activity of various factors such as IX (2), VII (3), X (4), and VIIa/tissue factor complex (5) and II (6). Finally, it inhibits the primary process of fibrinogen synthesis (7). PF3: platelet factor 3.…”

Section: Figurementioning

confidence: 99%

“…6 The prevalence of hypothermia in moderate to late preterms (32 to <36 + 6 weeks) is 29.1%, which is significantly higher than that in term infants (16.3%). 7 According to the World Health Organization classification, hypothermia is defined as a body temperature below the reference range (36.5°C-37.5°C) and is subclassified into 3 grades: mild (36.0°C-36.5°C); moderate (32.0°C-35.9°C); and severe (<32.0°C). 8 A crosssectional study from Rwanda in Africa reported that of the 1021 eligible neonates, 205 neonates (73.2%) had mild hypothermia, 74 (26.4%) had moderate hypothermia, and only one (0.3%) had severe hypothermia.…”

mentioning

confidence: 99%

“…8 A crosssectional study from Rwanda in Africa reported that of the 1021 eligible neonates, 205 neonates (73.2%) had mild hypothermia, 74 (26.4%) had moderate hypothermia, and only one (0.3%) had severe hypothermia. 7 Although hypothermia is common in neonates, particularly preterm infants, profound hypothermia is very rare, even in preterm infants. 9,10 Hypothermia increases the risk for neonatal mortality and morbidity in both full-term and preterm infants.…”

mentioning

confidence: 99%

“…9,10 Hypothermia increases the risk for neonatal mortality and morbidity in both full-term and preterm infants. 7 Neonatal hypothermia can also be prone to many complications, including metabolic disturbances, coagulopathy, and infection, 11 whereas therapeutic hypothermia that is evidence-based treatment of hypoxic ischemic encephalopathy (HIE) can also be prone to coagulopathy, as well as leukopenia. 12,13 However, profound hypothermia in preterm infants and its complications are rarely reported in the literature.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Profound Hypothermia Concomitant With Severe Coagulation Dysfunction and Leukopenia in a Preterm Infant

Tao

Chen

et al. 2022

Advances in Neonatal Care

View full text Add to dashboard Cite

Background: Neonatal hypothermia is common around the world; however, profound hypothermia is a very rare-but life-threatening-event. Clinical Findings: This was a very rare case involving a 15-day old preterm infant diagnosed with profound hypothermia (rectal temperature, 27°C) concomitant with severe coagulation dysfunction and leukopenia on admission. Primary Diagnosis: Profound hypothermia together with severe coagulopathy, leukopenia, late-onset sepsis, and pneumonia. Interventions:The patient was rewarmed slowly, with a rectal temperature rising at a rate of 0.5°C/h < R < 1°C/h. Vital signs were closely monitored. Coagulation factors were supplemented by intravenous infusion of fresh frozen plasma. Supportive treatment with intravenous infusion of immunoglobulin was provided, and antibiotics were used empirically. Nil per os and intravenous rehydration were also implemented. Outcomes: The condition of the preterm infant gradually improved and was successfully discharged. Practice Recommendations: Profound hypothermia is very rare in preterm infants. However, once it occurs, it may be concomitant with severe coagulopathy and leukopenia. Successful management involves slow rewarming, prompt supplementation of coagulation factors, empirical antibiotics, and supportive treatment.

show abstract

Section: Figurementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Profound Hypothermia Concomitant With Severe Coagulation Dysfunction and Leukopenia in a Preterm Infant

Tao

Chen

et al. 2022

Advances in Neonatal Care

View full text Add to dashboard Cite

show abstract

“…It may also play a protective role in the central nervous system of a newborn with perinatal asphyxia [1]. However, prolonged exposure to cold has been associated with many complications, including hypoglycemia [2], respiratory distress [3], bronchopulmonary dysplasia [4], necrotizing enterocolitis (NEC) [5], metabolic acidosis [6], intraventricular hemorrhage (IVH) [3,7], late-onset sepsis [3,8], and even death [9,10].…”

Section: Introductionmentioning

confidence: 99%

Reducing intraventricular hemorrhage following the implementation of a prevention bundle for neonatal hypothermia

Chiu

Chen

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

Introduction In very low birth weight (VLBW) infants, hypothermia immediately following birth is common even in countries rich in medical resources. The purpose of this study is to design a standard prevention bundle that decreases the rate of hypothermia among infants after birth and to investigate efficacy of the bundle and short-term outcomes for VLBW infants. Methods This quality improvement project was conducted from February 2017 to July 2018 on all VLBW preterm infants admitted at a single referral level III neonatal intensive care unit. The infants were classified into the pre-intervention (February to September 2017) and post-intervention (October 2017 to July 2018) groups according to the time periods when they were recruited. During the pre-intervention period, we analyzed the primary causes of hypothermia, developed solutions corresponding to each cause, integrated all solutions into a prevention bundle, and applied the bundle during the post-intervention period. Afterwards, the incidence of neonatal hypothermia and short-term outcomes, such as intraventricular hemorrhage (IVH), acidosis, and shock requiring inotropic agents, in each group were compared. Results A total of 95 VLBW infants were enrolled in the study, including 37 pre-intervention, and 58 post-intervention cases. The incidence of hypothermia in preterm infants decreased significantly upon the implementation of our prevention bundle, both in the delivery room (from 45.9% to 8.6%) and on admission (59.5% to 15.5%). In addition, the short-term outcomes of VLBW infants improved significantly, especially with the decreased incidence of IVH (from 21.6% to 5.2%, P = 0.015). Conclusions Our standardized prevention bundle for preventing hypothermia in VLBW infants is effective and decreased the IVH rate in VLBW infants. We strongly believe that this prevention bundle is a simple, low-cost, replicable, and effective tool that hospitals can adopt to improve VLBW infant outcomes.

show abstract

Embrace versus Cloth Wrap in preventing neonatal hypothermia during transport: a randomized trial

Morgaonkar

Patel

Phatak³

et al. 2020

J Perinatol

View full text Add to dashboard Cite

Prevalence, risk factors and outcomes of neonatal hypothermia at admission at a tertiary neonatal unit, Kigali, Rwanda – a cross-sectional study

Cited by 10 publications

References 21 publications

Profound Hypothermia Concomitant With Severe Coagulation Dysfunction and Leukopenia in a Preterm Infant

Profound Hypothermia Concomitant With Severe Coagulation Dysfunction and Leukopenia in a Preterm Infant

Reducing intraventricular hemorrhage following the implementation of a prevention bundle for neonatal hypothermia

Embrace versus Cloth Wrap in preventing neonatal hypothermia during transport: a randomized trial

Contact Info

Product

Resources

About