Prevalens dan karakteristik penderita retinoblastoma di RSUP Sanglah Denpasar pada tahun 2008-2015

Lastariana, Kadek Ayu Yani; Ariawati, Ketut; Widnyana, Putra

doi:10.15562/medicina.v49i2.109

Cited by 1 publication

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“…The sex distribution in this study was not much different from a global study with 55% males and 45% females 35 . This finding is also in accordance with research conducted in Surabaya (51.5 vs. 48.5%), 13 Bali (54 vs. 46%), 14 Yogyakarta with the overall population of malignancies (57.3 vs. 42.7%), 4 and India (52.9 vs. 47.1%) 15 . This ratio is consistent with the pathogenetics of retinoblastoma that involves a mutation which occurs in the RB1 gene is known to be unrelated to the sex chromosome 1,16 …”

Section: Discussionsupporting

confidence: 90%

“…21 Genetic and clinical examinations in children with a history of parents or siblings suffering from retinoblastoma are important to accelerate diagnosis and therapy, and ultimately improve the quality of life of patients with retinoblastoma. 22 The lag time to diagnosis in this study had a median value of 10.5 months (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). A retrospective study in India reported the delay was only 5 months (1-36).…”

Section: Prognostic Factorsmentioning

confidence: 59%

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Lag time to diagnosis as a predictor of mortality in children with extraocular retinoblastoma: Experience from a developing country

Nindyastuti

Rusmawatiningtyas

Makrufardi

et al. 2022

Asia-Pac J Clncl Oncology

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Aim To define the prevalence of mortality and identify factors associated with mortality in pediatric patients with extraocular retinoblastoma attending the tertiary hospital in Indonesia. Methods We retrospectively collected medical records from 2013 to 2019 of patients who were diagnosed with extraocular retinoblastoma. Cox proportional hazard regression analysis with 95% confidence interval (CI) was used to evaluate the association of mortality predictors with patient outcomes (Hazard Ratio [HR], 95% CI) with significance set as p < .05. Results Overall, 60 patients were included in this study for a retrospective chart review, with 55% males and 45% females. The median age at diagnosis was 13 (5–24) months. About 60% of the patients did not survive, while 2‐year survival probability was 45%. The overall median survival time was 21.5 (7.25–40.75) months. Predictors of mortality were laterality (unilateral/bilateral): HR 2.15 (95% CI: 1.07–4.28; p = .03), nutritional status: HR 2.65 (95% CI: 1.34–5.25; p = .05), and lag time to diagnosis: HR 3.12 (95% CI: 1.56–6.2; p = .001). Conclusion Laterality, nutritional status and lag time to diagnosis were identified to be mortality predictors in extraocular retinoblastoma. The 2‐year survival for children with extraocular retinoblastoma was 45% with 21 months for median survival.

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