Prevention and management of acute kidney injury in the perioperative patient

Drury, Natalie; Lewington, Andrew

doi:10.1016/j.mpsur.2018.09.016

Cited by 2 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(5) Di Indonesia, perawatan penyakit ginjal merupakan ranking kedua pembiayaan terbesar dari BPJS kesehatan setelah penyakit jantung. (6) Drug Induced Acute kidney Injury (D-AKI) adalah tipe gangguan fungsi ginjal akut yang disebabkan oleh obat. Menurut klasifikasi KDIGO, terdapat 50,2% kasus.…”

Section: Pendahuluanunclassified

Pemakaian Obat Nefrotoksik Sebagai Determinan Drug-Induced Acute Kidney Injury (D-AKI)

Hadiwati,

Andrajati,

Syafhan

et al. 2024

JPKSF

View full text Add to dashboard Cite

Events related to drug reactions are very difficult to recognize, because they often look like other diseases and many symptoms of drug reactions appear, especially for short drug exposures. Acute Kidney Injury is a condition that affects the structure and function of the kidneys, which is characterized by a sudden decrease in kidney function which causes necrosis of the tubules. The aim of this study was to analyze the prevalence of Drug-Induced Acute Kidney Injury and determine the main risk factors as well as drug data that can influence the increase in serum creatinine levels during treatment. This study implemented a cross-sectional design. The sampling location was the Medical Records section of Gatot Soebroto Army Hospital, with a sample size of 56 patients identified using the Kidney Disease Improving Global Outcomes (KDIGO) criteria and using trigger tools. Data were analyzed using the Chi-square test. The results of the analysis showed that the prevalence of Drug-Induced Acute Kidney Injury in the RSPAD Gatot Soebroto inpatient room was 8.975%-18.527%. Factors that influence the occurrence of Drug-Induced Acute Kidney Injury in the inpatient room were comorbidities (PR = 8.975; 95% CI = 1.317-61.159; p-value = 0.025) and drug interactions (PR = 18.527; 95% CI = 1.727 -177.909; p-value = 0.011). In general, the most widely used nephrotoxic drugs were a combination of >3 types of nephrotoxic drugs, diuretics, NSAIDs, cephalosporins, ARBs, ACEi and chemotherapy drugs. Based on the research results, it was concluded that the use of nephrotoxic drugs was a determinant of Drug-Induced Acute Kidney Injury in the Gatot Soebroto Army Hospital inpatient room.Keywords: kidney disease; Drug-Induced Acute Kidney Injury; nephrotoxic drugs; trigger tools; creatinine ABSTRAK Kejadian yang berhubungan dengan reaksi obat sangat sulit dikenali, karena sering tampak seperti penyakit lain dan banyak gejala reaksi obat yang muncul, terutama untuk paparan obat yang singkat. Acute Kidney Injury adalah salah satu dari kondisi yang mempengaruhi struktur dan fungsi ginjal, yang ditandai dengan penurunan fungsi ginjal secara tiba-tiba yang menyebabkan nekrosis pada tubulus. Tujuan penelitian ini adalah menganalisis prevalensi Drug-Induced Acute Kidney Injury dan menentukan faktor risiko utama serta data obat-obatan yang dapat mempengaruhi peningkatan kadar kreatinin serum selama dirawat. Penelitian ini menerapkan desain cross-sectional. Tempat pengambilan sampel adalah bagian Rekam Medis RSPAD Gatot Soebroto, dengan ukuran sampel adalah 56 pasien yang diidentifikasi dengan menggunakan kriteria Kidney Disease Improving Global Outcomes (KDIGO) dan menggunakan trigger tools. Data dianalisis menggunakan uji Chi-square. Hasil analisis menunjukkan bahwa prevalensi Drug-Induced Acute Kidney Injury di ruang rawat inap RSPAD Gatot Soebroto adalah 8,975%-18,527%. Faktor-faktor yang mempengaruhi terjadinya Drug-Induced Acute Kidney Injury di ruang rawat inap adalah komorbid (PR = 8,975; 95% CI = 1,317-61,159; p-value = 0,025) dan interaksi obat (PR = 18,527; 95% CI = 1,727-177,909; p-value = 0,011). Secara umum obat nefrotoksik yang paling banyak digunakan adalah kombinasi obat nefrotoksik >3 macam, obat diuretik, NSAID, sefalosporin, ARB, ACEi dan obat kemoterapi. Berdasarkan hasil penelitian disimpulkan bahwa pemakaian obat nefrotoksik merupakan determinan dari Drug-Induced Acute Kidney Injury di ruang rawat inap RSPAD Gatot Soebroto.Kata kunci: kidney disease; Drug-Induced Acute Kidney Injury; obat nefrotoksik; trigger tool; kreatinin

show abstract

Section: Pendahuluanunclassified

Pemakaian Obat Nefrotoksik Sebagai Determinan Drug-Induced Acute Kidney Injury (D-AKI)

Hadiwati,

Andrajati,

Syafhan

et al. 2024

JPKSF

View full text Add to dashboard Cite

show abstract

“…Perioperative acute kidney injury is related to inadequate fluid replacement and increases morbidity and mortality of surgical patients. 2 , 8 , 9 , 10 Thus, early diagnosis and immediate treatment are essential. 9 , 10 Normally, plasma creatinine and urine output are used to diagnose AKI according KDIGO guidelines, 10 although the first may take 48 hours to rise, and the latter can be affected by endocrine-metabolic response to surgery 10 The advent of new renal biomarkers, such as NGAL (neutrophil gelatinase-associated lipocalin), and KIM-1 (kidney injury molecule-1), has enabled early diagnosis of kidney injury.…”

Section: Introductionmentioning

confidence: 99%

“… 2 , 8 , 9 , 10 Thus, early diagnosis and immediate treatment are essential. 9 , 10 Normally, plasma creatinine and urine output are used to diagnose AKI according KDIGO guidelines, 10 although the first may take 48 hours to rise, and the latter can be affected by endocrine-metabolic response to surgery 10 The advent of new renal biomarkers, such as NGAL (neutrophil gelatinase-associated lipocalin), and KIM-1 (kidney injury molecule-1), has enabled early diagnosis of kidney injury. 10 , 11 , 12 NGAL is absent in the urine and plasma of healthy individuals and is expressed as early as 2 hours after renal ischemia.…”

Section: Introductionmentioning

confidence: 99%