Preventing Surgically Induced Diabetes After Total Pancreatectomy via Autologous Islet Cell Reimplantation

Abstract

Total pancreatectomy may be the only treatment option that relieves pain and tissue destruction for patients with chronic pancreatitis, but this procedure causes surgically induced diabetes, which is difficult to manage because of the absence of insulin-producing beta cells. Some patients may benefit from autologous islet cell reimplantation, a procedure that involves collecting and purifying the islets of Langerhans from the patient's own resected pancreas and reinfusing them into the patient via the portal vein. Typically, candidates for this procedure are younger adults with nondilated pancreatitis that has yet to develop into glucose intolerance. Islet cell transplantation success varies and is directly related to the quality and quantity of the patient's pancreas and the damage caused by the chronic pancreatitis.

Autologous islet cell transplantation to prevent surgical diabetes

“…An excellent practical manual for managing patients during AIT has been published 67 . This manual will also be helpful in promoting AIT to patients who need this treatment.…”

Evaluation of the Key Mechanism Justifying the High Sensitivity of Obese Rodents to Treptozotocin (STZ)

“…A large number of species have been used in diabetes studies, including primates [1] [2] Rodents have the highest recorded use, especially for studies engaged in testing natural compounds and pharmaceuticals; this is due to their small size, ease of availability, short generation interval and economic considerations [3]. Diabetic animal models have been developed by a number of methods ranging from genetic [4] [5] chemical [6], spontaneous autoimmune [7], viral [8] [9], surgical (pancreatectomy) [9] to diet-associated [3] [10] [11]. The induction method to be considered depends on the type of DM to be developed and the objectives of the research [6].…”