Prevalência da infecção pelo HTLV-1, em remanescentes de quilombos no Brasil Central

Nascimento, Laura Branquinho do; Carneiro, Megmar Aparecida dos Santos; Teles, Sheila Araújo; Lopes, Carmen Luci Rodrigues; Reis, Nádia Rúbia da Silva; Silva, Ágabo Macedo da Costa e; Motta-Castro, Ana Rita Coimbra; Otsuki, Koko; Vicente, Ana Carolina Paulo; Martins, Regina Maria Bringel

doi:10.1590/s0037-86822009000600009

Cited by 18 publications

(18 citation statements)

References 23 publications

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“…This percentage is considered high, indicating there should be greater attention given to HTLV-related diseases in this population. This prevalence is 40 and 52 times higher than those found in prime blood donors (0.17%) and pregnant women (0.13%) from Campo Grande (Central-West Brazil), respectively, and 13.6 times higher than that found in African descendants residing in Central Brazil (0.5%) [ 10 , 11 , 12 ]. In another study conducted with Japanese immigrants in the city of Tome-Açu in northern Brazil, the prevalence (2.8%) was smaller than that found in this study [ 13 ].…”

Section: Discussionmentioning

confidence: 62%

High Prevalence of HTLV-1 Infection among Japanese Immigrants in Non-endemic Area of Brazil

et al. 2015

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BackgroundHuman T-lymphotropic virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in many world regions, including southwestern Japan and Brazil. Japanese immigrants and their descendants have a high risk of acquiring this infection due to intense population exchange between Brazil and Japan.ObjectiveThis cross-sectional study aimed to estimate the prevalence of HTLV, analyze the main risk factors associated with this infection, identify the main circulating types and subtypes of HTLV in Japanese immigrants and descendants living in Campo Grande-MS (Middle-West Brazil), as well as analyze the phylogenetic relationship among isolates of HTLV.Study DesignA total of 219 individuals were interviewed and submitted to blood collection. All collected blood samples were submitted for detection of anti-HTLV-1/2 using the immunoassay ELISA and confirmed by immunoblot method. The proviral DNA of the 14 samples HTLV- 1 positive were genotyped by nucleotide sequencing.ResultsThe overall prevalence of HTLV-1 was 6.8% (IC 95%: 3,5-10,2). Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years. The proviral DNA of HTLV-1 was detected in all HTLV-1 positive samples. Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese).ConclusionThe high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil.

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Section: Discussionmentioning

confidence: 62%

High Prevalence of HTLV-1 Infection among Japanese Immigrants in Non-endemic Area of Brazil

et al. 2015

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“… Most of the reports were performed in Brazil, Peru and Jamaica; all of them are considered endemic regions , , . …”

Section: Methodsmentioning

confidence: 99%

Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America

Eusebio‐Ponce

Candel

Anguita

2019

Tropical Med Int Health

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This narrative review, which is based on a systematic literature search following the PRISMA guidelines, provides a general overview of Human T-cell Lymphotropic Virus type 1 (HTLV-1) and associated diseases: Adult T-cell Leukaemia-Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in Latin America, focusing on epidemiology and prevention. Using the published information on HTLV-1, ATLL and HAM/TSP prevalence, we present comprehensive and accurate maps and tables, and developed an algorithm to assist in the prevention of HTLV-1 transmission through breastfeeding while considering socio-economic status. Latin America is an interesting scenario to study HTLV-1 because of the diverse origin of its population. Apart from the expected high prevalence in inhabitants of African ancestry, the presence of endemic foci affecting indigenous populations is particularly striking. ATLL prevention is the biggest challenge in this field. Most ATLL cases are transmitted through breastfeeding; thus, prevention methods to avoid ATLL in endemic countries have to be focused on this. In view of the high inequality in most Latin American countries, reduction in breastfeeding duration, freezing/ thawing and pasteurisation of breastmilk can be suitable interventions in poor settings, considering that avoiding the risk of malnutrition and infant mortality must be the priority.

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“…The Quilombo settlements in central Brazil present a prevalence of HTLV-1 of 0.5%, 8 whereas São Luís, the capital of the State of Maranhão, Northeastern Brazil, has a high prevalence rate of 10:1,000 habitants 9 …”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of HTLV-1/2 among blood donors in the state of Maranhão, Brazil

Viana

Nascimento

Oliveira

et al. 2014

Revista Brasileira de Hematologia e Hemoterapia

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BackgroundInfection with human T-lymphotropic virus 1 or 2 (HTLV-1/2) is a major health problem. There is a public health policy defining measures for state hematology and hemotherapy centers in Brazil, in order to avoid virus transmission through blood donors.ObjectiveThis study aimed to evaluate the seroprevalence of HTLV-1/2 in blood donors in the State of Maranhão, Brazil, during routine blood unit screening.MethodsScreening tests of blood donors using the enzyme-linked immunosorbent assay (ELISA) to detect seropositivity for HTLV-1/2 performed at the Hematology and Hemotherapy Center of the State of Maranhão (HEMOMAR) between July of 2003 and December of 2009 were retrospectively evaluated.ResultsOf the 365,564 blood donors, 561 (0.15%) were HTLV-1/2-positive, of whom 72 (12.8%) performed the confirmatory test (Western blot). In donors who had a confirmatory test, 53 (73.6%) were positive. The ages of the infected individuals ranged from 18 to 65 years; 305 (54%) were aged over 40 years. Among the infected individuals, 309 (55%) were male, 399 (71%) were mixed-race, and 259 (46%) were single. Co-infections were frequently found, especially with hepatitis B (in 68.6% of the cases).ConclusionThe results obtained will contribute to the planning and implementation of control measures by the epidemiological surveillance agency of Maranhão, and will also contribute to reducing morbidity. The high seropositivity in a small sample in donors who had confirmatory tests indicates the need for confirmatory tests for all donors who initially test as seropositive.© 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. All rights reserved.

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Prevalência da infecção pelo HTLV-1, em remanescentes de quilombos no Brasil Central

Cited by 18 publications

References 23 publications

High Prevalence of HTLV-1 Infection among Japanese Immigrants in Non-endemic Area of Brazil

High Prevalence of HTLV-1 Infection among Japanese Immigrants in Non-endemic Area of Brazil

Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America

Seroprevalence of HTLV-1/2 among blood donors in the state of Maranhão, Brazil

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