Preventing male infertility by marjoram and sage essential oils through modulating testicular lipid accumulation and androgens biosynthesis disruption in a rat model of dietary obesity

Abstract

Preventing male infertility by marjoram and sage essential oils through modulating testicular lipid accumulation and androgens biosynthesis disruption in a rat model of dietary obesity, Egyptian

Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress

“…In contrast, a decline in weight, adiposity index, leptin and prolactin levels were observed. Likewise, sperm count and the testicular structure were comparable with that of the normal group [104]. In a related study, a synergistic action of OM and grape seed extract on reproductive function was evaluated by using ethanol to induce oxidative stress and reproductive disturbances.…”

Potential Impact of Marjoram on Coragen-Induced Physiological and Histological Alterations in Male Albino Rats

“…In this context, the administration of marjoram to coragentreated rats was functioning in adjusting the plasma levels of sex hormones to a considerable degree. El-Wakf et al [37] reported a similar increase in the testosterone hormone level by marjoram that could be attributed to the direct effect of marjoram extracts on the hypothalamus-pituitary-testis axis. Furthermore, they demonstrated that marjoram is a rich source of terpenoids, asthymol, carvacrol, 4-terpineol, γ-terpinene, αterpinene.…”

“…He suggested that the water extract of marjoram had a therapeutic and chelating effect against cadmiuminduced nephrotoxicity [36] . Previous study indicated that marjoram essential oils had a considerable free radical scavenging activity, thus protecting the organs of the body from injury associated with dietary obesity [37] . The synthetic compounds or drugs are often tried to overcome the infertility problems.…”

“…Furthermore, they demonstrated that marjoram is a rich source of terpenoids, asthymol, carvacrol, 4-terpineol, γ-terpinene, αterpinene. These terpenoids are natural products belonging to the chemical group of terpenes that are the main active constituents of marjoram essential oil and have an obvious role in controlling biosynthesis of the testosterone hormone and hence normalizing the male fertility [37] .…”

“…This enhancement can be linked to marjoram's strong antioxidant activity and high capacity to scavenge ROS, which play an important role in reducing lipid peroxidation and inflammation, and hence tissue injury [40,41]. Improvement in the testicular tissue can be related to the active constituents of marjoram, mainly phenolic terpenoids [37] . In the herbal or dietary plants, there are numerous bioactive terpenoids that modulate the activity of peroxisome proliferator-activated receptors (PPARs), which are ligand-dependent transcription factors belonging to the nuclear receptors [40] .…”