Preventing the thermal degradation of astaxanthin through nanoencapsulation

Tachaprutinun, Amornset; Udomsup, Thanchanok; Luadthong, Chuleeporn; Wanichwecharungruang, Supason

doi:10.1016/j.ijpharm.2009.03.001

Cited by 124 publications

(73 citation statements)

References 28 publications

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“…An important question that is widely discussed is the influence of complex formation on carotenoid reactivity and stability (Yuan et al, 2013;Polyakov et al, 2010;2013;Apanasenko et al, 2015;Tachaprutinun et al, 2009). The reactivity of carotenoids towards metal ions, quinones and free radicals is closely related to their antioxidant activity as well as their stability in living systems, food and medical preparations.…”

Section: Interaction Of Carotenoids and Their Ga Complexes With Fe Iomentioning

confidence: 99%

“…Fundamental and applied research has recently been devoted to the inclusion complexes of carotenoids with natural oligosaccharides and polysaccharides, which are assumed to possess protective properties and to decrease the hydrophobic behavior of the included molecules (Polyakov, Leshina, Konovalova, Hand, & Kispert, 2004a;Polyakov, Leshina, Salakhutdinov, & Kispert, 2006a;Polyakov, Leshina, Salakhutdinov, Konovalova, & Kispert, 2006b;Polyakov et al, , 2010Polyakov, Magyar, & Kispert, 2013;Apanasenko et al, 2015;Gomes et al, 2014;Pinho, Grootveld, Soares, & Henriques, 2014;Gharibzahedi, Razavi, & Mousavi, 2014;Jose et al, 2014;Yuan, Du, Jin, & Xu, 2013;Yuan, Jin, & Xu, 2012;De Oliveira et al, 2011;Stancanelli et al, 2012;Tachaprutinun, Udomsup, Luadthong, & Wanichwecharungruang, 2009). For example, astaxanthin encapsulated into poly(ethylene oxide)-4-methoxycinnamoylphthaloyl chitosan showed minimal heat degradation after a twohour heating at 70 • C in an aqueous environment, in contrast to that of unencapsulated carotenoid molecules which were almost completely destroyed (Tachaprutinun et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…For example, astaxanthin encapsulated into poly(ethylene oxide)-4-methoxycinnamoylphthaloyl chitosan showed minimal heat degradation after a twohour heating at 70 • C in an aqueous environment, in contrast to that of unencapsulated carotenoid molecules which were almost completely destroyed (Tachaprutinun et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Water soluble biocompatible vesicles based on polysaccharides and oligosaccharides inclusion complexes for carotenoid delivery

Polyakov

Kispert

2015

Carbohydrate Polymers

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Since carotenoids are highly hydrophobic, air- and light-sensitive hydrocarbon compounds, developing methods for increasing their bioavailability and stability towards irradiation and reactive oxygen species is an important goal. Application of inclusion complexes of "host-guest" type with polysaccharides and oligosaccharides such as arabinogalactan, cyclodextrins and glycyrrhizin minimizes the disadvantages of carotenoids when these compounds are used in food processing (colors and antioxidant capacity) as well as for production of therapeutic formulations. Cyclodextrin complexes which have been used demonstrated enhanced storage stability but suffered from poor solubility. Polysaccharide and oligosaccharide based inclusion complexes play an important role in pharmacology by providing increased solubility and stability of lipophilic drugs. In addition they are used as drug delivery systems to increase absorption rate and bioavailability of the drugs. In this review we summarize the existing data on preparation methods, analysis, and chemical reactivity of carotenoids in inclusion complexes with cyclodextrin, arabinogalactan and glycyrrhizin. It was demonstrated that incorporation of carotenoids into the "host" macromolecule results in significant changes in their physical and chemical properties. In particular, polysaccharide complexes show enhanced photostability of carotenoids in water solutions. A significant decrease in the reactivity towards metal ions and reactive oxygen species in solution was also detected.

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Section: Interaction Of Carotenoids and Their Ga Complexes With Fe Iomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Water soluble biocompatible vesicles based on polysaccharides and oligosaccharides inclusion complexes for carotenoid delivery

Polyakov

Kispert

2015

Carbohydrate Polymers

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“…Based on the limited water solubility of astaxanthin, different esters, such as disodium disuccinate, tetrasodium diphosphate, divitamin C disuccinate and fatty acid astaxanthin have been prepared in attempts to improve astaxanthin solubility and stability (Tachaprutinun et al, 2009). Studies have suggested that incorporation of astaxanthin with compounds, such as β-cyclodextrin, hydroxypropyl-β-cyclodextrin, and chitosan, can provide protection against temperature and improve the stability of astaxanthin (Miao et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Encapsulation in compounds such as poly(ethyleneoxide)-4-methoxycinnamoylphthaloylchitosan (PCPLC), or chitosan was reported as another effective strategy to solve the solubility and stability issue with astaxanthin (Tachaprutinun et al, 2009). Moreover, storage of dry algal meal under vacuum conditions was able to retain 90% of the initial astaxanthin content (Gouveia and Empis, 2003).…”

Section: Introductionmentioning

confidence: 99%

Induction of carotenoid and phytosterol accumulation in microalgae

Ahmed¹

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Microalgae have become well-known in the last few decades as producers of various compounds of high nutritional value, such as long chain polyunsaturated fatty acids, pigments including carotenoids, proteins, sterols, and vitamins. Among these compounds, carotenoids and phytosterols have been receiving increased attention based on the discoveries that they are capable of preventing various diseases such as cardiovascular problems, certain cancers, and neurological disorders, e.g. Alzheimer's, amyotrophic lateral sclerosis etc. The commercial exploitation of the microalgal strains Dunaliella salina and Haematococcus pluvialis for β-carotene and astaxanthin, respectively, led to the hypothesis for the current study that other microalgal strains may even have a higher potential to produce these compounds, especially when the underlying physiological pathways that lead to elevated levels of these compounds could be stimulated. The aims of this thesis were therefore (1) to screen microalgal strains for their potential to produce carotenoids and phytosterols and (2) to induce the top producer(s) to accumulate higher quantities of carotenoids and phytosterols and (3) to scale up the successful induction method(s) to explore large-scale commercial production of these metabolites. Moreover, the well-known sensitive nature of carotenoids (e.g. astaxanthin and β-carotene) to light, drying and preservation methods led to the idea that freeze-drying rather than the currently popular spray-drying methods could be more suitable for long-term storage of highly valuable carotenoids, such as astaxanthin.As a first step, screening was carried out on twelve microalgal strains collected from brackish and marine waters for carotenoid profiles and contents, antioxidant capacity (total phenolic content and oxygen radical absorbance capacity (ORAC), and phytosterol profiles and

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