Prevalence trends in the characteristics of patients with allergic asthma in Beijing, 1994 to 2014

Abstract

This study aimed to determine the clinical profiles and prevalence trends during 1994 to 2014 among patients with allergic asthma (AA), which is a clinical phenotype of asthma.We retrospectively analyzed the characteristics of 319 patients who were diagnosed with AA between March 1, 1994 and February 28, 2014 at 3 Beijing centers.The patients included 155 males and 164 females, and the mean age was 50.86 ± 15.27 years (range 13–86 years). The proportions of asthma attacks in summer and autumn were 60.7% (1994–1999), 61.8% (1999–2004), 56.4% (2004–2009), and 33.1% (2009–2014). The most frequently used medication at home was theophylline (27.9%), which was followed by inhaled corticosteroids (20.38%), inhaled corticosteroids/long-acting beta-2-agonists (10.66%), and leukotriene receptor antagonists (9.4%). The elderly group had the highest rates of summer and autumn attacks, multiple hospitalizations, reduced pulmonary function, smoking history, and positive allergen tests. The middle-aged group had the lowest rates of summer and autumn attacks, and multiple hospitalizations. The youngest group had the lowest rates of reduced pulmonary function, smoking history, and positive allergen tests. The top 5 allergens were dust (9.1%), mites (8.8%), seafood (8.2%), pollen (6.3%), and animal fur (6%). Women were significantly more likely to have a positive allergen test (93 women vs 68 men).The present study revealed the characteristics of Chinese patients with AA, and allergen-specific differences in sex and age during 1994 to 2014. The use of therapeutic drugs at home remains insufficient.

Prevalence of allergen sensitization among 15,534 patients with suspected allergic diseases in Henan Province, China

“…[18][19][20] But in this study, the results indicated that in this region male patients were more likely to be sensitive to allergens, and the sIgE positive rates of all individual allergens except cowry and mold mix were higher in males than females (Figure 1). This result was consistent with the findings in two previous studies.…”

“…14,20,26 However, this is the first large-scale study to report the prevalence of allergen sensitization among patients with suspected allergic diseases in Henan Province, a central region of China. The finding in this study may also be applicable in other provinces in the central region of China which have similar climates, lifestyles to Henan, but further studies are needed to provide evidence.…”

Just breathe: a review of sex and gender in chronic lung disease

“…Taken together, these data suggest importance differences in the underlying biology of asthma between males and females. Female sex has been identified as a risk factor for low health-related quality of life in asthma [100]. Females have a higher frequency of non-allergic asthma than males and have a higher frequency of healthcare contacts and hospitalisations indicating more severe asthma, which is also reflected in 2011 data from the Centers for Disease Control and Prevention showing a 30% increase in mortality from asthma in females compared to males [101].…”

Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mechanism Underlying Paeoniflorin for the Treatment of Allergic Asthma

“…However, these treatments are not effective for all patients (Tan et al, 2016). What’s worse, remarkable, reproducible and undesirable side effects of systemic corticosteroids can also be seen in treatment (Luo et al, 2017; Mao et al, 2017). Therefore, searching for a new antiasthmatic agent is a furious research field.…”