Prevalence, Treatment, and Outcome of Infection Due to Extended-Spectrum<i>β</i>-Lactamase–Producing Microorganisms

Apisarnthanarak, Anucha; Mundy, Linda M.

doi:10.1086/503018

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…The fact that third-generation cephalosporins are the most common antibiotics associated with IAU may be partially responsible for the trend of increasingly resistant gram-negative microorganisms in our hospital. [4][5] Data on the incidence and pattern of IAU in tertiary care centers in Thailand are summarized in Table 3.…”

Section: Discussionmentioning

confidence: 99%

“…2 Antibiotic resistance among gram-positive and gram-negative organisms has increased significantly in Thailand. [3][4][5] Despite these concerns, there is a paucity of data regarding IAU in Thailand. We performed 2 period-incidence surveys to assess the incidence and patterns of and factors associated with IAU at a tertiary care hospital.…”

Section: Infect Control Hosp Epidemiol 2006; 27:416-420mentioning

confidence: 99%

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Inappropriate Antibiotic Use in a Tertiary Care Center in Thailand: An Incidence Study and Review of Experience in Thailand

Apisarnthanarak

Danchaivijitr

Bailey

et al. 2006

Infect. Control Hosp. Epidemiol.

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The incidence and patterns of and factors associated with inappropriate antibiotic use were studied in a tertiary care center in Thailand. The incidence of inappropriate antibiotic use was 25%. Admission to the surgical department (adjusted odds ratio, 2.0; P = .02) and to the obstetrics and gynecology department (adjusted odds ratio, 2.0; P = .03) were associated with inappropriate antibiotic use, whereas consultation with an infectious diseases specialist was protective against inappropriate antibiotic use (adjusted odds ratio, 0.15; P = .01).

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Section: Discussionmentioning

confidence: 99%

Section: Infect Control Hosp Epidemiol 2006; 27:416-420mentioning

confidence: 99%

Inappropriate Antibiotic Use in a Tertiary Care Center in Thailand: An Incidence Study and Review of Experience in Thailand

Apisarnthanarak

Danchaivijitr

Bailey

et al. 2006

Infect. Control Hosp. Epidemiol.

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“…86 However, this has not been a universal finding, with several studies showing no significant impact of inappropriate empirical therapy on mortality. 67,[87][88][89][90][91] A meta-analysis of 16 studies suggested increased mortality in bacteremia caused by ESBL producers (RR, 1.85; 95% CI, 1.39-2.47), which increased with delayed therapy (RR, 5.56; 95% CI, 2.9-10.5), although only 1 study controlled for confounders. 92…”

Section: Treatmentmentioning

confidence: 99%

Clinical Management of Infections Caused by Enterobacteriaceae that Express Extended-Spectrum β-Lactamase and AmpC Enzymes

Harris

2015

Semin Respir Crit Care Med

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The production of ?-lactamase is the principal mechanism by which gram-negative bacteria resist the action of ?-lactam antibiotics. In recent decades, there has been an alarming explosion in the diversity, global dissemination, host range, and spectrum of activity of ?-lactamases. This has been most clearly reflected by the marked increase in infections caused by bacteria that express extended-spectrum ?-lactamases (ESBLs). Some bacterial species possess chromosomally encoded broad-spectrum cephalosporinases (AmpC) that may be expressed at high level by mutational loss of regulatory genes and are intrinsic in some common Enterobacteriaceae, such as Enterobacter spp. Recently, high-level AmpC production has also been seen in new species such as Escherichia coli via plasmid acquisition. ESBL and AmpC producers present challenges to susceptibility testing and the selection of appropriate antimicrobial therapy. This review describes the current global epidemiology of ESBL producers, examines reported risk factors for infections caused by gram-negative bacteria that express ESBL or AmpC enzymes, and discusses the options for antimicrobial therapy, including ?re-discovered? older antibiotics and novel agents in development.

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Molecular and Descriptive Epidemiology of Multidrug-Resistant Enterobacteriaceae in Hospitalized Infants

Anderson

Nicholas²,

Sprague³

et al. 2008

Infect. Control Hosp. Epidemiol.

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Hospitalized infants are at significant risk of acquiring MDRE, specifically Enterobacter species, at the study institution. Active surveillance cultures identified colonized patients who likely contributed to the institutional reservoir of MDRE. Molecular epidemiologic studies suggest that both patient-to-patient transmission and de novo acquisition of resistance play a role in the acquisition of these organisms, and that the clinical significance of such acquisition varies by species. The high percentage of E. aerogenes isolates that demonstrated genetic clustering suggests that monitoring the prevalence of this organism could serve as a useful measure of compliance with infection control procedures.

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Prevalence, Treatment, and Outcome of Infection Due to Extended-Spectrumβ-Lactamase–Producing Microorganisms

Cited by 4 publications

References 5 publications

Inappropriate Antibiotic Use in a Tertiary Care Center in Thailand: An Incidence Study and Review of Experience in Thailand

Inappropriate Antibiotic Use in a Tertiary Care Center in Thailand: An Incidence Study and Review of Experience in Thailand

Clinical Management of Infections Caused by Enterobacteriaceae that Express Extended-Spectrum β-Lactamase and AmpC Enzymes

Molecular and Descriptive Epidemiology of Multidrug-Resistant Enterobacteriaceae in Hospitalized Infants

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