2001
DOI: 10.4269/ajtmh.2001.65.810
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Preventing opportunistic infections among human immunodeficiency virus-infected adults in African countries.

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Cited by 30 publications
(21 citation statements)
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“…In contrast, the ability of PPE-C (and its peptides) to distinguish between latent TB and incipient, subclinical TB would be of value in countries of TB endemicity where TB control is focused on detection and treatment only of patients with active TB. Preventive therapy with isoniazid has been shown to be beneficial in reducing the incidence of TB in both HIV Ϫ and HIV ϩ individuals and is especially recommended for HIV ϩ individuals (13,18). However, monotherapy in individuals with active TB runs the risk of fostering drug resistance (30), and no reliable tests that can differentiate between a truly latent infection and incipient, subclinical TB are available.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, the ability of PPE-C (and its peptides) to distinguish between latent TB and incipient, subclinical TB would be of value in countries of TB endemicity where TB control is focused on detection and treatment only of patients with active TB. Preventive therapy with isoniazid has been shown to be beneficial in reducing the incidence of TB in both HIV Ϫ and HIV ϩ individuals and is especially recommended for HIV ϩ individuals (13,18). However, monotherapy in individuals with active TB runs the risk of fostering drug resistance (30), and no reliable tests that can differentiate between a truly latent infection and incipient, subclinical TB are available.…”
Section: Discussionmentioning
confidence: 99%
“…In Uganda, the overall prevalence rate of HIV/AIDS is 7.0%, with an estimated 530,000 people infected (http://www.cdc.gov/nchstp/od/gap/countries/docs/ 04profiles/FY04%20OGAC%20Uganda.Final.pdf). Opportunistic infections (OI) present severe challenges to people living with HIV in Africa, where access to antiretroviral therapy is limited, palliative care is often suboptimal, and poor environmental conditions increase the risk of infection (Chaisson, 1998;Grant, 2001;Jeffrey, 1994). There is an urgent need for implementation of standardized, evidence-based measures to prevent OIs in adults and children with HIV .…”
Section: Introductionmentioning
confidence: 99%
“…Earlier studies with multiple serial serum samples from the same patients had shown that antibodies to the M. tuberculosis CFP preparation and to the semipurified native 81 (88)-kDa protein were detectable in serum samples obtained over several months during the time period prior to Seventy-five to 80% of the millions of HIV-infected individuals in sub-Saharan Africa and Southeast Asia are coinfected with M. tuberculosis, and TB is the leading cause of mortality and morbidity in these countries (2,3,8,21). Monotherapy with isoniazid is recommended by the Joint United Nations Programme on HIV/AIDS-World Health Organization to reduce the risk of TB in coinfected individuals, but administration of preventive monotherapy requires that active TB be excluded to reduce the risk of development of drug resistance (5,9,13). No reliable tests that can identify HIV ϩ individuals with incipient, subclinical TB are available, and exclusion is based on physical examination, patient history, and occasionally chest X-rays (5,13).…”
mentioning
confidence: 99%
“…Monotherapy with isoniazid is recommended by the Joint United Nations Programme on HIV/AIDS-World Health Organization to reduce the risk of TB in coinfected individuals, but administration of preventive monotherapy requires that active TB be excluded to reduce the risk of development of drug resistance (5,9,13). No reliable tests that can identify HIV ϩ individuals with incipient, subclinical TB are available, and exclusion is based on physical examination, patient history, and occasionally chest X-rays (5,13). Multidrug preventive therapy of all HIV ϩ individuals is not feasible, especially since repeated courses of preventive therapy or lifelong prophylaxis may be required (5,13 (1,6,8).…”
mentioning
confidence: 99%