2021
DOI: 10.1177/03008916211025609
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Prevention and management of acute esophageal toxicity during concomitant chemoradiotherapy for locally advanced lung cancer

Abstract: Background: Standard treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is concomitant chemoradiotherapy. The survival benefit of combined treatment is partially counterbalanced by an increased rate of acute esophageal toxicity. Several pharmaceutical products are available for prevention and management of esophagitis, including Faringel Plus. Aim: To assess the incidence and the grade, identify the correlations with clinical, dosimetric, and therapeutic variables, and analyse the role of Far… Show more

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“…These data could probably suggest that, with accurate clinical support (prevention and management of toxicities or pulmonary rehabilitation) and the use of modern radiotherapy techniques, even fragile patients could aspire to treatment with curative intent (28)(29)(30)(31).…”
Section: Discussionmentioning
confidence: 99%
“…These data could probably suggest that, with accurate clinical support (prevention and management of toxicities or pulmonary rehabilitation) and the use of modern radiotherapy techniques, even fragile patients could aspire to treatment with curative intent (28)(29)(30)(31).…”
Section: Discussionmentioning
confidence: 99%
“…Data from meta-analysis show that severe esophagitis is the only side effect with a significantly higher rate in CCRT as compared to sequential chemo-radiotherapy (SCRT) [ 6 ], despite improvements in radiotherapy techniques and supportive care have reduced the occurrence of this complication [ 7 ]. However, in the clinical practice, CCRT is often considered less tolerated, and other side effects, such as respiratory disorders, can potentially negatively affect the patient's quality of life (QoL) and general health [ 8 ].…”
Section: Introductionmentioning
confidence: 99%