Prevalence, serotypes, and drug resistance of nontyphoidal Salmonella among paediatric patients in a tertiary hospital in Guangzhou, China, 2014–2016

Liang, Bingshao; Xie, Yanping; He, Shujun; Mai, Jialiang; Huang, Yanmei; Yang, Lu; Zhong, Huamin; Deng, Qiulian; Yao, Shuwen; Long, Yan; Yang, Yiyu; Gong, Sitang; Zhou, Zhenwen

doi:10.1016/j.jiph.2018.10.012

Cited by 31 publications

(33 citation statements)

References 31 publications

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“…The high incidence of Salmonella infection in children was consistent with another study that a recovery rate of 17.2% in children was reported in Shanghai [15]. The high frequency of infections in children could be attributed to the behavior such as frequent contact with their limbs which could be contaminated by faeces, consumption of contaminated food or water, or person-to-person transmission from an asymptomatic caretaker [23]. S. Typhimurium and S. Enteritidis were the most common serovars in children aged below 5 years old which represented 75.4% (104/138) of the isolates, in accordance with other studies [15,17].…”

Section: Discussionsupporting

confidence: 89%

“…The occurrence of multiple drug resistant strains highlighted the importance of antibiotics resistance surveillance. The high level of resistance to the first-line agents: ampicillin, sulphamethoxazole/trimethoprim, and chloramphenicol was also observed in other studies [23]. A similar profile was also found in the isolates from food-producing animals [34], suggesting the careful use of antibiotics in breeding industry was needed.…”

Section: Typhimurium and S Enteritidis A Broad Range Of Uncommon Sesupporting

confidence: 74%

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Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

Shen

Chen²,

Ou³

et al. 2019

Preprint

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Background: Salmonella is one of the main causes of diarrhea which causes substantial disease burden. To determine the prevalence, serotype distribution, and antimicrobial resistance profiles of clinical Salmonella isolates in Shenzhen, a 6-year surveillance study was conducted. Methods: Three sentinel hospitals were chosen and patients who visited the gastroenteritis clinics with acute diarrhea were enrolled. Salmonella isolates from the stool samples were subjected to serotyping, antimicrobial susceptibility testing to 24 antibiotics, and detection of resistance genes. Results: A total of 297 (5.7%) Salmonella isolates were recovered from stool samples from 5,239 patients. Among the 42 serovars identified, serovar Typhimurium was the most common serotype which represented 39.7% of the isolates (118), followed by serovar Enteritidis (71, 23.9%), London (12, 4.0%), 4, 5, 12: i: - (11, 3.7%), and Senftenberg (8, 2.7%). A high frequency of resistance was found in ampicillin (70.6%), piperacillin (64.5%), tetracycline (63.5%), and streptomycin (54.3%). Resistance to ampicillin and tetracycline was observed in 95.3% of S. Typhimurium isolates; and nalidixic acid in 93.1% of S. Enteritidis isolates. Resistance to 5 or more antimicrobial agents was identified in 78.8% of S. Typhimurium and 69.0% of S. Enteritidis isolates. Conclusions: Salmonella is an important cause of acute gastroenteritis and a broad range of serotypes are prevalent in Shenzhen, with Enteritidis and Typhimurium being the most common serovars. The high level of antibiotic resistance is a serious public health concern and ongoing monitoring coupled with rational use of antibiotics are recommended.Background: Salmonella is one of the main causes of diarrhea which causes substantial disease burden. To determine the prevalence, serotype distribution, and antimicrobial resistance profiles of clinical Salmonella isolates in Shenzhen, a 6-year surveillance study was conducted. Methods: Three sentinel hospitals were chosen and patients who visited the gastroenteritis clinics with acute diarrhea were enrolled. Salmonella isolates from the stool samples were subjected to serotyping, antimicrobial susceptibility testing to 24 antibiotics, and detection of resistance genes. Results: A total of 297 (5.7%) Salmonella isolates were recovered from stool samples from 5,239 patients. Among the 42 serovars identified, serovar Typhimurium was the most common serotype which represented 39.7% of the isolates (118), followed by serovar Enteritidis (71, 23.9%), London (12, 4.0%), 4, 5, 12: i: - (11, 3.7%), and Senftenberg (8, 2.7%). A high frequency of resistance was found in ampicillin (70.6%), piperacillin (64.5%), tetracycline (63.5%), and streptomycin (54.3%). Resistance to ampicillin and tetracycline was observed in 95.3% of S. Typhimurium isolates; and nalidixic acid in 93.1% of S. Enteritidis isolates. Resistance to 5 or more antimicrobial agents was identified in 78.8% of S. Typhimurium and 69.0% of S. Enteritidis isolates. Conclusions: Salmonella is an important cause of acute gastroenteritis and a broad range of serotypes are prevalent in Shenzhen, with Enteritidis and Typhimurium being the most common serovars. The high level of antibiotic resistance is a serious public health concern and ongoing monitoring coupled with rational use of antibiotics are recommended.

