Preventable Effects of Aloe Vera, Nigella sativa, Moringa oleifera oils and Mixture of them on Aspirin Induced Acute Gastric Ulcer in Experimental Rats.

Abstract

Peptic ulcer disease (PUD) is one of the most common human diseases which affect approximately 50% of the world's population characterized by mucosal damage due to many factors including infections, alcohol, smoking and certain medications. It appears as a break in the lining of the gastrointestinal mucosa that occurs by abnormal function of acid and pepsin. This study was conducted to evaluate the preventable effects of Aloe Vera, Nigella Sativa, Moringa Oleifera oils and mixture of them on aspirin induced acute gastric ulcer in rats. Thirty male albino rats (18010g b.wt. each) were used in this study and classified into 6 groups, 5 rats each, one of them used as control negative (c-ve) group while the other 5 groups had orally taken aspirin at a dose of 200mg/kg b.wt., for gastric ulcer induction, one of them was left as control positive (c+ve) and the rest four groups had orally taken Aloe Vera, Nigella sativa, Moringa Olifera oils and Mixture of them at a dose of 200mg/kg b. wt., each, respectively. Body weight gain (BWG), stomach weights, the length of gastric ulcer, the volume of gastric juice and stomachs histopathological changes were examined. The results concluded that rat groups which orally ingested with Aloe Vera, Nigella sativa, Moringa Olifera oils and their mixture had increased body weight gain and stomach weights with reduced length of gastric ulcer. The volume of gastric juice increased with improvement in stomachs histological structure. Moreover, the best preventable groups were Aloe Vera and Nigella sativa oils compared with the control positive compared to other preventable groups concerning the healing of the gastric ulcer length. Accordingly,

Aloe vera gel confers therapeutic effect by reducing pyroptosis in ethanol-induced gastric ulcer rat model: Role of NLRP3/GSDMD signaling pathway

“…Lectins prevent parietal cells from absorbing aminopyrine. So, reducing stomach acid is due to a direct impact on acid-secreting cells [ 42 ]. When pantoprazole is compared to Aloe vera , pantoprazole causes a high rise in gastric pH, which hinders iron and calcium absorption and inhibits the pepsin enzyme, which requires a lower pH to function properly.…”