Prevention and Management of Infectious Complications in Kidney Transplant Recipients

Santos, Rowena Delos; Brennan, Daniel C.

doi:10.1007/978-1-4939-0342-9_27

Cited by 2 publications

(1 citation statement)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is thought to be a risk marker for developing a urinary tract infection (UTI) which, if not controlled in time, represents an adverse event for these patients ( 1 ). Several factors contribute to increased susceptibility to UTI in KTR, including the patient's genetic and immunological background, the anatomy of the native kidneys, the origin of the donor organ and surgical complications during transplantation ( 2 , 3 ). Although the “net state of immunosuppression” has been postulated as a conceptual framework linking immunosuppression and risk of infection, studies measuring the actual impact of immunosuppression as a cause of increased UTI, and immune system involvement in the infectious process, are incomplete ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Monocyte-derived dendritic cells can be detected in urine of kidney transplant recipients with pathogenic asymptomatic bacteriuria

Salvadé,

Manuel,

Golshayan

et al. 2024

Front. Transplant.

View full text Add to dashboard Cite

Urinary tract infections (UTI) are an important clinical problem in kidney transplant recipients (KTR). Asymptomatic bacteriuria (ASB) is frequent in these patients and often resolved by the immune system, but a significant proportion may progress to complicated UTI, which may compromise allograft function and survival. It is essential to determine the involvement of the immune system in the infectious process. Dendritic cells (DCs) are recognised as playing a pivotal role in initiating inflammatory responses capable of priming antigen-specific T cells, a crucial step in determining the fate of local inflammation. Little is known about their role in the control of UTI. In this brief communication, we report an incidental finding in a group of 16 stable KTR in which monocyte-derived dendritic cells (ModDCs), analysed by flow cytometry, were found in urine of patients with ASB and high bacterial counts >107 cfu/ml. Within this group, one patient developed pyelonephritis in the following days. These findings suggest that the immune system, in particular DCs, may be recruited during the course of a UTI and, to our knowledge, present for the first time evidence that inflammatory ModDCs can be detected in urine. Their frequency may reflect the degree of infection. This finding suggests the potential for exploring whether these cells may be useful in distinguishing between pathogenic ASB and those that can be resolved by the immune system.

show abstract