Prevalência ambulatorial em um hospital geral de marcadores para hepatites B e C em pacientes com infecção pelo vírus da imunodeficiência humana

Tovo, Cristiane Valle; Santos, Diogo Edele dos; Mattos, Ângelo Zambam de; Almeida, Paulo Roberto Lerias de; Mattos, Ângelo Alves de

doi:10.1590/s0004-28032006000200002

Cited by 27 publications

(14 citation statements)

References 35 publications

(45 reference statements)

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“…HBV/HIV and HCV/HIV prevalences were 3.7% and 5.4% respectively. These are in accordance with other Brazilian published data, in which values ranged from 2.8%-4.6% for HBV/HIV co-infection (7,15,19) and 4%-6.4% for HCV/HIV association (6,7,17) . Similar to our study, these researches tested HIV patients who were in medical follow-up in infectious disease centers in four distinct Brazilian cities: São Paulo, Porto Alegre, Amazonas and Vitória.…”

Section: Discussionsupporting

confidence: 93%

“…Other studies report the same difficulty in testing patients for hepatitis. Tovo et al found that only 58.4% (343/587) of the HIV patients on medical follow-up in a tertiary unit in south Brazil were tested for either HBV or HVC serologies (15) . Other authors, however, report successful experiences, which leaded to better results.…”

Section: Discussionmentioning

confidence: 99%

“…Also a significant number of co-infected individuals are asymptomatic carriers of hepatitis viruses, which leads to a delayed diagnosis and under notification. In brazilian studies, HBV/HIV prevalence ranges from 2.8% to 4.8%, whereas HCV/HIV co-infection rates vary from 4.4% to 36.2% (6,14,15,17,19) . The present study aimed to determine the prevalence of the HBV and HCV infection in a recently diagnosed HIV population in the state of Ceará -Brazil.…”

Section: Hepatitis B C and Hiv Co-infections Seroprevalence In A Normentioning

confidence: 99%

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Hepatitis B, C and Hiv Co-Infections Seroprevalence in a Northeast Brazilian Center

Távora

Hyppolito

Cruz³

et al. 2013

Arq. Gastroenterol.

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ContextThe occurrence of HIV and hepatitis B (HBV) and C (HCV) virus associations is of great concern since co-infected patients respond poorly to antiviral treatment and usually progress to chronic and more complicated hepatic disease. In Brazil, these co-infections prevalence is not well known since published data are few and sometimes demonstrate conflicting results. Also, a significant number of co-infected individuals are HBV/HCV asymptomatic carriers, leading to under notification.ObjectivesThe present study aimed to determine the prevalence of the HBV and HCV infection in a recently diagnosed HIV population in the state of Ceará/Brazil.MethodsRetrospective cohort, with >18yo patients diagnosed HIV+ from 2008-2010. First year medical attention information was collected.ResultsA total of 1.291 HIV+ patients were included. HBV serologies were collected in 52% (23% had previous hepatitis B, 3.7% were co-infected) and HCV in 25.4% (1.5% had previous hepatitis C, 5.4% co-infection). The majority of HBV/HIV patients referred multiple sexual partners/year, 28% homosexualism and 20% bisexualism. In the HCV/HIV group 38.8% individuals had > one sexual partner/year and 22.2% used intravenous drugs.ConclusionThe study reinforce the need for better training healthcare workers and providing laboratory support for a prompt hepatitis diagnosis and adequate medical management to avoid complications and decrease viral spread.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Hepatitis B C and Hiv Co-infections Seroprevalence In A Normentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis B, C and Hiv Co-Infections Seroprevalence in a Northeast Brazilian Center

Távora

Hyppolito

Cruz³

et al. 2013

Arq. Gastroenterol.

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“…In general, patients with hepatic steatosis due to the obesity, alcohol consumption or DM respond to treatment less frequently than patients without steatosis (6) and in HIV co-infected patients the virologic response frequency is lower than the patients without co-infection (17) . The epidemiological results presented by TOVO et al (18) , GALPERIM et al (8) and PAROLIN et al (14) are important for public health decision making, because they refl ect the reality found in daily clinical practice. In Brazil, where most high cost medical treatment has been defrayed by the government it is important to perform local pharmacoeconomical studies.…”

Section: Hepatitis C -Facts In Numbersmentioning

confidence: 92%

“…In the fi rst, TOVO et al (18) , describe the frequency of HBV-HIV and HCV-HIV co-infections, being important the association of HCV. Among those who tested for anti-HCV, 126/330 (38.2%) were positive, being the use of intravenous drug abuse (75.3%) the main risk factor in this group.…”

Section: Hepatitis C -Facts In Numbersmentioning

confidence: 99%

Hepatitis C: facts in numbers

Ono‐Nita¹,

Nita²,

Carrilho³

2006

Arq. Gastroenterol.

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High frequency of lamivudine resistance mutations in Brazilian patients co‐infected with HIV and hepatitis B

Mendes-Corrêa

Pinho

Locarnini

et al. 2010

Journal of Medical Virology

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This study analyzed the genotype distribution and frequency of lamivudine (LAM) and tenofovir (TDF) resistance mutations in a group of patients co-infected with HIV and hepatitis B virus (HBV). A cross-sectional study of 847 patients with HIV was conducted. Patients provided blood samples for HBsAg detection. The load of HBV was determined using an "in-house" real-time polymerase chain reaction. HBV genotypes/subgenotypes, antiviral resistance, basal core promoter (BCP), and precore mutations were detected by DNA sequencing. Twenty-eight patients with co-infection were identified. The distribution of HBV genotypes among these patients was A (n = 9; 50%), D (n = 4; 22.2%), G (n = 3; 16.7%), and F (n = 2; 11.1%). Eighteen patients were treated with LAM and six patients were treated with LAM plus TDF. The length of exposure to LAM and TDF varied from 4 to 216 months. LAM resistance substitutions (rtL180M + rtM204V) were detected in 10 (50%) of the 20 patients with viremia. This pattern and an accompanying rtV173L mutation was found in four patients. Three patients with the triple polymerase substitution pattern (rtV173L + rtL180M + rtM204V) had associated changes in the envelope gene (sE164D + sI195M). Mutations in the BCP region (A1762T, G1764A) and in the precore region (G1896A, G1899A) were also found. No putative TDF resistance substitution was detected. The data suggest that prolonged LAM use is associated with the emergence of particular changes in the HBV genome, including substitutions that may elicit a vaccine escape phenotype. No putative TDF resistance change was detected after prolonged use of TDF.

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Prevalência ambulatorial em um hospital geral de marcadores para hepatites B e C em pacientes com infecção pelo vírus da imunodeficiência humana

Cited by 27 publications

References 35 publications

Hepatitis B, C and Hiv Co-Infections Seroprevalence in a Northeast Brazilian Center

Hepatitis B, C and Hiv Co-Infections Seroprevalence in a Northeast Brazilian Center

Hepatitis C: facts in numbers

High frequency of lamivudine resistance mutations in Brazilian patients co‐infected with HIV and hepatitis B

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