Prevalence, sequence type, and quinolone resistance of Neisseria lactamica carried in children younger than 15 years in Shanghai, China

Shen, Yinfang; Chen, Mingliang

doi:10.1016/j.jinf.2019.08.020

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…In the last decade, however, few surveys have reported data on antimicrobial susceptibility of non-pathogenic Neisseria isolates. Two studies reported high minimum inhibitory concentrations (MICs) for macrolides, cephalosporins and fluoroquinolones among N. lactamica isolates from children in Japan and China in 2015 14 , 15 . One study found 93% fluoroquinolone resistance among commensal Neisseria from asymptomatic N. meningitidis carriers in China 7 .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility of commensal Neisseria in a general population and men who have sex with men in Belgium

Laumen

Dijck

Abdellati

et al. 2022

Sci Rep

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Non-pathogenic Neisseria are a reservoir of antimicrobial resistance genes for pathogenic Neisseria meningitidis and Neisseria gonorrhoeae. Men who have sex with men (MSM) are at risk of co-colonization with resistant non-pathogenic and pathogenic Neisseria. We assessed if the antimicrobial susceptibility of non-pathogenic Neisseria among MSM differs from a general population and if antimicrobial exposure impacts susceptibility. We recruited 96 participants at our center in Belgium: 32 employees, 32 MSM who did not use antibiotics in the previous 6 months, and 32 MSM who did. Oropharyngeal Neisseria were cultured and identified with MALDI-TOF–MS. Minimum inhibitory concentrations for azithromycin, ceftriaxone and ciprofloxacin were determined using E-tests® and compared between groups with non-parametric tests. Non-pathogenic Neisseria from employees as well as MSM were remarkably resistant. Those from MSM were significantly less susceptible than employees to azithromycin and ciprofloxacin (p < 0.0001, p < 0.001), but not ceftriaxone (p = 0.3). Susceptibility did not differ significantly according to recent antimicrobial exposure in MSM. Surveilling antimicrobial susceptibility of non-pathogenic Neisseria may be a sensitive way to assess impact of antimicrobial exposure in a population. The high levels of antimicrobial resistance in this survey indicate that novel resistance determinants may be readily available for future transfer from non-pathogenic to pathogenic Neisseria.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility of commensal Neisseria in a general population and men who have sex with men in Belgium

Laumen

Dijck

Abdellati

et al. 2022

Sci Rep

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“…By way of contrast the median prevalence of ciprofloxacin resistance in 2009 was 24% in the Americas and 6% in Africa [7]. In a similar vein, recent studies from China have found that the prevalence of ciprofloxacin resistance to be 100% in commensal Neisseria and 66% in N. meningitidis [8][9][10].…”

Section: Introductionmentioning

confidence: 92%

Positive Association between the Use of Quinolones in Food Animals and the Prevalence of Fluoroquinolone Resistance in E. Coli and K. Pneumoniae, A. Baumanii and P. Aeruginosa: A Global Ecological Analysis

Kenyon¹

2021

Preprint

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BackgroundIt is unclear what underpins the large global variations in the prevalence of fluoroquinolone resistance in gram-negative bacteria. We tested the hypothesis that different intensities in the use of quinolones for food-animals plays a role. MethodsWe used Spearman’s correlation to assess if the country-level prevalence of fluoroquinolone resistance in human infections with Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa was correlated with the use of quinolones for food producing animals. Linear regression was used to assess the relative contributions of country-level quinolone consumption for food-animals and humans on fluoroquinolone resistance in these 4 species. ResultsThe prevalence of fluoroquinolone resistance in each species was positively associated with quinolone use for food-producing animals (E. coli [ρ=0.55; P<0.001], K. pneumoniae [ρ=0.58; P<0.001]; A. baumanii [ρ=0.54; P=0.004]; P. aeruginosa [ρ=0.48; P=0.008]). Linear regression revealed that both quinolone consumption in humans and food animals were independently associated with fluoroquinolone resistance in E. coli and A. baumanii. ConclusionsReducing quinolone use in food-producing animals may help retard the spread of fluoroquinolone resistance in various gram negative bacterial species.

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“…By way of contrast the median prevalence of ciprofloxacin resistance in 2009 was 24% in the Americas and 6% in Africa [7]. In a similar vein, recent studies from China have found the prevalence of ciprofloxacin resistance to be 100% in commensal Neisseria and 66% in N. meningitidis [8][9][10].…”

Section: Introductionmentioning

confidence: 92%

Positive Association between the Use of Quinolones in Food Animals and the Prevalence of Fluoroquinolone Resistance in E. coli and K. pneumoniae, A. baumannii and P. aeruginosa: A Global Ecological Analysis

Kenyon

2021

Antibiotics

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(1) Background: It is unclear what underpins the large global variations in the prevalence of fluoroquinolone resistance in Gram-negative bacteria. We tested the hypothesis that different intensities in the use of quinolones for food-animals play a role. (2) Methods: We used Spearman’s correlation to assess if the country-level prevalence of fluoroquinolone resistance in human infections with Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa was correlated with the use of quinolones for food producing animals. Linear regression was used to assess the relative contributions of country-level quinolone consumption for food-animals and humans on fluoroquinolone resistance in these 4 species. (3) Results: The prevalence of fluoroquinolone resistance in each species was positively associated with quinolone use for food-producing animals (E. coli [ρ = 0.55; p < 0.001], K. pneumoniae [ρ = 0.58; p < 0.001]; A. baumanii [ρ = 0.54; p = 0.004]; P. aeruginosa [ρ = 0.48; p = 0.008]). Linear regression revealed that both quinolone consumption in humans and food animals were independently associated with fluoroquinolone resistance in E. coli and A. baumanii. (4) Conclusions: Besides the prudent use of quinolones in humans, reducing quinolone use in food-producing animals may help retard the spread of fluoroquinolone resistance in various Gram-negative bacterial species.

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Prevalence, sequence type, and quinolone resistance of Neisseria lactamica carried in children younger than 15 years in Shanghai, China

Cited by 12 publications

References 43 publications

Antimicrobial susceptibility of commensal Neisseria in a general population and men who have sex with men in Belgium

Antimicrobial susceptibility of commensal Neisseria in a general population and men who have sex with men in Belgium

Positive Association between the Use of Quinolones in Food Animals and the Prevalence of Fluoroquinolone Resistance in <em>E. Coli</em> and <em>K. Pneumoniae, A. Baumanii</em> and <em>P. Aeruginosa</em>: A Global Ecological Analysis

Positive Association between the Use of Quinolones in Food Animals and the Prevalence of Fluoroquinolone Resistance in E. coli and K. pneumoniae, A. baumannii and P. aeruginosa: A Global Ecological Analysis

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