Prevalencia de hipercolesterolemia en la población estudiantil de una localidad de la provincia de Córdoba

Lubetkin, A; Robledo, Jorge; Siccardi, Leonardo J; Rodriguez, María Inés

doi:10.4067/s0370-41062007000100015

Cited by 6 publications

(7 citation statements)

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“…Then in 2003, out of 1050 subjects in the same age group, the percentage of individuals with that cholesterol level had increased to 39.2%. 19 As a result, between 2003 and 2005, an education intervention aimed at the promotion of healthy habits was successfully implemented in all schools. 20 The results of these experiences led to the formulation of this study's purpose and objectives.…”

Section: Discussionmentioning

confidence: 99%

Relationship between genetic and environmental factors and hypercholesterolemia in children

2016

Arch Argent Pediat

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Introduction. Pediatric hypercholesterolemia has increased over the past decades. Knowing the environmental and genetic factors that have an impact on it would allow establishing more adequate screening guidelines. Objectives. To determine if there is an association between genetic and environmental factors and hypercholesterolemia in children. To assess the predictive qualities of outcome measures associated with hypercholesterolemia. Material and methods. Observational, analytical, cross-sectional study. Population: students from all schools located in Jovita. Age: ≥ 6 and < 12 years old. The total cholesterol level was measured. A survey was administered to parents to assess their family medical history (FMH) and socioeconomic level (SEL). Weight and height were recorded to establish nutritional status. A survey was administered to children to identify their level of physical activity and their eating habits. The association was assessed by estimating the OR value (p < 0.05). Diagnostic tests were done to establish outcome measures that predict hypercholesterolemia. Results. Three hundred and eighty-two students were included. Their mean cholesterol level was 168 mg/dL, and 13.4% had hypercholesterolemia. A sedentary lifestyle was observed in 22.8%, and obesity, in 10.5%. A positive FMH, a high/ middle SEL, and obesity were associated with hypercholesterolemia (OR: 2.10, 2.10 and 2.05, respectively). No association was found between physical activity and fat/cholesterol intake and hypercholesterolemia. A positive FMH and a high/middle SEL were sensitive enough (75% and 88%) to predict hypercholesterolemia. The presence of hypercholesterolemia in both parents in relation to hypercholesterolemia in their child showed an OR of 9.59, a sensitivity of 73%, a specificity of 71%, a positive predictive value of 57%, and a negative predictive value of 83%. Conclusions. A positive FMH, a high/ middle SEL, and obesity were associated with hypercholesterolemia in children. The presence of hypercholesterolemia in both parents was associated with hypercholesterolemia in their child and showed itself to be a great potential predictor and screening criterion.

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Section: Discussionmentioning

confidence: 99%

Relationship between genetic and environmental factors and hypercholesterolemia in children

2016

Arch Argent Pediat

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“…I n A r g e n t i n a , t h e p r e v a l e n c e o f c h i l d h o o d hypercholesterolemia is 6-15 % and that of slightly elevated cholesterol level, 15-35 %. [9][10][11] The 1998 and 2011 consensuses b y t h e A m e r i c a n A c a d e m y o f Pediatrics (AAP) 12,8 and the 2005 consensus by the Argentine Society of Pediatrics (Sociedad Argentina de Pediatría, SAP) respectively recommend, as a selective screening s t r a t e g y , t h e m e a s u r e m e n t o f cholesterol levels in children with a positive family medical history (FMH) or an unknown history of early cardiovascular conditions in their parents and grandparents or of hypercholesterolemia in their parents. In its consensus on the management of dyslipemias in pediatrics, the SAP recommends the universal screening in children aged 6 to 11 years but its mass use and costs complicate its implementation.…”

Section: N 1 9 8 3 T H E L I P I D R E S E a R C H Clinics Coronamentioning

confidence: 99%

Parental hypercholesterolemia and family medical history as predictors of hypercholesterolemia in their children

Robledo¹,

Siccardi²,

Gallindo

et al. 2019

Arch Argent Pediat

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Introduction. Parental hypercholesterolemia w o u l d b e a b e t t e r p r e d i c t o r o f hypercholesterolemia than family medical history in children. Objectives. To compare the strength of association and predictive values of parental hypercholesterolemia versus a positive family history in pediatric hypercholesterolemia. Material and methods. Cross-sectional, analytical study. Cholesterol levels were measured in children aged ≥ 6 and < 12 years and in their biological parents. A survey was administered to parents. The association was estimated using the odds ratio (OR), and its predictive value was determined. The relationship between hypercholesterolemia in parents and their children was studied with multilevel regression. Results. A total of 332 children, 304 mothers, and 206 fathers were assessed. A cholesterol level ≥ 240 mg/dL in one or both parents and ≥ 200 mg/dL in children showed: OR= 6.40; 95 % confidence interval (CI)= 2.85-14.48; p < 0.0001; sensitivity= 69 %; specificity= 74 %; positive predictive value (PPV)= 34 %; negative predictive value (NPV)= 93 %; positive likelihood ratio (LR+)= 2.69; negative likelihood ratio (LR-)= 0.42. Family medical history versus children with cholesterol level ≥ 200 showed: OR= 1.86; 95 % CI= 0.84-4.11; p= 0.1272; sensitivity= 69 %; specificity= 46 %; PPV= 19 %; NPV= 89 %; LR+= 1.27; LR-= 0.68. Cholesterol was 2.9 and 2.5 mg/dL higher per every 10 mg/dL of increased cholesterol in mothers and fathers, respectively. Conclusions: Parental hypercholesterolemia w a s s i g n i f i c a n t l y a s s o c i a t e d w i t h hypercholesterolemia in children and showed a higher predictive power than a positive family medical history.

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“…8 En nuestro país, la prevalencia de hipercolesterolemia en niños es del 6 % al 15 % y del 15 % al 35% de colesterolemia ligeramente elevada. [9][10][11] Los consensos de la American Academy of Pediatrics (AAP) de 1998 y 2011 12,8 y de la Sociedad Argentina de Pediatría (SAP) de 2005 13 recomiendan como estrategia de tamizaje selectivo la determinación de colesterolemia en los niños con historia clínica familiar (HCF) positiva o desconocida de patologías cardiovasculares prematuras en los padres y en los abuelos o de hipercolesterolemia en los padres. El consenso de la SAP sobre el manejo de dislipemias en pediatría aconseja el tamizaje universal en niños de 6 a 11 años, pero su aplicabilidad es dificultosa por la masividad y los costos.…”

Section: Introductionunclassified

Hipercolesterolemia en los padres e historia clínica familiar como predictores de hipercolesterolemia en los hijos

2019

Arch Argent Pediat

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Prevalencia de hipercolesterolemia en la población estudiantil de una localidad de la provincia de Córdoba

Cited by 6 publications

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Relationship between genetic and environmental factors and hypercholesterolemia in children

Relationship between genetic and environmental factors and hypercholesterolemia in children

Parental hypercholesterolemia and family medical history as predictors of hypercholesterolemia in their children

Hipercolesterolemia en los padres e historia clínica familiar como predictores de hipercolesterolemia en los hijos

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