Preventability of Adverse Drug Reactions Related to Antibiotics: An Assessment Based on Spontaneous Reporting System

Ha, Tran Ngan; Nguyen, T; Tran, Ngoc Thanh; Nguyen, Ly; Vu, Dinh Hoa; Anh, Nguyen Hoang; Trinh, Nhung T H

doi:10.1007/s43441-023-00552-y

Cited by 2 publications

(4 citation statements)

References 23 publications

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“…Interestingly, the main causes of these preventable AEs were related to prescribing, which included "inappropriate prescribing" (n = 352; 40%), "indicating antibiotics for patients with no sign of infection" (n = 272; 31%), "inappropriate indication for antimicrobial prophylaxis" (n = 49; 6%), "inappropriate indication" (n = 31; 4%), "readministration of antibiotics causing prior allergy/allergies" (n = 99; 11%), and "inappropriate dosing" (n = 26; 3%). These results reveal evidence of AB overuse that the authors say is related to problems such as difficulty in making an adequate diagnosis, high infection pressure, and problems related to prescribers (personal experience and financial interests) [94].…”

Section: Pv As a Tool To Identify Inappropriate Uses Of Antibioticsmentioning

confidence: 76%

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Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use—A Narrative Review

Sandes,

Figueras,

Lima

2024

Preprint

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The spread of antimicrobial resistance (AMR) is a global challenge. Close and continuous surveillance for quick detection of AMR can be difficult, especially in remote places. This narrative review focuses on the contributions of pharmacovigilance (PV) as an auxiliary tool for identifying and monitoring the ineffectiveness of, resistance to, and inappropriate use of antibiotics (ABs). The terms “drug ineffective,” “therapeutic failure,” “drug resistance,” “pathogen resistance,” and “multidrug resistance” were found in PV databases and dictionnaires, and denote ineffectiveness. These terms cover a range of problems that should be better investigated because they are useful in warning about possible causes of AMR. “Medication errors,” especially those related to dose and indication, are highlighted in the literature, suggesting inappropriate use of ABs. Hence, the included studies show that the terms of interest related to AMR are not only present but frequent in PV surveillance programs. This review illustrates the feasibility of using PV as a complementary tool for antimicrobial stewardship activities, especially in scenarios where other resources are scarce.

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Section: Pv As a Tool To Identify Inappropriate Uses Of Antibioticsmentioning

confidence: 76%

“…ABs cause many of the AE reported in PV programs [90][91][92][93][94], especially those in the Watch category [20,31,90]. Interestingly, in addition to the adverse reactions themselves (for example, nausea, vomiting, diarrhoea, hypersensitivity, headache, etc.…”

Section: Pv Strategies Useful For Monitoring the Use Of Abs And Comba...mentioning

confidence: 99%

Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use—A Narrative Review

Sandes,

Figueras,

Lima

2024

Preprint

View full text Add to dashboard Cite

show abstract

Section: Pv As a Tool To Identify Inappropriate Uses Of Antibioticsmentioning

confidence: 76%

“…ABs are one of the drug classes most frequently associated with AEs [93][94][95][96][97], especially those in the Watch category [18,29,93]. Interestingly, in addition to the adverse reactions themselves (for example, nausea, vomiting, diarrhoea, hypersensitivity, headache, etc.…”

Section: Pv Strategies Useful For Monitoring the Use Of Abs And Comba...mentioning

confidence: 99%

Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use—A Narrative Review

Sandes,

Figueras,

Lima

2024

Antibiotics

View full text Add to dashboard Cite

The spread of antimicrobial resistance (AMR) is a global challenge. Close and continuous surveillance for quick detection of AMR can be difficult, especially in remote places. This narrative review focuses on the contributions of pharmacovigilance (PV) as an auxiliary tool for identifying and monitoring the ineffectiveness, resistance, and inappropriate use of antibiotics (ABs). The terms “drug ineffective”, “therapeutic failure”, “drug resistance”, “pathogen resistance”, and “multidrug resistance” were found in PV databases and dictionaries, denoting ineffectiveness. These terms cover a range of problems that should be better investigated because they are useful in warning about possible causes of AMR. “Medication errors”, especially those related to dose and indication, and “Off-label use” are highlighted in the literature, suggesting inappropriate use of ABs. Hence, the included studies show that the terms of interest related to AMR and use are not only present but frequent in PV surveillance programs. This review illustrates the feasibility of using PV as a complementary tool for antimicrobial stewardship activities, especially in scenarios where other resources are scarce.

show abstract

Preventability of Adverse Drug Reactions Related to Antibiotics: An Assessment Based on Spontaneous Reporting System

Cited by 2 publications

References 23 publications

Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use—A Narrative Review

Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use—A Narrative Review

Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use—A Narrative Review

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