Migraine is a hemialgia, which can be moderate or not, and can occur in both sexes. It is understood that it can happen more frequently in females, due to hormonal situations in women. Propranolol was one of the first beta-blockers to be created, developed in 1950 by scientist James W. Black. The initial purpose of this medication was to treat fungi, but after discovering its effectiveness as an adrenaline hormone blocker, it began to be used to treat cardiovascular diseases, hypertension and migraines. The general objective is to evaluate the effectiveness of Propranolol for the treatment of migraine and the specific explanation about migraine; explain the action of the medication as a migraine beta blocker; present the pharmacology of Propranolol and inform about the absorption of the medicine until the analysis of its collective effects. In this article, we will explore what migraines are, the causes, symptoms, diagnosis, treatments and prevention. Propranolol and its pharmacology will also be discussed in depth, through a vast literature review.