Preventable causes of male infertility

Thompson, Sharon E

doi:10.1007/bf00182038

Cited by 16 publications

(10 citation statements)

References 99 publications

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“…Our results are remarkable, because there are a number of studies mentioned in the introduction that did find correlations or a negative effect from cigarette smoking and alcohol intake on semen parameters (Thompson, ; Chia et al ., , ; Goverde et al ., ; Vine et al ., ; Merino et al ., ; Hruska et al ., ; Wong et al ., ; Muthusami & Chinnaswamy, ; Okonofua et al ., ). An explanation could be that, according to a review by Vine (), an effect of smoking on semen parameters could be found between smokers and nonsmokers in fertile men, but this effect diminished as soon as infertile men were included in the analysis (Vine, ; Marinelli et al ., ).…”

Section: Discussionsupporting

confidence: 50%

“…Studies also show biochemical alterations in semen due to smoking, such as increased reactive oxygen species activities and a decline in antioxidant molecules (Rubes et al ., ; Mostafa et al ., ; Kiziler et al ., ; Frey et al ., ; Soares & Melo, ). Multiple studies found negative effects on semen parameters, such as sperm density (Chia et al ., ; Vine et al ., ), total count (Vine et al ., ), motility (Thompson, ; Vine et al ., ), sperm morphology (Thompson, ; Chia et al ., ; Wong et al ., ) and semen volume (Vine et al ., ; Hruska et al ., ). One study found negative effects on all of these sperm characteristics due to cigarette smoke (Merino et al ., ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of alcohol intake and cigarette smoking on sperm parameters and pregnancy

et al. 2012

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Much has been published about smoking and alcohol intake influencing male fertility, sperm parameters and reproductive outcome. However, there is no conclusive agreement about the effects of cigarette smoking and alcohol use on these outcomes and thus no generally accepted guidelines. The combined effect of cigarette smoking and alcohol intake, though, has not been rigorously investigated. Because alcohol consumption and smoking are often seen together, this study focuses on the effect of smoking and drinking habits separately and combined on semen parameters, such as volume, sperm count, motility and morphology, and on pregnancy outcome. These suggested toxic effects are studied in a group of subfertile, asthenozoospermic men (<10% motile spermatozoa), compared with a group of 'proven fertile', healthy men. The extreme asthenozoospermic group has especially been chosen because of the suspected effect, that is, oxidative stress, on sperm motility. In our study, we found that cigarette smoking and alcohol intake did not differ between the subfertile and fertile group. In conclusion, cigarette smoking and alcohol consumption do not appear to significantly affect sperm parameters, such as volume, sperm count, motility and morphology or pregnancy outcome in our study population.

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Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Effect of alcohol intake and cigarette smoking on sperm parameters and pregnancy

et al. 2012

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“…The pathophysiologic causes and mechanisms of the HIV-associated AOH are likely multifactorial, and include (1) poor clinical or nutritional status, (2) use of certain prescription medications used to treat HIV, (3) illicit drugs including opiates and methadone, (4) pituitary dysfunction, (5) hepatitis C coinfection and other opportunistic infections, (6) advancing age and increasing length of time diagnosed with HIV, (7) changes in body composition, (8) increased levels of estradiol and increased levels of SHBG, (9) normal age-related declines, (10) low CD4 cell count, (11) high HIV viral load and disease progression, (12) lean body mass, (13) MetS, and (14) wasting lipodystrophy. [38][39][40][41][42][43][44][45][46] Adult-Onset Hypogonadism and Medication Effects Testosterone levels can be affected by many pharmacologic agents 47 that are frequently administered to or used by men (eg, opioids, glucocorticoids, cimetidine, tricyclic antidepressants, nicotine, and marijuana). Men who use high doses of anabolic steroids often find that their T levels fall to castrate levels after stopping these drugs.…”

Section: Adult-onset Hypogonadism and Human Immunodeficiency Virusmentioning

confidence: 99%

Adult-Onset Hypogonadism

Khera

Broderick

Carson

et al. 2016

Mayo Clinic Proceedings

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In August 2015, an expert colloquium commissioned by the Sexual Medicine Society of North America (SMSNA) convened in Washington, DC, to discuss the common clinical scenario of men who present with low testosterone (T) and associated signs and symptoms accompanied by low or normal gonadotropin levels. This syndrome is not classical primary (testicular failure) or secondary (pituitary or hypothalamic failure) hypogonadism because it may have elements of both presentations. The panel designated this syndrome adult-onset hypogonadism (AOH) because it occurs commonly in middle-age and older men. The SMSNA is a not-for-profit society established in 1994 to promote, encourage, and support the highest standards of practice, research, education, and ethics in the study of human sexual function and dysfunction. The panel consisted of 17 experts in men's health, sexual medicine, urology, endocrinology, and methodology. Participants declared potential conflicts of interest and were SMSNA members and nonmembers. The panel deliberated regarding a diagnostic process to document signs and symptoms of AOH, the rationale for T therapy, and a monitoring protocol for T-treated patients. The evaluation and management of hypogonadal syndromes have been addressed in recent publications (ie, the Endocrine Society, the American Urological Association, and the International Society for Sexual Medicine). The primary purpose of this document was to support health care professionals in the development of a deeper understanding of AOH, particularly in how it differs from classical primary and secondary hypogonadism, and to provide a conceptual framework to guide its diagnosis, treatment, and follow-up.

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“…Concomitantly, the incidence of male infertility has been increasing in Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/envres industrial countries year after year, now affecting 25% of young men (Kumar and Singh, 2015;Thompson, 1993). The actual prevalence of male fertility leads to socio-economic changes in clinical management of infertile couples (Inhorn and Patrizio, 2015).…”

Section: Introductionmentioning

confidence: 98%