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Section: Discussionsupporting

confidence: 89%

Section: Typhimurium and S Enteritidis A Broad Range Of Uncommon Sesupporting

confidence: 74%

Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

Shen

Chen²,

Ou³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…The high incidence of Salmonella infection in children was consistent with another study where a recovery rate of 17.2% in children was reported [15]. The high frequency of infections in children could be attributed to the behavior such as frequent contact with contaminated limbs, consumption of contaminated food or water, or close contacts with an asymptomatic caretaker [23]. S. Typhimurium and S. Enteritidis were the most common serovars in children aged below 5 years old, which represented 75.4% (104/138) of the isolates, in accordance with other studies [15,17] [26], Salmonella was commonly isolated from beef, pork, and poultry meat [27,28].…”

Section: Discussionsupporting

confidence: 89%

“…The occurrence of multiple drug resistant strains raised the importance of antibiotics resistance surveillance. The high level of resistance to the first-line agents: ampicillin, sulphamethoxazole/trimethoprim, and chloramphenicol was also observed in other studies [23]. A similar profile was also found in the isolates from food-producing animals [34], suggesting the careful use of antibiotics in breeding industry was necessary.…”

Section: Discussionsupporting

confidence: 76%

“…Salmonella is an important causative microorganism of acute gastroenteritis, which was shown in the detection rate during 2013 and 2018 (4.2%~6.8%). The detection rate was lower compared with our previous study (12.1%) which incorporated PCR method [19], but it was comparable to another study (4.8%) conducted in Guangzhou using conventional assay [23]. A rate of 4.5% was observed in a large laboratory-based surveillance study in Guangdong province during 2009 and 2012, suggesting the continued prevalence in this region [17].…”

Section: Discussionsupporting

confidence: 47%

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Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

Shen

Chen²,

Ou³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background : Salmonella is one of the main causative agents of diarrhea which results in substantial disease burden. To determine the prevalence, serotype distribution, and antimicrobial resistance profiles of clinical Salmonella isolates in Shenzhen, a 6-year surveillance study was conducted. Methods: Three sentinel hospitals were chosen and patients who visited the gastroenteritis clinics with acute diarrhea were enrolled. Salmonella isolates from the stool samples were subjected to serotyping, antimicrobial susceptibility testing to 24 antibiotics, and detection of resistance genes. Results: A total of 297 (5.7%) Salmonella strains were isolated from stool samples from 5,239 patients. Among the 42 serovars identified, serovar Typhimurium was the most common serotype which represented 39.7% of the isolates (118), followed by serovar Enteritidis (71, 23.9%), London (12, 4.0%), 4, 5, 12: i: - (11, 3.7%), and Senftenberg (8, 2.7%). A high frequency of resistance was found in ampicillin (70.6%), piperacillin (64.5%), tetracycline (63.5%), and streptomycin (54.3%). Resistance to ampicillin and tetracycline was observed in 95.3% of S. Typhimurium isolates; and nalidixic acid in 93.1% of S. Enteritidis isolates. Resistance to 5 or more antimicrobial agents was found in 78.8% of S. Typhimurium and 69.0% of S. Enteritidis isolates. Conclusions: Salmonella is an important cause of acute gastroenteritis and a broad range of serotypes are prevalent in Shenzhen, with Enteritidis and Typhimurium being the most common serovars. The high level of antibiotic resistance is of public health significance and ongoing monitoring combined with rational use of antibiotics are recommended.

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A Highly Drug-Resistant Salmonella Enterica Serovar Weltevreden of Human Origin from India and Detection of its Virulence Factors

Kumar,

Kumar

et al. 2024

Indian J Microbiol

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Prevalence, serotypes, and drug resistance of nontyphoidal Salmonella among paediatric patients in a tertiary hospital in Guangzhou, China, 2014–2016

Cited by 31 publications

References 31 publications

Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

A Highly Drug-Resistant Salmonella Enterica Serovar Weltevreden of Human Origin from India and Detection of its Virulence Factors

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