Prevalence, variability, and outcomes in portal hypertensive colopathy: a study in patients with cirrhosis and paired controls

Guimarães, Renata Rangel; Perazzo, Hugo; Machado, Lílian; Terra, Carlos; Perez, Renata M.; Figueiredo, Fábio P.

doi:10.1016/j.gie.2015.01.036

Cited by 10 publications

(3 citation statements)

References 27 publications

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“…The current work acknowledged the high prevalence of colopathic lesions (91.7%) in patients with HCVinduced cirrhosis. In literature studies, the prevalence of colopathy among patients with cirrhosis varies widely from 25% to more than 80% [15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the prevalence of colopathy might be underestimated when the patients present with milder forms, such as colitis-like changes or nonspecific vascular lesions. Also, some studies investigated patients on the basis of the absence of esophageal varices [18]. Moreover, we might have included patients with more severe liver disease in our study than the other studies.…”

Section: Discussionmentioning

confidence: 99%

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Portal hypertensive colopathy in Egyptian cirrhotic patients: an endoscopic study

et al. 2018

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Background Hepatitis C virus (HCV) infection is a major health problem in Egypt. It is often complicated by liver cirrhosis and portal hypertension, resulting in gastroesophageal varices, gastropathy, and colopathy. However, there is still lack of data with respect to the prevalence and clinical relevance of colopathy in this kind of liver disease. The aim of this study was to determine the prevalence of colopathic lesions in HCV-related cirrhotic patients, and to study their associations with the severity of liver disease and manifestations of portal hypertension Patients and methods This cross-sectional study included 60 patients with liver cirrhosis who were submitted to thorough clinical, laboratory, and ultrasonographic examinations. In addition, both upper and lower gastrointestinal endoscopy were performed to detect portal hypertensive complications including colopathic lesions. According to their severity, colopathic lesions were graded into three grades. Patients with higher colopathic grading (grade 2 and 3) were compared with the remaining participants with respect to the severity of the liver disease and other manifestations of portal hypertension. Results The prevalence of colopathy in cirrhotic patients with underlying HCV etiology was 91%. Patients with higher grades of colopathy were characterized by more severe liver disease. Moreover, they had increased frequency of both esophageal and gastric varices, and prior sclerotherapy or band ligation, as well as more collaterals and gastropathy, and higher grades of esophageal varices. Conclusion Colopathic lesions are frequent in patients with HCV-induced cirrhosis. Getting endoscopic treatment for varices is a risk factor for developing higher grades of colopathy. The latter could be considered as a marker of a worse prognosis in patients with HCV cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Portal hypertensive colopathy in Egyptian cirrhotic patients: an endoscopic study

et al. 2018

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“… 11 , 12 When studying this pathology, the authors used the terms “portal hypertension duodeno-enteropathy and colonopathy”. 12 – 15 They observed clinically significant portal colonopathy in 42% of patients with hepatic cirrhosis in the form of edema and atrophy of the intestinal mucosa (in 95% of patients), vasodilatation, and thickening of the walls (in 100%). 16 In addition, it has been proven that severe portal hypertension led to microbiota disturbance, resulting in oxidative stress, which is the cause of anemia, inflammation of the abdominal aorta, spontaneous bacterial peritonitis, and hepatic encephalopathy.…”

Section: Discussionmentioning

confidence: 99%

<p>Increases in Autoantibody Level Associated with Degenerative Changes in the Intestinal Mucosa in Liver Cirrhosis</p>

Karpova¹,

Russkova²,

Lavrentieva³

2020

CEG

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Background: Portal hypertensive colonopathy is a consequence of portal hypertension that develops in hepatic cirrhosis. Pathological processes occurring in intestinal epithelium cells can be revealed by changes in the autoantibody titers to intestinal antigens. It is important both in diagnosis and in the evaluation of the treatment effectiveness. Purpose: To investigate the effect of portal hypertension in patients with liver cirrhosis on degenerative processes in the walls of the small and large intestines after stimulation of liver regeneration with cryoprecipitate. Methods: Thirty-six patients with liver cirrhosis underwent a procedure for percutaneous introduction of cryoprecipitate into the liver tissue. Before and 1 year after it, all the patients were measured for portal blood flow parameters, performed colonoscopy with biopsy, and determined autoantibodies to intestinal antigens (ItM, SCM) in the blood. Comparative analyses of changes in the large intestine mucosa before and after reducing portal hypertension by stimulating liver regeneration with cryoprecipitate were conducted. Results: Here, we show that the degenerative process in the mucosa of the intestines increases, despite the positive dynamics of portal blood flow parameters after the liver regeneration. Autoantibodies values for the intestine antigens were higher than normal in 22 of the 36 patients after 1 year of introduction of cryoprecipitate into the liver. Morphological analysis of the intestinal wall showed the presence of edema/mucosal atrophy and neutrophilic/lymphocytic-histiocytic infiltration in 28 of the 36 patients. Conclusion: Changes in autoantibodies to intestinal antigens are an informative method for diagnosing colonopathy and enteropathy at early stages, providing the possibility to administer proper timely treatment. Patients with hepatic cirrhosis are recommended to have their intestinal microflora tested and be administered drugs that improve their composition.

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Drug-Induced Injury, Vascular, Congenital, Motility, Polyps, and Miscellaneous Disorders

Chandan

2019

Surgical Pathology of Non-Neoplastic Gastrointestinal Diseases

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Prevalence, variability, and outcomes in portal hypertensive colopathy: a study in patients with cirrhosis and paired controls

Cited by 10 publications

References 27 publications

Portal hypertensive colopathy in Egyptian cirrhotic patients: an endoscopic study

Portal hypertensive colopathy in Egyptian cirrhotic patients: an endoscopic study

<p>Increases in Autoantibody Level Associated with Degenerative Changes in the Intestinal Mucosa in Liver Cirrhosis</p>

Drug-Induced Injury, Vascular, Congenital, Motility, Polyps, and Miscellaneous Disorders

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