Preventing preterm preeclampsia

Li, Yang Yang; Gu, Qian; Chen, Guo Rong; Quinn, MJ

doi:10.1016/j.ajog.2018.08.027

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…58,60,108 The FMF triple test has been endorsed by the International Federation of Gynecology and Obstetrics (FIGO). 42 The models developed by the United States and the Spanish researchers have failed or not undergone external validation, a process that is considered essential before clinical implementation. The timeline of the development of preeclampsia prediction models is illustrated in Figure 5.…”

Section: Expert Review Ajogorgmentioning

confidence: 99%

First trimester preeclampsia screening and prediction

Chaemsaithong

Sahota

Poon

2022

American Journal of Obstetrics and Gynecology

204

153

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P reeclampsia is a multisystem disorder of pregnancy characterized by new onset of hypertension with significant proteinuria after 20 weeks' gestation. 1e7 This disorder affects 2% to 8% of pregnant women and is one of the leading causes of maternal and perinatal morbidity and mortality. Worldwide, 76,000 women and 500,000 babies die yearly from this disorder. 4,8,9 Preeclampsia causes immediate maternal adverse effects, including impairment of hepatorenal and coagulation systems. 10 If left untreated or in severe form, maternal pulmonary edema, eclampsia, brain injury, and death can occur. 11e13 Inadequate uteroplacental perfusion leads to fetal growth restriction and/or placental abruption, resulting in indicated preterm birth or stillbirth. Moreover, preeclampsia is associated with an increased risk of long-term cardiovascular and chronic diseases in both the mothers and their children from the affected pregnancy. 14 Specifically, women with preeclampsia are at elevated risk for chronic hypertension, future cardiovascular disease, stroke, metabolic syndromes, cognitive impairment, and chronic end-stage renal disease later in life. 15e22 Infants born to mothers affected by preeclampsia are also at risk of having medium-and long-term

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Section: Expert Review Ajogorgmentioning

confidence: 99%

First trimester preeclampsia screening and prediction

Chaemsaithong

Sahota

Poon

2022

American Journal of Obstetrics and Gynecology

204

153

View full text Add to dashboard Cite

show abstract

“…MAP was measured in duplicates using a validated automated electronic BP device according to the standard guideline. 16 Most of the low-dose aspirin (Bokey) of 100 mg was administered daily before week 16 in those screened positive until delivery. Mothers who experienced abortion or stillbirth due to congenital anomalies and those who did not show signs of preeclampsia at the same time were excluded.…”

Section: Methodsmentioning

confidence: 99%

Effect of Low-Dose Aspirin in Preventing Early-Onset Preeclampsia in the Taiwanese Population—A Retrospective Cohort Study

Law¹,

Wei²

2021

IJWH

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Hemodynamic consequences of incomplete uterine spiral artery transformation in human pregnancy, with implications for placental dysfunction and preeclampsia

Zamir

Nelson

Ginosar

2021

Journal of Applied Physiology

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Normal human pregnancy requires a dramatic increase in uteroplacental blood flow which is achieved by a transformation in the geometry of uterine spiral arteries, a key element in this blood supply system. The transformation is mediated by trophoblast invasion directed at converting a portion of the spiral artery into an open funnel, thereby greatly reducing resistance to flow. The converted portion lies within the depth of the decidua and part of the myometrium. Insufficient depth of trophoblast invasion in early pregnancy predisposes to inadequate perfusion of the developing placenta andfetus and may lead to preeclampsia, fetal growth restriction and preterm delivery, sometimes referred to as the "Great Obstetrical Syndromes". We examine the hemodynamic consequences of spiral artery transformation in human pregnancy and the relationship between the degree of transformation and the corresponding change in flow rate and resistance to flow. We identify two key variables in determining the hemodynamic change: the longitudinal converted fraction of the spiral artery and the relative downstream diameterof the open funnel. Our results indicate that there is a critical threshold in the value of the converted fraction required to achieve the marked increase in uteroplacental blood flow in normal pregnancy. This finding validates common clinical observations that the depth of trophoblast invasion reflects the "adequacy" of the increase in uteroplacental blood supply required in normal human pregnancy. Our results provide a quantitative measure of that adequacy and may serve as a future diagnostic marker for high-risk pregnancy.

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Preventing preterm preeclampsia

Cited by 3 publications

References 4 publications

First trimester preeclampsia screening and prediction

First trimester preeclampsia screening and prediction

Effect of Low-Dose Aspirin in Preventing Early-Onset Preeclampsia in the Taiwanese Population—A Retrospective Cohort Study

Hemodynamic consequences of incomplete uterine spiral artery transformation in human pregnancy, with implications for placental dysfunction and preeclampsia

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