Prevalence surveys for podoconiosis and other neglected skin diseases: time for an integrated approach

Marks, Michael; Mitjà, Oriol

doi:10.1016/s2214-109x(19)30158-5

Cited by 6 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In light of the extensive screening, the low observed prevalence and highly focal nature of the disease were particularly striking, reinforcing the limited feasibility of stand-alone surveybased approaches for detecting yaws. Surveys and case-finding activities for yaws should instead be considered when integrated alongside those for other skin NTDs to maximize efficiency (12,27). Our findings also support the use of larger implementation units for MDA at the county level, equivalent to the WHO definition of districts, following confirmation of an active yaws case, given the evident difficulty in excluding occurrence within smaller implementation units.…”

Section: Reidentification Of Yaws Liberiasupporting

confidence: 59%

Epidemiologic and Genomic Reidentification of Yaws, Liberia

Timothy¹,

Beale²,

Rogers³

et al. 2021

Emerg. Infect. Dis.

Self Cite

View full text Add to dashboard Cite

We confirmed endemicity and autochthonous transmission of yaws in Liberia after a population-based, community-led burden estimation (56,825 participants). Serologically confirmed yaws was rare and focal at population level (24 cases; 2.6 [95% CI 1.4–3.9] cases/10,000 population) with similar clinical epidemiology to other endemic countries in West Africa. Unsupervised classification of spatially referenced case finding data indicated that yaws was more likely to occur in hard-to-reach communities; healthcare-seeking was low among communities, and clinical awareness of yaws was low among healthcare workers. We recovered whole bacterial genomes from 12 cases and describe a monophyletic clade of Treponema pallidum subspecies pertenue , phylogenetically distinct from known TPE lineages, including those affecting neighboring nonhuman primate populations (Taï Forest, Côte d’Ivoire). Yaws is endemic in Liberia but exhibits low focal population prevalence with evidence of a historical genetic bottleneck and subsequent local expansion. Reporting gaps appear attributable to challenging epidemiology and low disease awareness.

show abstract

Section: Reidentification Of Yaws Liberiasupporting

confidence: 59%

Epidemiologic and Genomic Reidentification of Yaws, Liberia

Timothy¹,

Beale²,

Rogers³

et al. 2021

Emerg. Infect. Dis.

Self Cite

View full text Add to dashboard Cite

show abstract

“… Environmental suitability for lymphatic filariasis according to the predictive map published by Cano et al (2014) [ 56 ]. …”

Section: Resultsmentioning

confidence: 99%

“…Mapping podoconiosis is an important prerequisite for the initiation of data-driven national control programmes [56]. Surveying all districts in suspected endemic countries will be resource intensive and will take time.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Predicting the environmental suitability and population at risk of podoconiosis in Africa

et al. 2020

View full text Add to dashboard Cite

Podoconiosis is a type of tropical lymphedema that causes massive swelling of the lower limbs. The disease is associated with both economic insecurity, due to long-term morbidityrelated loss of productivity, and intense social stigma. The geographical distribution and burden of podoconiosis in Africa are uncertain. We applied statistical modelling to the most comprehensive database compiled to date to predict the environmental suitability of podoconiosis in the African continent. By combining climate and environmental data and overlaying population figures, we predicted the environmental suitability and human population at risk of podoconiosis in Africa. Environmental suitability for podoconiosis was predicted in 29 African countries. In the year 2020, the total population in areas suitable for podoconiosis is estimated at 114.5 million people, (95% uncertainty interval: 109.4-123.9) with 16.9 million in areas suitable for both lymphatic filariasis and podoconiosis. Of the total 5,712 implementation units (typically second administrative-level units, such as districts) defined by the World Health Organization in Africa, 1,655 (29.0%) were found to be environmentally suitable for podoconiosis. The majority of implementation units with high environmental suitability are located in Angola (80, 4.8%), Cameroon (170, 10.3%), the DRC (244, 14.7%), Ethiopia (495, 29.9%), Kenya (217, 13.1%), Uganda (116, 7.0%) and Tanzania (112, 6.8%). Of the 1,655 environmentally suitable implementation units, 960 (58.0%) require more detailed community-level mapping. Our estimates provide key evidence of the population at risk and geographical extent of podoconiosis in Africa, which will help decision-makers to better plan more integrated intervention programmes.

show abstract

“…Mapping podoconiosis is an important prerequisite for the initiation of data-driven national control programmes 57 . Surveying all districts in suspected endemic countries will be resource intensive and will take time.…”

Section: Discussionmentioning

confidence: 99%

Predicting the Environmental Suitability and Population at Risk of Podoconiosis in Africa

Deribe

Simpson

Pullan

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundPodoconiosis is a type of tropical lymphedema that causes massive swelling of the lower limbs. The disease is associated with both economic insecurity, due to long-term morbidity-related loss of productivity, and intense social stigma. The geographical distribution and burden of podoconiosis in Africa is uncertain.MethodsWe applied statistical modelling to the most comprehensive database compiled to date to predict the environmental suitability of podoconiosis in the African continent. By combining climate and environmental data and overlaying population figures, we predicted the suitability and human population at risk.ResultsIn Africa, environmental suitability for podoconiosis was predicted in 29 countries. By 2020, the total population in areas suitable for podoconiosis was estimated at 114.5 million people, (95% confidence interval: 109.4-123.9) with 16.9 million in areas suitable for both lymphatic filariasis and podoconiosis. Of the total 5,712 implementation units defined by WHO in Africa, 1,655 (29.0%) were found to be environmentally suitable for podoconiosis. The majority of IUs with high environmental suitability are located in Angola (80 IUs), Cameroon (170 IUs), the DRC (244 IUs), Ethiopia (495 IUs), Kenya (217 IUs), Uganda (116 IUs) and Tanzania (112 IUs). Of the 1,655 environmental suitable IUs, 960 (58.0%) require more detailed community-level mappingConclusionsOur estimates provide key evidence of the population at risk and geographical extent of podoconiosis in Africa, which will help decision-makers to better plan more integrated intervention programmes.

show abstract

Prevalence surveys for podoconiosis and other neglected skin diseases: time for an integrated approach

Cited by 6 publications

References 9 publications

Epidemiologic and Genomic Reidentification of Yaws, Liberia

Epidemiologic and Genomic Reidentification of Yaws, Liberia

Predicting the environmental suitability and population at risk of podoconiosis in Africa

Predicting the Environmental Suitability and Population at Risk of Podoconiosis in Africa

Contact Info

Product

Resources

About