Abstract-Maternal depression is recognized as a significant mental health problem in postpartum circumstances, particularly, prevalence may be considerably higher among low-income. The purpose of study was to identify average maternal postpartum depression and its predicting factors among low-income family during the first three months after delivery in Indonesia mothers. A cross sectional study was carried out, of 206 mothers in the first three months postpartum with family income monthly less than 3000000 IDR (US$230) who visited maternal and child health clinic in both Public Health Center, South Tangerang District, Banten Province and South Jakarta District, Jakarta Province, Indonesia. The participants were recruited by purposive sampling. Data collection was conducted during December 2015 to May 2016 by visiting home. Structured questionnaires for data collection included general information, Edinburgh Postnatal Depression Scale (EPDS), the Dyad Adjustment Scale (DAS), the Life Events Questionnaire (LEQ), Childcare Stress Inventory (CSI), and the Postpartum Support Questionnaire (PSQ). Descriptive statistics and standard multiple regression were employed for data analysis. Sixty-nine (33.5%) mothers experienced postpartum depression. Childcare stress, marital satisfaction and stressful life events could explain 51.1% of the variance in postpartum depression among low-income family (R² = 0.511, F = 41.766, p-value < 0.001). Significant predictors were childcare stress (ß= 0.408, P-value < 0.001), followed by stressful life events (ß = 0.310, p-value < 0.001), and marital satisfaction (ß = -0.155, p-value < 0.05). Low income family mothers with higher childcare stress, less satisfied with the marital relationship, and perceived the higher level of stressful life events may be important targets for maternal postpartum depression prevention in postpartum period.