2023
DOI: 10.3390/jcm12185938
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Preventing Rejection of the Kidney Transplant

Divyanshu Malhotra,
Priyanka Jethwani

Abstract: With increasing knowledge of immunologic factors and with the advent of potent immunosuppressive agents, the last several decades have seen significantly improved kidney allograft survival. However, despite overall improved short to medium-term allograft survival, long-term allograft outcomes remain unsatisfactory. A large body of literature implicates acute and chronic rejection as independent risk factors for graft loss. In this article, we review measures taken at various stages in the kidney transplant pro… Show more

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Cited by 8 publications
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“…Compared with calcineurin inhibitors, belatacept showed no difference in preventing acute rejection episodes, graft loss or death. However, it offered some advantages: better kidney function after transplant, less chronic kidney scarring, decreased rate of donor-specific antibodies development, improved blood pressure values, better lipid blood levels and lower incidence of diabetes onset [ 72 , 73 , 74 ].…”
Section: Immunologic Strategies In Vcamentioning
confidence: 99%
“…Compared with calcineurin inhibitors, belatacept showed no difference in preventing acute rejection episodes, graft loss or death. However, it offered some advantages: better kidney function after transplant, less chronic kidney scarring, decreased rate of donor-specific antibodies development, improved blood pressure values, better lipid blood levels and lower incidence of diabetes onset [ 72 , 73 , 74 ].…”
Section: Immunologic Strategies In Vcamentioning
confidence: 99%