The objective was to evaluate the trend of physical activity (PA) and cardiovascular risk factors (CVRF) in a Department of Health in Chile between 2015 and 2019. Records of people ≥15 years of age were analysed to determine the trend of PA, nutritional status, cardiometabolic diseases and lifestyles. The probability that these variables occurred over the years was calculated. A tendency to decrease in PA was found in all cases, in men and women, and an increase in CVRF for all cases and in women; between 2015 and 2019, there was a certain stability in men. Women who consulted for PA in July-September 2019 were more likely to do so compared to men (OR: 2.09, p < .001), women with obesity (OR: 1.81, p < .0001), overweight (OR: 1.91, p < .0001), hypertension (OR: 1.15, p = .01), high blood glucose (OR: 1.36, p < .0001) and smoking (OR: 2.4, p < .0001) were more likely to suffer them compared to men in April-June 2019. It is concluded that the highest and lowest periods in the cases of PA and CVRF could be known, and the probability that these occurred over time could be estimated. PA can be important for the control and treatment of CVRF.