Prevalence study of oral leukoplakia in a selected population of 1000 patients from the Netherlands

Hogewind, W.F.C.; Waal, I. van der

doi:10.1111/j.1600-0528.1988.tb01781.x

Cited by 36 publications

(28 citation statements)

References 23 publications

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“…The susceptible age for leukoplakia lesions ranged from 40 to 70 years in a study from the Netherlands. In most age categories in this study, the number of women was larger than or equal to the number of men in the leukoplakia group (6). The present study showed a small female preponderance and largely affected elderly males, which is similar to the results of several other studies (4,5,7,20).…”

Section: Discussionsupporting

confidence: 81%

“…The major risk factors of oral leukoplakia (OL) are generally believed to correspond to those of oral squamous cell carcinoma (OSCC); tobacco, alcohol, chewing of areca nut and dietary factors (4). Several studies have shown that risk of OL is 4-6 times higher in smokers than in nonsmokers (5,6). It has also been suggested that OL lesions in smokers occur preferentially in particular locations in the oral cavity (7).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Clinical Risk Factors of Oral Leukoplakia in UP Population of India: An Institutional Study

2014

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Leukoplakia is the most common potentially malignant lesion of the oral mucosa. Studies on the risk factors of oral leukoplakia (OL) are relatively scarce. The present study was planned to assess the clinical risk factors of OL in our institution, which represents a sample of the Western UP population, based on the clinical status of OL patients spanning a period of eight years. The clinical and pathological data (age, sex, lesion location and presence/ absence of dysplasia) were analyzed in these patients. Possible relationships between habitual tobacco use and lesion location were explored. The data obtained showed that habitual bidi smoking was prevalent among elderly males, while buccal mucosa was the most affected site by this lesion. Applying the Z-test for double sample proportions, a significant difference was observed for the buccal mucosa, labial mucosa, tongue and habitual smoking (1% level of significance, p<0.01) between the two age groups. A significant difference was observed between habitual tobacco use and various degrees of dysplasia (Fisherʼs exact test=0.00008, p<0.05). The present study underlines the role of habitual tobacco use in the etiology of OL in the Western UP population of India. Rigorous anti-smoking measures need to be taken in this region in order to prevent transformation into oral cancer.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Assessment of Clinical Risk Factors of Oral Leukoplakia in UP Population of India: An Institutional Study

2014

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“…[421] This was, however, much higher than the 0.5% prevalence reported by Martínez Díaz-Canel and García-Pola Vallejo. [17] The relationship of leukoplakia with the tobacco habit is somewhat controversial.…”

Section: Discussionmentioning

confidence: 89%

Prevalence and the relationship of oral mucosal lesions in tobacco users and denture wearers in the North Indian population

Patil

Yadav

Patil

et al. 2013

J Fam Community Med

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Aim:The aim of the present study was to determine the prevalence and the relationship of oral mucosal lesions in tobacco users and denture wearers in a North Indian population.Materials and Methods:The study comprised 3,749 patients attending the Department of Oral Medicine and Radiology, Jodhpur Dental College General Hospital between September 2008 and December 2012, for the treatment of dental problems other than oral mucosal lesions. The ages ranged from 28 years to 83 years, with a mean age of 49.7 years. The results were evaluated using the Pearson Chi-square test, with Yate’s correction and ANOVA tests.Results:A total of 2,318 patients were diagnosed with lesions associated with the use tobacco and the wearing of dentures. The most frequently seen lesion was melanin pigmentation (29.9%) followed by linea alba (22.2%) and frictional keratosis (19.9%). Ulcers (6.1%) were the most common oral lesion seen in patients who wore dentures, followed by hyperplasia (4.8%). A statistically significant relation (P < 0.05) was established between tobacco and melanin pigmentation, frictional keratosis, traumatic ulcerations and leukoplakia. In those who wore dentures a statistically significant relation (P < 0.05) was found between candidiasis, traumatic ulceration and frictional keratosis.Conclusion:The results of the present study indicate that the association of frictional keratosis with tobacco users and wearers of dentures can help in determining the diagnosis and treatment plan for oral cancer. Wearers of dentures should also be recalled for periodic checks at regular intervals and optimum preventive measures implemented.

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“…This paper is the consensus outcome of a European workshop held in 1995. Epidemiology LP is a fairly common mucocutaneous disease. OLP affects from 0.1 to about 4% of individuals, depending on the population sampled (Bruszt, 1962;Bouquot and Gorlin, 86 Grit Rev Oral Biol Med (1998) 86 1986; Axell, 1987;Axell and Rundquist, 1987;Hogewind and Van der Waal, 1988;Axell et al, 1990;Salonen et cil, 1990;Ban6czy andRigo, 1991, Albrecht et al, 1992). OLP generally is a disease of the middle-aged and elderly (Silverman and Griffith, 1974), and the female-to-male ratio is about 2:1 ).…”

Section: Introductionmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

477

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Prevalence study of oral leukoplakia in a selected population of 1000 patients from the Netherlands

Cited by 36 publications

References 23 publications

Assessment of Clinical Risk Factors of Oral Leukoplakia in UP Population of India: An Institutional Study

Assessment of Clinical Risk Factors of Oral Leukoplakia in UP Population of India: An Institutional Study

Prevalence and the relationship of oral mucosal lesions in tobacco users and denture wearers in the North Indian population

Update On Oral Lichen Planus: Etiopathogenesis and Management

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