Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia

Radvansky, Lauren J.; Pace, Makala B.; Siddiqui, Asif

doi:10.2146/ajhp120467

Cited by 76 publications

(55 citation statements)

References 37 publications

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“…According to the authors, serous acini are the first to undergo alterations resulting from radiotherapy, followed by mucous membranes and duct cells. There is a consensus that changes in the salivary flow will happen when salivary glands receive more than 50 Gy of radiation, and below that, they can be transitory and limited [7]. Xerostomia is commonly reported by patients after the first week of RT, and an increase in its severity is observed along the weeks of RT [8].…”

Section: Introductionmentioning

confidence: 99%

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Palmieri

Ornaghi

Martins

et al. 2018

Journal of Oral Microbiology

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Background: Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective: The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods: In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy. The samples were submitted to PCR and enzymatic digestion for detection of human herpesviruses. Xerostomia was evaluated according to the Seminars in Radiation Oncology criteria. Results: There was a higher frequency of grade 1 xerostomia (51.4%), observed first in the 1st week of radiotherapy. In the 4th week of radiotherapy, all patients presented some degree of xerostomia. Analysis of herpesviruses showed oral shedding of EBV, HHV-6 and HHV-7 in all weeks. Considering all the periods, the highest frequency was in patients with EBV excretion (55.0%), which was significantly higher than that of other viruses. Conclusion: We observed that oral shedding of herpesviruses was not affected by xerostomia as there was a progression in their excretion, even with the evolution of xerostomia. This suggested that there is a local replication in the oral cavity that is not completely dependent of salivary excretion.

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Section: Introductionmentioning

confidence: 99%

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Palmieri

Ornaghi

Martins

et al. 2018

Journal of Oral Microbiology

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“…9 In the early stages, the skin changes can include oedema, erythema, dry desquamation and moist desquamation, while in the late stages the adverse effects mostly include pigmentation changes, telangiectasias, hair loss, atrophy, fibrosis and ulceration. [3][4][5][6][7][8][9][10] Severe acute dermatitis invariably needs cessation of the planned radiation therapy, as this can aggravate the skin damage and increase chances of topical and systemic infection, all of which can increase the morbidity and complicate the clinical condition of a patient. [3][4][5][6][7][8][9][10] Mechanistically, the ionizing radiation-induced skin damage can be attributed to either a direct effect or an indirect effect resulting from the hydrolysis of water and inflammation-induced secondary injury.…”

Section: Resultsmentioning

confidence: 99%

Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: a pilot study

Palatty¹,

Azmidah²,

Rao³

et al. 2014

BJR

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“…Međutim, starenje nije glavni uzrok kserostomije. Ona je najčešće povezana sa sistemskim oboljenjima, uzimanjem lijekova i radioterapijom glave i vrata [33,34]. Pored toga, pušenje duvana, kao i unos alkohola znatno smanjuju salivaciju, te doprinose pojavi kserostomije [35].…”

Section: Kserostomijaunclassified

Bolesti usta i zuba kod starih

Ivković

Davidović

Račić

et al. 2016

BII

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Bolesti usta i zuba kod starihNedeljka Ivković¹, Brankica Davidović¹, Maja Račić¹, Đorđe Božović¹, Dijana Popović-Grubač¹, Marko Milosavljević² ¹Medicinski fakultet u Foči, Univerzitet u Istočnom Sarajevu, Republika Srpska, Bosna i Hercegovina ²Fakultet medicinskih nauka Kragujevac, Univerzitet u Kragujevcu, Srbija Kratak sadržajStarenje je prirodan i ireverzibilan fiziološki proces koji zavisi od faktora nasljeđa, faktora sredine, ali i od načina života. Pri tome bitnu ulogu imaju brojni fiziološki, biološki, psihološki i drugi faktori. U odnosu na starost i starenje postoje veoma izražene individualne razlike. Starost čitavog organizma čovjeka, kao i pojedinih organa i sistema, ne počinje kod svih osoba u isto vrijeme, niti se razvija istom brzinom. Taj proces doprinosi pogoršanju zdravlja i konačno vodi smrti, ali pri tome nije značajna samo dužina, već i kvalitet života.Starenje, skoro bez izuzetka, dovodi do manjeg ili većeg smanjenja kvaliteta života. Na kvalitet života može veoma značajno da utiče i stanje usta i zuba, oboljenja ili nedostatak većine ili svih zuba. Najčešća oralna oboljenja i stanja koja utiču na kvalitet života, i koja mijenjaju brojne funkcije orofacijalnog sistema su: gubitak zuba, parodontopatije, karijes, prekancerozne lezije usne duplje i karcinomi, kserostomija i resorpcija kosti alveolarnog grebena.Da bi se doprinijelo rješavanju problema starih osoba, potrebno je da se stomatolozi više bave starim osobama, da se organizuju redovni stomatološki kontrolni pregledi, da se tom prilikom pregledaju sva tkiva usne duplje i okoline, a ne samo zubi, da se poboljša oralna higijena i da se obezbijedi efikasna kućna stomatološka njega, posebno nepokretnih starih osoba. Posebno je važno brigu o oralnom zdravlju uključiti u nacionalne programe očuvanja opšteg zdravlja, jer je to najefikasniji put za poboljšanje oralnog zdravlja i kvaliteta života starih osoba. Ključne riječi: gerontostomatologija, starenje, oralno zdravljeAdresa autora: Prof. dr Nedeljka Ivković, Svetosavska bb, 73300 Foča, neda.ivkovic3@gmail.com Starost i starenjeStarenje, proces koji započinje začećem individue i traje do njene smrti, predstavlja univerzalan, neizbježan fenomen progresivnog toka, rezultat interakcije genetskih faktora, faktora okoline i načina života. Pored toga, starenje kao dinamičan proces uslovljen je biološkim, fiziološkim, psihološkim i socijalnim faktorima [1][2][3]. Starost je stanje nastalo kao rezultat procesa starenja i počin-je nakon perioda zrelosti, kada se uočava progresivno opadanje funkcionalne sposobnosti, te porast osjetljivosti na bolesti. U

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Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia

Cited by 76 publications

References 37 publications

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: a pilot study

Bolesti usta i zuba kod starih

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