Prevalencia de obesidad y de factores de riesgo cardiovascular en una población de pacientes pediátricos con diabetes tipo 1

Palomo-Atance, Enrique; Muiña, Patricio Giralt; Herrera, M; Cano, Rafael Ruiz; Martín, A. León; Muiña, Juan Giralt

doi:10.1016/j.anpedi.2012.11.011

Cited by 6 publications

(6 citation statements)

References 34 publications

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“…This study revealed that prevalence of hypertriglyceridemia was 37%, which was not dependent to the child's gender. Previously, the prevalence of hypertriglyceridemia was reported in children with T1DM of the Netherlands (2), Spain (15) and Poland (4), which was 21.1%, 2.6% and 16.6%, respectively. Similar to our data, in an Indian population, the prevalence of hypertriglyceridemia was reported as 41.7% in patients with T1DM (26).…”

Section: Discussionmentioning

confidence: 96%

“…In normal Iranian children, metabolic syndrome was reported as 9 to 11% (13), that was less than that of children with T1DM in the present study. Reduction in physi-cal activity in T1DM in the Iranian population (14) and also in T1DM children (15) could also explain, to some extent, such a high prevalence. Several investigations revealed some association between insulin resistance and the presence of chronic complication in T1DM (16,17).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Metabolic Syndrome in Children With Type 1 Diabetes in South of Iran

Saki

2016

J Compr Ped

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Objectives: The aim of this study was to investigate the prevalence of metabolic syndrome, in children with type one diabetes mellitus (T1DM) for the first time in a population in the Middle East, and assess the influence of type of insulin therapy, daily dosage of insulin, family history of type 2 diabetes, gender and level of HbA1c on the prevalence of metabolic syndrome. Methods: This cross-sectional study was conducted on children with T1DM aged < 20 years, and duration of T1DM >2 years during years 2013 to 2014. Waist circumference, blood pressure, height and weight of children with diabetes, for calculation of body mass index (BMI), were measured by one physician. Fasting blood glucose and lipids were also measured. According to the age-modified standards of the ATPIII, metabolic syndrome was defined. All data were analyzed using the SPSS 18 software. Results: In this study, 87 children with diabetes (48 females and 39 males) aged 12.38 ± 4.2 were enrolled. Overall, 40.9% of our patients had hypertension, 55.2% had hypertriglyceridemia, 36.8% had low high-density lipoprotein (HDL) and 6.9% of patients had abdominal obesity. Furthermore, 29.9% of these children had metabolic syndrome, which did not have a significant association with the type of insulin regimen (P = 0.97), nor the daily dosage of insulin (P = 0.234), however the serum concentration of HbA1c had a significant correlation with metabolic syndrome (P = 0.027). Conclusions: This study provides evidence indicating high prevalence of metabolic syndrome in children with T1DM in southern Iran. Preventive programs aimed towards decreasing the risk factors of metabolic syndrome and interpretation of a healthier diet and physical activity for children with T1DM should be considered in our country.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome in Children With Type 1 Diabetes in South of Iran

Saki

2016

J Compr Ped

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“…In a sample from Colorado, 16 % of youths with type 1 diabetes had BMIs above the 85th percentile for age (i.e., equivalent to both overweight and obese groups in our sample) upon diagnosis [17]. In 115 Spanish individuals with type 1 diabetes on intensive therapy, with a mean age of 12 years old and a mean diabetes duration of 5 years, about 30 % were overweight and 20 % were obese [18]. In a sample of American youths from 0 to 17 years old with diabetes, 16.3 % were obese and were classified as obese-indeterminate diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…There was a significant interaction between diabetes duration and familial history of type 2 diabetes, though, which could be related to clinical heterogeneity, partly explaining the irregular pattern of association between HbA1c and other variables. In literature, HbA1c was not correlated with BMI status in children and adolescents [18]. It showed no solid correlation with coronary artery disease (CAD), either [24].…”

Section: Discussionmentioning

confidence: 99%

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Double-diabetes in a real-world sample of 2711 individuals: associated with insulin treatment or part of the heterogeneity of type 1 diabetes?

Giuffrida

Bulcão²,

Cobas

et al. 2016

Diabetol Metab Syndr

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BackgroundDouble diabetes (DD) describes both individuals with obesity upon diagnosis of type 1 diabetes and those who have gained weight during follow-up, although cardiovascular risk factors (CVRF) are not well understood in this group. We aim to evaluate the frequency of DD in a real-world type 1 diabetes sample and the interaction of insulin treatment with CVRF.MethodsMulticentre cross-sectional study of 2711 individuals with clinical diagnosis of type 1 diabetes from secondary diabetes centres in 20 Brazilian cities.ResultsPatients with diabetes duration <5 and ≥5 years had similar frequency of overweight (20.4 vs. 25 %) and obesity, (9.8 vs. 6.1 %), p 0.28 for trend. Insulin dose (U/kg/day) was lower in obese individuals compared to normal BMI, with mean (95 % CI) 0.72 (0.62–0.83) vs. 0.88 (0.84–0.92) U/kg/day for diabetes duration <5 years and 0.84 (0.77–0.92) vs. 0.99 (0.97–1.01) U/kg/day for duration ≥5 years. Obese individuals had lower HDL (47.5 vs. 54.4 mg/dL) and higher non-HDL-cholesterol (134.5 vs. 115.2 mg/dL) than lean ones only among those with more than 5 years of diabetes.ConclusionsLower insulin doses in obese individuals point to a role of clinical heterogeneity in insulin deficiency rather than normal progression of type 1 diabetes. Early obesity in type 1 diabetes is associated to lower HDL-cholesterol and higher number of CVRF. These data suggest a broad landscape of pathophysiological phenomena in double diabetes, rather than simple progression of a homogeneous clinical entity.Electronic supplementary materialThe online version of this article (doi:10.1186/s13098-016-0143-7) contains supplementary material, which is available to authorized users.

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Long-Term Outcomes in Patients with Morbid Obesity and Type 1 Diabetes Undergoing Bariatric Surgery

et al. 2016

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Prevalencia de obesidad y de factores de riesgo cardiovascular en una población de pacientes pediátricos con diabetes tipo 1

Cited by 6 publications

References 34 publications

Prevalence of Metabolic Syndrome in Children With Type 1 Diabetes in South of Iran

Prevalence of Metabolic Syndrome in Children With Type 1 Diabetes in South of Iran

Double-diabetes in a real-world sample of 2711 individuals: associated with insulin treatment or part of the heterogeneity of type 1 diabetes?

Long-Term Outcomes in Patients with Morbid Obesity and Type 1 Diabetes Undergoing Bariatric Surgery

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