Preventing Lethal Prostate Cancer with Diet, Supplements, and Rx: Heart Healthy Continues to Be Prostate Healthy and “First Do No Harm” Part I

Moyad, Mark A.

doi:10.1007/s11934-018-0846-4

Cited by 6 publications

(2 citation statements)

References 98 publications

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“…Another limitation was the use of DXA assessment for the measurement of body composition. The use of DXA for this purpose has been criticized recently, with individual error rates as high as 8%–10% (54,55). However, DXA is generally accepted as an appropriate method for comparison of group means, with group error estimates between 2% and 3% (56).…”

Section: Discussionmentioning

confidence: 99%

Continuous versus Intermittent Dieting for Fat Loss and Fat-Free Mass Retention in Resistance-trained Adults: The ICECAP Trial

Peos

Helms

Fournier

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction: Can intermittent energy restriction (IER) improve fat loss and fat-free mass retention compared with continuous energy restriction (CER) in resistance-trained adults?Methods: Sixty-one adults (32 women) with mean (SD) age 28.7 (6.5) years, body weight 77.2 (16.1) kg and body fat 25.5 (6.1)% were randomized to 12 weeks of (1) 4 x 3-weeks of moderate (m) energy restriction interspersed with 3 x 1-weeks of energy balance (mIER; n=30; 15 weeks total), or (2) 12 weeks of continuous moderate energy restriction (mCER; n=31).Analyses of all outcome measures were by intention-to-treat.Results: After accounting for baseline differences, mIER did not result in lower fat mass or body weight, or greater fat-free mass, compared to mCER after energy restriction. Mean (and 97.5% confidence interval, CI) for fat mass at the end of mIER versus mCER was 15.3 (12.5 to 18.0) kg versus 18.0 (14.3 to 21.7) kg (P=0.321), for fat-free mass was 56.7 (51.5 to 61.9) kg versus 56.7 (51.4 to 62.0) kg (P=0.309), and for body weight (with 95% CI) was 72.1 (66.4 to 77.9) versus 74.6 (69.3 to 80.0) (P=0.283). There were no differences between interventions in muscle strength or endurance or in resting energy expenditure, leptin, testosterone, insulin like growth factor-1, free 3,3′,5-triiodothyronine or active ghrelin, nor in sleep, muscle dysmorphia or eating disorder behaviours. However, participants in mIER exhibited lower hunger (P=0.002) and desire to eat (P=0.014) compared to those in mCER, and greater satisfaction (P=0.016) and peptide YY (P=0.034).Conclusions: Similar fat loss and fat-free mass retention are achieved with mIER and mCER during 12 weeks of energy restriction; however, mIER is associated with reduced appetite.

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Section: Discussionmentioning

confidence: 99%

Continuous versus Intermittent Dieting for Fat Loss and Fat-Free Mass Retention in Resistance-trained Adults: The ICECAP Trial

Peos

Helms

Fournier

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

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“…Therefore, the need for well-designed trials to expand the existing knowledge, replicate the findings, and aggregate the results is necessitated [ 231 ]. Moreover, the efficacy of supplements and, in particular, antioxidants, in tampering down PSA concentrations is questionable and a “first do not harm” concept must prevail before the formulation of any recommendations [ 232 ]. Given that the majority of evidence outlined in the present review revealed little or no effect, it can be assumed that nutrition-wise, PSA is not as sensitive as we might think, whereas the role of nutrition in down-regulating PSA concentrations appears to be minimal.…”

Section: Discussionmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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The quest for dietary patterns and supplements efficient in down-regulating prostate-specific antigen (PSA) concentrations among men with prostate cancer (PCa) or increased PCa risk has been long. Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea catechins, cernitin, vitamins (C, E, D) and multivitamins, medicinal mushrooms (Ganoderma lucidum), fruit extracts (saw palmetto, cranberries, pomegranate), walnuts and fatty acids, as well as combined supplementations of all, have been examined in randomized controlled trials (RCTs) in humans, on the primary, secondary, and tertiary PCa prevention level. Despite the plethora of trials and the variety of examined interventions, the evidence supporting the efficacy of most dietary factors appears inadequate to recommend their use.

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Building a Prostate Cancer Lifestyle Medicine Program

Dovey

Tewari

2020

Creating a Lifestyle Medicine Center

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Preventing Lethal Prostate Cancer with Diet, Supplements, and Rx: Heart Healthy Continues to Be Prostate Healthy and “First Do No Harm” Part I

Cited by 6 publications

References 98 publications

Continuous versus Intermittent Dieting for Fat Loss and Fat-Free Mass Retention in Resistance-trained Adults: The ICECAP Trial

Continuous versus Intermittent Dieting for Fat Loss and Fat-Free Mass Retention in Resistance-trained Adults: The ICECAP Trial

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Building a Prostate Cancer Lifestyle Medicine Program

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